Detalhe da pesquisa
1.
Therapeutic reactivation of mutant p53 protein by quinazoline derivatives.
Invest New Drugs;
30(5): 2035-45, 2012 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21912889
2.
Comparative effects in rats of intact wheat bran and two wheat bran fractions on the disposition of the mutagen 2-amino-3-methylimidazo[4,5-f]quinoline.
Mutat Res;
716(1-2): 59-65, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21939672
3.
Enhancement of the action of the antivascular drug 5,6-dimethylxanthenone-4-acetic acid (DMXAA; ASA404) by non-steroidal anti-inflammatory drugs.
Invest New Drugs;
27(3): 280-4, 2009 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18696010
4.
Development and validation of a liquid chromatography-mass spectrometry (LC-MS) assay for the determination of the anti-cancer agent N-[2-(dimethylamino)ethyl]-2,6-dimethyl-1-oxo-1,2-dihydrobenzo[b]-1,6-naphthyridine-4-carboxamide (SN 28049).
J Chromatogr B Analyt Technol Biomed Life Sci;
875(2): 368-72, 2008 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18926778
5.
Improvement of the antitumor activity of intraperitoneally and orally administered 5,6-dimethylxanthenone-4-acetic acid by optimal scheduling.
Clin Cancer Res;
9(17): 6545-50, 2003 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14695159
6.
Thalidomide pharmacokinetics and metabolite formation in mice, rabbits, and multiple myeloma patients.
Clin Cancer Res;
10(17): 5949-56, 2004 Sep 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15355928
7.
Transport of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide by human intestinal Caco-2 cells.
Eur J Pharm Sci;
24(5): 513-24, 2005 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15784341
8.
Preclinical factors affecting the interindividual variability in the clearance of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid.
Biochem Pharmacol;
65(11): 1853-65, 2003 Jun 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12781337
9.
Preclinical factors influencing the relative contributions of Phase I and II enzymes to the metabolism of the experimental anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid.
Biochem Pharmacol;
65(1): 109-20, 2003 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12473385
10.
Induction of tumour necrosis factor and interferon-gamma in cultured murine splenocytes by the antivascular agent DMXAA and its metabolites.
Biochem Pharmacol;
67(5): 937-45, 2004 Mar 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15104247
11.
Oral activity and pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice.
Cancer Chemother Pharmacol;
49(1): 20-6, 2002 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11855749
12.
Gender differences in the metabolism and pharmacokinetics of the experimental anticancer agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA).
Cancer Chemother Pharmacol;
49(2): 126-32, 2002 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11862426
13.
Modulation of thalidomide pharmacokinetics by cyclophosphamide or 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice: the role of tumour necrosis factor.
Cancer Chemother Pharmacol;
53(5): 377-83, 2004 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15060740
14.
Potentiation of the antitumour effect of cyclophosphamide in mice by thalidomide.
Cancer Chemother Pharmacol;
50(3): 186-92, 2002 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12203100
15.
Thalidomide in cancer treatment: a potential role in the elderly?
Drugs Aging;
19(2): 85-100, 2002.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11950376
16.
Strain differences in the liver microsomal metabolism of the experimental anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid in mice.
J Chromatogr B Analyt Technol Biomed Life Sci;
776(2): 231-6, 2002 Sep 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12138005
17.
High-throughput screening of potential inhibitors for the metabolism of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid.
J Chromatogr B Analyt Technol Biomed Life Sci;
767(1): 19-26, 2002 Feb 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11863291
18.
Determination of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide in Caco-2 monolayers by liquid chromatography with fluorescence detection: application to transport studies.
J Chromatogr B Analyt Technol Biomed Life Sci;
809(1): 87-97, 2004 Sep 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15282097
19.
Contrasting effects of non-starch polysaccharide and resistant starch-based diets on the disposition and excretion of the food carcinogen, 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), in a rat model.
Food Chem Toxicol;
41(6): 785-92, 2003 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12738184
20.
Non-specific binding of the experimental anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in liver microsomes from various species.
J Pharm Pharmacol;
54(7): 997-1003, 2002 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12162720