Discovery of ursolic acid prodrug (NX-201): Pharmacokinetics and in vivo antitumor effects in PANC-1 pancreatic cancer.

The aim of our study was to develop ursolic acid (UA) prodrugs in order to overcome UA's weakness, which has an extremely low bioavailability. UA-medoxomil (NX-201), one of our UA prodrugs, showed an improved bioavailability about 200times better than UA in rodent model. According to in vivo test performed with PANC-1 xenograft SCID mouse model, tumor growth rate decreased dose-dependently and 100mg/kg dose of NX-201 had an anticancer effect comparable to gemcitabine. Most of all the combination of NX-201 (50mg/kg, po, daily) and gemcitabine (40mg/kg, iv, 2timesperweek) even reduced tumor size after three weeks.

Synthesis and Characterization of the Donor-Acceptor Conjugated Polymer PBDB-T Implementing Group IV Element Germanium.

Here, we synthesized and characterized a novel two-dimensional (2D) conjugated electron donor-acceptor (D-A) copolymer (PBDB-T-Ge), wherein the substituent of triethyl germanium was added to the electron donor unit of the polymer. The Turbo-Grignard reaction was used to implement the group IV element into the polymer, resulting in a yield of 86%. This corresponding polymer, PBDB-T-Ge, exhibited a down-shift in the highest occupied molecular orbital (HOMO) level to -5.45 eV while the lowest unoccupied molecular orbital (LUMO) level was -3.64 eV. The peaks in UV-Vis absorption and the PL emission of PBDB-T-Ge were observed at 484 nm and 615 nm, respectively.

Development of a soft x-ray (SXR) array diagnostic system on versatile experiment spherical torus (VEST).

A new soft x-ray (SXR) array diagnostic system has been developed on versatile experiment spherical torus (VEST) for measurements of 2D SXR emissivity profile and identification of poloidal mode structure. Through tomographic inversion techniques, 2D SXR emissivity profile can be acquired from the line-integrated SXR data, which enables the visualization of mode structure of plasma instability, such as the magnetohydrodynamics mode. The SXR array diagnostic system consists of two 20-channel arrays positioned at the middle and the top on the same poloidal plane for horizontal and vertical lines of sight, respectively. Each array of the diagnostic system uses absolute extreme ultraviolet photodiode array as the detector. To apply appropriate filters (up to four) for different energy regimes without breaking the vacuum, a filter wheel and its rotatable vacuum feed-through are installed behind the pinhole. SXR data are acquired with a digitizer at the sampling rate of up to 125 MHz. Finally, we discuss initial measurement data obtained from Ohmic plasma in VEST.

Secondary Dopants of Electrically Conducting Polyanilines.

Secondary dopants and the doping methods were identified for increasing the electrical conductivity of a highly processable and a primarily doped polyaniline dinonylnaphthalene sulfonic acid (PANI-DNNSA). The secondary doping was carried out using film, solution, and vapor doping methods. The doping methods and functional groups of secondary dopants were observed to play a critical role for inducing electrical characteristics of polyaniline. When secondary film doping method and p-toluenesulfonic acid were used, the electrical conductivity of the secondary doped polyaniline was measured to be increased from 0.16 to 334 S/cm. A novel vapor annealing doping method was developed to incorporate secondary dopants into solution cast polyaniline films.

Radial profile measurement with an improved 1 kHz Thomson scattering system on Versatile Experiment Spherical Torus.

A Thomson scattering (TS) system has been utilized to measure the electron temperature and density of the core region of Versatile Experiment Spherical Torus (VEST). Recently, the laser injection system is successfully upgraded adopting the burst laser with the repetition rate of 1 kHz and the energy of 2 J. Furthermore, improved collection optics with additional polychromators and a 32-channel fast digitizer are prepared to observe the fast time evolution of radial profiles. This improvement is essential to study fast phenomena such as internal reconnection event (IRE). We increase the TS signal and reduce the stray light by introducing new filters having better optical properties such as high optical density at 1064 nm, transmission, and reflectance. Moreover, the optimum reverse bias voltages are newly set to make the system operational independent of the background radiation. As a result, 1 kHz radial profiles of the core electron temperature and density are measured for the first time, showing characteristics of IREs in VEST.

