Detalhe da pesquisa
1.
Synthesis, biological evaluation and molecular modelling of 2,4-disubstituted-5-(6-alkylpyridin-2-yl)-1H-imidazoles as ALK5 inhibitors.
J Enzyme Inhib Med Chem;
35(1): 702-712, 2020 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32164459
2.
EW-7197, an activin-like kinase 5 inhibitor, suppresses granulation tissue after stent placement in rat esophagus.
Gastrointest Endosc;
86(1): 219-228, 2017 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28137596
3.
Novel oral transforming growth factor-ß signaling inhibitor EW-7197 eradicates CML-initiating cells.
Cancer Sci;
107(2): 140-8, 2016 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26583567
4.
TGF-ß Type I Receptor Kinase Inhibitor EW-7197 Suppresses Cholestatic Liver Fibrosis by Inhibiting HIF1α-Induced Epithelial Mesenchymal Transition.
Cell Physiol Biochem;
38(2): 571-88, 2016.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26845171
5.
EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-ß/Smad and ROS signaling.
Cell Mol Life Sci;
72(10): 2023-39, 2015 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25487606
6.
Synthesis and biological evaluation of 5-(fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles as inhibitors of transforming growth factor-ß type I receptor kinase.
Bioorg Med Chem Lett;
25(22): 5228-31, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26483198
7.
4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5(3)-(6-methylpyridin-2-yl)imidazole and -pyrazole derivatives as potent and selective inhibitors of transforming growth factor-ß type I receptor kinase.
Bioorg Med Chem;
22(9): 2724-32, 2014 May 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24704197
8.
Transforming growth factor-ß1 receptor inhibition preserves glomerulotubular integrity during ureteral obstruction in adults but worsens injury in neonatal mice.
Am J Physiol Renal Physiol;
304(5): F481-90, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23303407
9.
IN-1233-eluting covered metallic stent to prevent hyperplasia: experimental study in a rabbit esophageal model.
Radiology;
267(2): 396-404, 2013 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23315658
10.
Beneficial Effects of a Curcumin Derivative and Transforming Growth Factor-ß Receptor I Inhibitor Combination on Nonalcoholic Steatohepatitis.
Diabetes Metab J;
47(4): 500-513, 2023 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37096379
11.
Different routes of administering EW-7197 versus EW-7197â HBr for preventing peritoneal adhesion in a rat model.
Surgery;
173(4): 1008-1014, 2023 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36577598
12.
Vactosertib, TGF-ß receptor I inhibitor, augments the sensitization of the anti-cancer activity of gemcitabine in pancreatic cancer.
Biomed Pharmacother;
162: 114716, 2023 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37086509
13.
EW-7197 Attenuates the Progression of Diabetic Nephropathy in db/db Mice through Suppression of Fibrogenesis and Inflammation.
Endocrinol Metab (Seoul);
37(1): 96-111, 2022 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35255604
14.
Discovery of (E)-3-(3-((2-Cyano-4'-dimethylaminobiphenyl-4-ylmethyl)cyclohexanecarbonylamino)-5-fluorophenyl)acrylic Acid Methyl Ester, an Intestine-Specific, FXR Partial Agonist for the Treatment of Nonalcoholic Steatohepatitis.
J Med Chem;
65(14): 9974-10000, 2022 07 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35797110
15.
EW-7203, a novel small molecule inhibitor of transforming growth factor-ß (TGF-ß) type I receptor/activin receptor-like kinase-5, blocks TGF-ß1-mediated epithelial-to-mesenchymal transition in mammary epithelial cells.
Cancer Sci;
102(10): 1889-96, 2011 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21707864
16.
Role of IN-1233 in the prevention of neointimal hyperplasia after stent placement in a rat artery model.
J Vasc Interv Radiol;
22(9): 1321-8, 2011 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21515073
17.
Synthesis and biological evaluation of 1-substituted-3-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazoles as transforming growth factor-ß type 1 receptor kinase inhibitors.
Bioorg Med Chem Lett;
21(20): 6049-53, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21911290
18.
Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)pyrazoles as transforming growth factor-ß type 1 receptor kinase inhibitors.
Bioorg Med Chem;
19(8): 2633-40, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21435890
19.
Increased transforming growth factor beta 1 expression mediates ozone-induced airway fibrosis in mice.
Inhal Toxicol;
23(8): 486-94, 2011 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21689010
20.
Altered bone morphogenetic protein and transforming growth factor-beta signaling in rat models of pulmonary hypertension: potential for activin receptor-like kinase-5 inhibition in prevention and progression of disease.
Circulation;
119(4): 566-76, 2009 Feb 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19153267