Echocardiography-based hemodynamic management of left ventricular diastolic dysfunction: a feasibility and safety study.

BACKGROUND: Patients with left ventricular diastolic dysfunction (LVDD) are at increased risk of postoperative adverse events. The primary aim of this study was to evaluate the safety and feasibility of using echocardiography-guided hemodynamic management (EGHEM) during surgery in subjects with LVDD compared to conventional management. The feasibility of using echocardiography to direct a treatment algorithm and clinical outcomes were compared for safety between groups. METHODS: Subjects were screened for LVDD by preoperative transthoracic echocardiography (TTE) and randomized to the conventional or EGHEM group. Subjects in EGHEM received hemodynamic management based on left ventricular filling patterns on transesophageal echocardiography (TEE). Primary outcomes measured were the feasibility to obtain TEE images and follow a TEE-based treatment algorithm. Safety outcomes also compared the following clinical differences between groups: length of hospitalization, incidence of atrial fibrillation, congestive heart failure (CHF), myocardial infarction, cerebrovascular accident, transient ischemic attack and renal failure measured 30 days postoperatively. RESULTS: Population consisted of 28 surgical subjects (14 in conventional group and 14 in EGHEM group). Mean subject age was 73.4 ± 6.7 years (36% male) in conventional group and 65.9 ± 14.4 years (36% male) in EGHEM group. Procedures included orthopedic (conventional = 29%, EGHEM 36%), general (conventional = 50%, EGHEM = 36%), vascular (conventional = 7%, EGHEM = 21%), and thoracic (conventional = 14%, EGHEM = 7%). There was no statistically significant difference in adverse clinical events between the 2 groups. The EGHEM group had less CHF, atrial fibrillation, and shorter length of stay. CONCLUSIONS: Echocardiography-guided hemodynamic management of patients with LVDD during surgery is feasible and may be a safe alternative to conventional management.

"Never be wrong": the morbidity of negative and delayed laparotomies after blunt trauma.

BACKGROUND: The objective of this study was to investigate the 30-day morbidity of a negative laparotomy (NEGLAP) in blunt abdominal trauma. No previous work has exclusively examined blunt abdominal trauma patients, used a control group, or determined the complication burden incurred by a NEGLAP. METHODS: In this retrospective cohort study of a prospectively maintained database, demographics, Injury Severity Score, Revised Trauma Score (TRISS), hospital length of stay, mortality, and findings at laparotomy (LAP) were analyzed. Patients were assigned to four groups as follows: NEGLAP (n = 28), positive LAP (n = 126), delay to LAP (DELAY, n = 18), and no LAP (NOLAP, n = 427). Complications during hospitalization and 30 days postdischarge were extracted from our complication database and adjusted for severity using a complication scoring system (Complication Impact Score [CIS]). The effect of LAP on the log transformed CIS was assessed using a linear regression model, controlling for age and TRISS. RESULTS: Complications per patient ranged from 1.73 (DELAY) to 0.38 (NOLAP), and the average CIS per patient ranged from 7.29 (NEGLAP) to 1.8 (NOLAP). When controlled for TRISS and age, NEGLAP did not significantly increase the CIS (p = 0.620), whereas positive LAP (p = 0.004) and DELAY (p = 0.034) were associated with a significant increase in CIS. CONCLUSIONS: When controlled for TRISS and age, NEGLAP does not increase the complication burden compared with NOLAP. In blunt abdominal trauma patients, operations to establish diagnosis do not add significantly to complication burden.

High-pressure distention of the saphenous vein during preparation results in increased markers of inflammation: a potential mechanism for graft failure.

BACKGROUND: Coronary artery disease is the single leading cause of death in the United States. Commonly it is treated with coronary bypass grafting using the saphenous vein (SV) or internal mammary artery (IMA) as a conduit. Unfortunately, the SV has much lower patency rates compared with the IMA. Several hypotheses exist as to why occlusion occurs more commonly in SV grafts than in IMA grafts. However detailed studies in this area have been limited. This study investigates the effects of pressure distention on inflammation in SV conduit used in coronary artery bypass grafting (CABG). METHODS: Saphenous vein distention pressure was measured intraoperatively during 48 CABG procedures. A segment of SV was excised from the conduit before distention. Because the vein was used for coronary artery grafting, sequential pieces were archived for evaluation. Real-time polymerase chain reaction (RT-PCR) and immunohistochemical analyses were performed to investigate a change in the expression of biomarkers. RESULTS: Upregulation of various biomarkers occurred. These biomarkers included scavenger receptors A and B (SR-A, SR-B), toll-like receptors 2 and 4 (TLR2, TLR4), platelet endothelial cell adhesion molecule (PECAM), vascular cell adhesion molecule (VCAM), and intercellular cell adhesion molecule (ICAM) in segments of SV that were subjected to distention. Immunohistochemical results mirrored RT-PCR findings. A significant correlation was observed between biomarkers and pressure values. CONCLUSIONS: These studies demonstrate that markers of inflammation are upregulated in response to SV distention. The data suggest that the pressure used in graft preparation procedures should be regulated to avoid inflammation and its potential to induce graft failure.