Evidence of a turbulent ExB mixing avalanche mechanism of gas breakdown in strongly magnetized systems.

Although gas breakdown phenomena have been intensively studied over 100 years, the breakdown mechanism in a strongly magnetized system, such as tokamak, has been still obscured due to complex electromagnetic topologies. There has been a widespread misconception that the conventional breakdown model of the unmagnetized system can be directly applied to the strongly magnetized system. However, we found clear evidence that existing theories cannot explain the experimental results. Here, we demonstrate the underlying mechanism of gas breakdown in tokamaks, a turbulent ExB mixing avalanche, which systematically considers multi-dimensional plasma dynamics in the complex electromagnetic topology. This mechanism clearly elucidates the experiments by identifying crucial roles of self-electric fields produced by space-charge that decrease the plasma density growth rate and cause a dominant transport via ExB drifts. A comprehensive understanding of plasma dynamics in complex electromagnetic topology provides general design strategy for robust breakdown scenarios in a tokamak fusion reactor.

Platinum-acetylide polymer based solar cells: involvement of the triplet state for energy conversion.

Relatively efficient photovoltaic devices were fabricated using blends of a phosphorescent platinum-acetylide polymer and a fullerene (PCBM); involvement of the triplet excited state of the platinum-acetylide polymer in photoinduced charge transfer is believed to contribute to the device efficiency.

Electron density profile measurements from hydrogen line intensity ratio method in Versatile Experiment Spherical Torus.

Electron density profiles of versatile experiment spherical torus plasmas are measured by using a hydrogen line intensity ratio method. A fast-frame visible camera with appropriate bandpass filters is used to detect images of Balmer line intensities. The unique optical system makes it possible to take images of Hα and Hß radiation simultaneously, with only one camera. The frame rate is 1000 fps and the spatial resolution of the system is about 0.5 cm. One-dimensional local emissivity profiles have been obtained from the toroidal line of sight with viewing dumps. An initial result for the electron density profile is presented and is in reasonable agreement with values measured by a triple Langmuir probe.

Low-band-gap platinum acetylide polymers as active materials for organic solar cells.

We report on two pairs of platinum acetylide based polymers and model oligomers utilizing a 2,1,3-benzothiadiazole (BTD) acceptor moiety flanked on either side by either 2,5-thienyl donor units (Pt2BTD-Th and p-PtBTD-Th) or (3,4-ethylenedioxy)-2,5-thienyl donors (Pt2BTD-EDOT and p-PtBTD-EDOT). Both oligomer/polymer pairs absorb strongly throughout the visible region; however, because the (ethylenedioxy)thiophene moiety is a stronger donor than thiophene, the latter oligomer/polymer pair has a correspondingly lower band gap and, therefore, harvests light more efficiently at longer wavelengths. p-PtBTD-Th exhibits a relatively narrow molecular weight distribution with a number-average molecular weight (Mn) of 22 kDa, while p-PtBTD-EDOT exhibits a comparable Mn of 33 kDa but has a high polydispersity index likely due to aggregation. We provide a complete report of the photophysical and electrochemical characterization of the two oligomer/polymer pairs. The photophysical studies reveal that the materials undergo relatively efficient intersystem crossing. In a discussion of the energetics of photoinduced electron transfer from the platinum polymers to [6,6]-phenyl C61 butyric acid methyl ester (PCBM), it is noted that while the singlet state is quenched efficiently, the triplet state is not quenched, indicating that charge generation in the photovoltaic materials must ensue from the singlet manifold. Finally, organic photovoltaic devices based on blends of p-PtBDT-Th or p-PtBDT-EDOT with PCBM were characterized under monochromatic and simulated solar (AM1.5) illumination. Optimized devices exhibit an open-circuit voltage (Voc) of approximately 0.5 V, a short-circuit current density (Isc) of approximately 7.2 mA cm(-2), and a fill factor of approximately 35%, which yields overall power conversion efficiencies of 1.1-1.4%.

A newly designed single etalon double edge Doppler wind lidar receiving optical system.

