Detalhe da pesquisa
1.
The Comparison of Machine Learning and Mechanistic In Vitro-In Vivo Extrapolation Models for the Prediction of Human Intrinsic Clearance.
Mol Pharm;
20(11): 5616-5630, 2023 11 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37812508
2.
Prediction of Fraction Unbound in Microsomal and Hepatocyte Incubations: A Comparison of Methods across Industry Datasets.
Mol Pharm;
16(9): 4077-4085, 2019 09 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31348668
3.
In-Silico Extraction of Design Ideas Using MMPA-by-QSAR and its Application on ADME Endpoints.
J Chem Inf Model;
59(1): 477-485, 2019 01 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30497262
4.
A multi-endpoint matched molecular pair (MMP) analysis of 6-membered heterocycles.
Bioorg Med Chem;
25(1): 381-388, 2017 01 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27840138
5.
Reversion of somatic mutations of the respiratory syncytial virus-specific human monoclonal antibody Fab19 reveal a direct relationship between association rate and neutralizing potency.
J Immunol;
190(7): 3732-9, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23455501
6.
Correction to "Prediction of Fraction Unbound in Microsomal and Hepatocyte Incubations: A Comparison of Methods across Industry Datasets".
Mol Pharm;
16(11): 4755, 2019 Nov 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31596590
7.
Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors.
Nature;
455(7212): 532-6, 2008 Sep 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18716625
8.
Characterization and Applications of Permeabilized Hepatocytes in Drug Discovery.
AAPS J;
26(3): 38, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38548986
9.
Interpretable, probability-based confidence metric for continuous quantitative structure-activity relationship models.
J Chem Inf Model;
53(2): 368-83, 2013 Feb 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23343412
10.
In Vitro-In Vivo Extrapolation and Scaling Factors for Clearance of Human and Preclinical Species with Liver Microsomes and Hepatocytes.
AAPS J;
25(3): 40, 2023 04 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37052732
11.
Use of high throughput ion channel profiling and statistical modeling to predict off-target arrhythmia risk - One pharma's experience and perspective.
J Pharmacol Toxicol Methods;
118: 107213, 2022.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36084863
12.
Early Drug-Induced Liver Injury Risk Screening: "Free," as Good as It Gets.
Toxicol Sci;
188(2): 208-218, 2022 07 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35639956
13.
Extraction of tacit knowledge from large ADME data sets via pairwise analysis.
Bioorg Med Chem;
19(12): 3739-49, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21616672
14.
The Impact of a Breastfeeding Promotion Intervention on Rapid Weight Gain among African American Infants.
J Health Care Poor Underserved;
32(1): 271-295, 2021.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33678697
15.
Evaluation of Prediction Accuracy for Volume of Distribution in Rat and Human Using In Vitro, In Vivo, PBPK and QSAR Methods.
J Pharm Sci;
110(4): 1799-1823, 2021 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33338491
16.
A Physiologically Based in Silico Tool to Assess the Risk of Drug-Related Crystalluria.
J Med Chem;
63(12): 6489-6498, 2020 06 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32130005
17.
Structural attributes influencing unbound tissue distribution.
Eur J Med Chem;
185: 111813, 2020 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31732255
18.
Evaluation of Fraction Unbound Across 7 Tissues of 5 Species.
J Pharm Sci;
109(2): 1178-1190, 2020 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31704191
19.
Mechanistic insights on clearance and inhibition discordance between liver microsomes and hepatocytes when clearance in liver microsomes is higher than in hepatocytes.
Eur J Pharm Sci;
155: 105541, 2020 Dec 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32927071
20.
The use of matched molecular series networks for cross target structure activity relationship translation and potency prediction.
Medchemcomm;
8(11): 2067-2078, 2017 Nov 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30108724