Detalhe da pesquisa
1.
Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice.
Brain;
139(Pt 7): 2063-81, 2016 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27190010
2.
Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP-receptor selective scaffolds. Part II.
Bioorg Med Chem;
22(8): 2508-16, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24657054
3.
Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception.
FASEB J;
26(2): 947-54, 2012 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22038051
4.
Rodent motor and neuropsychological behaviour measured in home cages using the integrated modular platform SmartCage™.
Clin Exp Pharmacol Physiol;
39(7): 614-22, 2012 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22540540
5.
Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia.
J Clin Invest;
118(7): 2471-81, 2008 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18551194
6.
Differential effects of nociceptin/orphanin FQ (NOP) receptor agonists in acute versus chronic pain: studies with bifunctional NOP/µ receptor agonists in the sciatic nerve ligation chronic pain model in mice.
J Pharmacol Exp Ther;
339(2): 687-93, 2011 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21859931
7.
The first universal opioid ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): characterization of the in vitro profile and in vivo behavioral effects in mouse models of acute pain and cocaine-induced reward.
J Pharmacol Exp Ther;
336(3): 952-61, 2011 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21177476
8.
Nociceptin/orphanin FQ receptor activation attenuates antinociception induced by mixed nociceptin/orphanin FQ/mu-opioid receptor agonists.
J Pharmacol Exp Ther;
331(3): 946-53, 2009 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19713488
9.
Comparison of the antinociceptive and antirewarding profiles of novel bifunctional nociceptin receptor/mu-opioid receptor ligands: implications for therapeutic applications.
J Pharmacol Exp Ther;
331(3): 954-64, 2009 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19773529
10.
Rodent models of nicotine reward: what do they tell us about tobacco abuse in humans?
Pharmacol Biochem Behav;
91(4): 481-8, 2009 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19121334
11.
Genetics of nicotine dependence and pharmacotherapy.
Biochem Pharmacol;
75(1): 178-95, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17888884
12.
Synthesis, Biological Evaluation, and SAR Studies of 14ß-phenylacetyl Substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones Derivatives: Ligands With Mixed NOP and Opioid Receptor Profile.
Front Psychiatry;
9: 430, 2018.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30283364
13.
Anti-nociceptive and anti-allodynic effects of a high affinity NOP hexapeptide [Ac-RY(3-Cl)YRWR-NH2] (Syn 1020) in rodents.
Eur J Pharmacol;
560(1): 29-35, 2007 Mar 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17303110
14.
In Vitro and In Vivo Profile of PPL-101 and PPL-103: Mixed Opioid Partial Agonist Analgesics with Low Abuse Potential.
Front Psychiatry;
8: 52, 2017.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28446883
15.
Varenicline enhances dopamine release facilitation more than nicotine after long-term nicotine treatment and withdrawal.
Pharmacol Res Perspect;
3(1): e00105, 2015 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25692023
16.
High affinity α3ß4 nicotinic acetylcholine receptor ligands AT-1001 and AT-1012 attenuate cocaine-induced conditioned place preference and behavioral sensitization in mice.
Biochem Pharmacol;
97(4): 531-541, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26256075
17.
AT-1001: a high-affinity α3ß4 nAChR ligand with novel nicotine-suppressive pharmacology.
Br J Pharmacol;
172(7): 1834-45, 2015 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25440006
18.
Environmental and genetic determinants of tobacco use: methodology for a multidisciplinary, longitudinal family-based investigation.
Cancer Epidemiol Biomarkers Prev;
12(10): 994-1005, 2003 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14578134
19.
Design, chemical synthesis, and biological evaluation of thiosaccharide analogues of morphine- and codeine-6-glucuronide.
J Med Chem;
47(23): 5809-15, 2004 Nov 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15509180
20.
Attenuation of relapse to cocaine seeking by dopamine D1 receptor agonists and antagonists in non-human primates.
Psychopharmacology (Berl);
168(1-2): 124-131, 2003 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12607074