A new optical Doppler lidar receiving system which can measure Doppler-shifted incoherent scattering light has been proposed and tested. This system functions in a manner similar to two edge filters and consists of a single etalon, a polarization beam splitter, and mirrors that can guide scattered light into a single etalon with two different angles. These two incident angles are precisely adjusted by the polarization beam splitter and mirrors. Using this optical receiving system we can measure a moving target with a high sensitivity. Theoretical calculations show that this system will have a better optical sensitivity than a single edge system and will allow the use of incoherent Doppler lidar for wind velocity measurements.

A fulleropyrrolidine end-capped platinum-acetylide triad: the mechanism of photoinduced charge transfer in organometallic photovoltaic cells.

The fullerene end-capped platinum acetylide donor-acceptor triad Pt(2)ThC(60) was synthesized and characterized by using photophysical methods and photovoltaic device testing. The triad consists of the platinum acetylide oligomer Ph-[triple bond, length as m-dash]-Pt(PBu3)2-[triple bond, length as m-dash]-Th-[triple bond, length as m-dash]-Pt(PBu3)2-[triple bond, length as m-dash]-Ph (Ph=phenyl and Th=2,5-thienyl, stereochemistry at both Pt centers is trans) that contains fulleropyrrolidine moieties on each of the terminal phenylene units. Electrochemistry of the triad reveals relatively low potential oxidation and reduction waves corresponding, respectively, to oxidation of the platinum acetylide and reduction of the fulleropyrrolidine units. Photoluminescence spectroscopy shows that the singlet and triplet states of the platinum acetylide chromophore are strongly quenched in the triad assembly, both in solution at ambient temperature as well as in a low-temperature solvent glass. The excited state quenching arises due to intramolecular photoinduced electron transfer to produce a charge separated state based on charge transfer from the platinum acetylide (donor) to the fulleropyrrolidine (acceptor). Picosecond time resolved absorption spectroscopy confirms that the charge transfer state is produced within 1 ps of photoexcitation, and it decays by charge recombination within 400 ps. Organic photovoltaic devices fabricated using spin-coated films of Pt2ThC60 as the active material operate with modest efficiency, exhibiting a short circuit photocurrent of 0.51 mA cm(-2) and an open circuit voltage of 0.41 V under 100 mW cm(-2)/AM1.5 illumination. The results are discussed in terms of the relationship between the mechanism of photoinduced electron transfer in the triad and the comparatively efficient photovoltaic response exhibited by the material.

Soluble narrow band gap and blue propylenedioxythiophene-cyanovinylene polymers as multifunctional materials for photovoltaic and electrochromic applications.

A family of soluble narrow band gap donor-acceptor conjugated polymers based on dioxythiophenes and cyanovinylenes is reported. The polymers were synthesized using Knoevenagel polycondensation or Yamamoto coupling polymerizations to yield polymers with molecular weights on the order of 10 000-20 000 g/mol, which possess solubility in common organic solvents. Thin film optical measurements revealed narrow band gaps of 1.5-1.8 eV, which gives the polymers a strong overlap of the solar spectrum. The energetic positions of the band edges were determined by cyclic voltammetry and differential pulse voltammetry and demonstrate that the polymers are both air stable and show a strong propensity for photoinduced charge transfer to fullerene acceptors. Such measurements also suggest that the polymers can be both p- and n-type doped, which is supported by spectroelectrochemical results. These polymers have been investigated as electron donors in photovoltaic devices in combination with PCBM ([6,6]-phenyl C(61)-butyric acid methyl ester) as an electron acceptor based on the near ideal band structures designed into the polymers. Efficiencies as high as 0.2% (AM1.5) with short circuit current densities as high as 1.2-1.3 mA/cm(2) have been observed in polymer/PCBM (1:4 by weight) devices and external quantum efficiencies of more than 10% have been observed at wavelengths longer than 600 nm. The electrochromic properties of the narrow band gap polymers are also of interest as the polymers show three accessible color states changing from an absorptive blue or purple in the neutral state to a transmissive sky-blue or gray in the oxidized and reduced forms. The wide electrochemical range of electrochromic activity coupled with the strong observed changes in transmissivity between oxidation states makes these materials potentially interesting for application to electrochromic displays.