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Single-value scores reflecting the deviation from (FADE score) or similarity with (SAME score) prototypical novelty-related and memory-related functional magnetic resonance imaging (fMRI) activation patterns in young adults have been proposed as imaging biomarkers of healthy neurocognitive aging. Here, we tested the utility of these scores as potential diagnostic and prognostic markers in Alzheimer's disease (AD) and risk states like mild cognitive impairment (MCI) or subjective cognitive decline (SCD). To this end, we analyzed subsequent memory fMRI data from individuals with SCD, MCI, and AD dementia as well as healthy controls (HC) and first-degree relatives of AD dementia patients (AD-rel) who participated in the multi-center DELCODE study (N = 468). Based on the individual participants' whole-brain fMRI novelty and subsequent memory responses, we calculated the FADE and SAME scores and assessed their association with AD risk stage, neuropsychological test scores, CSF amyloid positivity, and ApoE genotype. Memory-based FADE and SAME scores showed a considerably larger deviation from a reference sample of young adults in the MCI and AD dementia groups compared to HC, SCD and AD-rel. In addition, novelty-based scores significantly differed between the MCI and AD dementia groups. Across the entire sample, single-value scores correlated with neuropsychological test performance. The novelty-based SAME score further differed between Aß-positive and Aß-negative individuals in SCD and AD-rel, and between ApoE ε4 carriers and non-carriers in AD-rel. Hence, FADE and SAME scores are associated with both cognitive performance and individual risk factors for AD. Their potential utility as diagnostic and prognostic biomarkers warrants further exploration, particularly in individuals with SCD and healthy relatives of AD dementia patients.
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Memory-related functional magnetic resonance imaging (fMRI) activations show age-related differences across multiple brain regions that can be captured in summary statistics like single-value scores. Recently, we described two single-value scores reflecting deviations from prototypical whole-brain fMRI activity of young adults during novelty processing and successful encoding. Here, we investigate the brain-behavior associations of these scores with age-related neurocognitive changes in 153 healthy middle-aged and older adults. All scores were associated with episodic recall performance. The memory network scores, but not the novelty network scores, additionally correlated with medial temporal gray matter and other neuropsychological measures including flexibility. Our results thus suggest that novelty-network-based fMRI scores show high brain-behavior associations with episodic memory and that encoding-network-based fMRI scores additionally capture individual differences in other aging-related functions. More generally, our results suggest that single-value scores of memory-related fMRI provide a comprehensive measure of individual differences in network dysfunction that may contribute to age-related cognitive decline.
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Envelhecimento , Memória Episódica , Pessoa de Meia-Idade , Adulto Jovem , Humanos , Idoso , Envelhecimento/psicologia , Encéfalo/diagnóstico por imagem , Rememoração Mental , Mapeamento Encefálico , Imageamento por Ressonância Magnética/métodos , Testes NeuropsicológicosRESUMO
The default mode network (DMN) typically exhibits deactivations during demanding tasks compared to periods of relative rest. In functional magnetic resonance imaging (fMRI) studies of episodic memory encoding, increased activity in DMN regions even predicts later forgetting in young healthy adults. This association is attenuated in older adults and, in some instances, increased DMN activity even predicts remembering rather than forgetting. It is yet unclear whether this phenomenon is due to a compensatory mechanism, such as self-referential or schema-dependent encoding, or whether it reflects overall reduced DMN activity modulation in older age. We approached this question by systematically comparing DMN activity during successful encoding and tonic, task-independent, DMN activity at rest in a sample of 106 young (18-35 years) and 111 older (60-80 years) healthy participants. Using voxel-wise multimodal analyses, we assessed the age-dependent relationship between DMN resting-state amplitude (mean percent amplitude of fluctuation, mPerAF) and DMN fMRI signals related to successful memory encoding, as well as their modulation by age-related hippocampal volume loss, while controlling for regional grey matter volume. Older adults showed lower resting-state DMN amplitudes and lower task-related deactivations. However, a negative relationship between resting-state mPerAF and subsequent memory effect within the precuneus was observed only in young, but not older adults. Hippocampal volumes showed no relationship with the DMN subsequent memory effect or mPerAF. Lastly, older adults with higher mPerAF in the DMN at rest tend to show higher memory performance, pointing towards the importance of a maintained ability to modulate DMN activity in old age.
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Mapeamento Encefálico , Encéfalo , Humanos , Idoso , Encéfalo/diagnóstico por imagem , Rede de Modo Padrão , Cognição , Rememoração Mental , Imageamento por Ressonância Magnética , Rede NervosaRESUMO
BACKGROUND: Alzheimer's disease (AD) is often preceded by stages of cognitive impairment, namely subjective cognitive decline (SCD) and mild cognitive impairment (MCI). While cerebrospinal fluid (CSF) biomarkers are established predictors of AD, other non-invasive candidate predictors include personality traits, anxiety, and depression, among others. These predictors offer non-invasive assessment and exhibit changes during AD development and preclinical stages. METHODS: In a cross-sectional design, we comparatively evaluated the predictive value of personality traits (Big Five), geriatric anxiety and depression scores, resting-state functional magnetic resonance imaging activity of the default mode network, apoliprotein E (ApoE) genotype, and CSF biomarkers (tTau, pTau181, Aß42/40 ratio) in a multi-class support vector machine classification. Participants included 189 healthy controls (HC), 338 individuals with SCD, 132 with amnestic MCI, and 74 with mild AD from the multicenter DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE). RESULTS: Mean predictive accuracy across all participant groups was highest when utilizing a combination of personality, depression, and anxiety scores. HC were best predicted by a feature set comprised of depression and anxiety scores and participants with AD were best predicted by a feature set containing CSF biomarkers. Classification of participants with SCD or aMCI was near chance level for all assessed feature sets. CONCLUSION: Our results demonstrate predictive value of personality trait and state scores for AD. Importantly, CSF biomarkers, personality, depression, anxiety, and ApoE genotype show complementary value for classification of AD and its at-risk stages.
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Doença de Alzheimer , Disfunção Cognitiva , Idoso , Humanos , Doença de Alzheimer/psicologia , Peptídeos beta-Amiloides/líquido cefalorraquidiano , Ansiedade , Apolipoproteínas E/genética , Biomarcadores/líquido cefalorraquidiano , Disfunção Cognitiva/psicologia , Estudos Transversais , Depressão , Aprendizado de Máquina , PersonalidadeRESUMO
The aim of the present study was to investigate the acquisition of ditransitive structures beyond production. We conducted an elicitation task (production) and a picture-sentence matching task measuring accuracy and response times (comprehension). We examined German five-to seven-year-old typically developing children and an adult control group. Our data showed quasi-perfect performance in comprehension in adults and in those children who had already mastered ditransitives productively. However, children who had not yet mastered the production of ditransitives showed comprehension abilities preceding production abilities. Unlike adults, in the comprehension task children did not react explicitly before the end of the auditory stimulus.
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Transtornos do Desenvolvimento da Linguagem , Desenvolvimento da Linguagem , Adulto , Criança , Humanos , Pré-Escolar , Compreensão/fisiologia , Idioma , Linguagem InfantilRESUMO
It has been proposed that the deployment of selective attention to perceptual and memory representations might be governed by similar cognitive processes and neural resources. However, evidence for this simple and appealing proposal remains inconclusive, which might be due to a considerable divergence in tasks and cognitive demands when comparing attentional selection in memory versus perception. To examine whether selection in both domains share common attentional processes and only differ in the stimuli they act upon (external vs. internal), we compared behavioral costs or benefits between selection domains. In both domains, participants had to attend a target stimulus from a set of simultaneously presented stimuli or simultaneously active memory representations, respectively, with set, target, or both, being repeated or changed across trials. The results of two experiments delineated principal similarities and differences of selection processes in both domains: While positive priming from stimulus repetition was found in both selection domains, we found no consistent effects of negative priming when shifting the focus of attention to a previously to-be-ignored stimulus. However, priming in the perception task was mainly due to repetitions of the target feature (here: color), whereas for the memory task, repetition of the same set of stimulus representations was most important. We propose that the differences can be attributed to a reduced cognitive effort when the now relevant memory representation had already been pre-activated (even as a distractor) in the previous trial. Additionally, our experiments both underscore the importance of taking stimulus-response associations into account, which may be a hidden factor behind differences between domains. We conclude that any attempt of comparing internal versus external attentional selection has to consider inherent differences in selection dynamics across representational domains.
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Atenção , Percepção , Humanos , Percepção VisualRESUMO
Subsequent memory paradigms allow to identify neural correlates of successful encoding by separating brain responses as a function of memory performance during later retrieval. In functional magnetic resonance imaging (fMRI), the paradigm typically elicits activations of medial temporal lobe, prefrontal and parietal cortical structures in young, healthy participants. This categorical approach is, however, limited by insufficient memory performance in older and particularly memory-impaired individuals. A parametric modulation of encoding-related activations with memory confidence could overcome this limitation. Here, we applied cross-validated Bayesian model selection (cvBMS) for first-level fMRI models to a visual subsequent memory paradigm in young (18-35 years) and older (51-80 years) adults. Nested cvBMS revealed that parametric models, especially with non-linear transformations of memory confidence ratings, outperformed categorical models in explaining the fMRI signal variance during encoding. We thereby provide a framework for improving the modeling of encoding-related activations and for applying subsequent memory paradigms to memory-impaired individuals.
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Encéfalo/diagnóstico por imagem , Encéfalo/fisiologia , Imageamento por Ressonância Magnética/métodos , Memória/fisiologia , Modelos Neurológicos , Estimulação Luminosa/métodos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Teorema de Bayes , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto JovemRESUMO
Older adults and particularly those at risk for developing dementia typically show a decline in episodic memory performance, which has been associated with altered memory network activity detectable via functional magnetic resonance imaging (fMRI). To quantify the degree of these alterations, a score has been developed as a putative imaging biomarker for successful aging in memory for older adults (Functional Activity Deviations during Encoding, FADE; Düzel et al., Hippocampus, 2011; 21: 803-814). Here, we introduce and validate a more comprehensive version of the FADE score, termed FADE-SAME (Similarity of Activations during Memory Encoding), which differs from the original FADE score by considering not only activations but also deactivations in fMRI contrasts of stimulus novelty and successful encoding, and by taking into account the variance of young adults' activations. We computed both scores for novelty and subsequent memory contrasts in a cohort of 217 healthy adults, including 106 young and 111 older participants, as well as a replication cohort of 117 young subjects. We further tested the stability and generalizability of both scores by controlling for different MR scanners and gender, as well as by using different data sets of young adults as reference samples. Both scores showed robust age-group-related differences for the subsequent memory contrast, and the FADE-SAME score additionally exhibited age-group-related differences for the novelty contrast. Furthermore, both scores correlate with behavioral measures of cognitive aging, namely memory performance. Taken together, our results suggest that single-value scores of memory-related fMRI responses may constitute promising biomarkers for quantifying neurocognitive aging.
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Encéfalo/fisiologia , Envelhecimento Cognitivo/fisiologia , Neuroimagem Funcional/métodos , Hipocampo/fisiologia , Memória Episódica , Adolescente , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Encéfalo/diagnóstico por imagem , Feminino , Hipocampo/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Adulto JovemRESUMO
Activation of parietal cortex structures like the precuneus is commonly observed during explicit memory retrieval, but the role of parietal cortices in encoding has only recently been appreciated and is still poorly understood. Considering the importance of the precuneus in human visual attention and imagery, we aimed to assess a potential role for the precuneus in the encoding of visuospatial representations into long-term memory. We therefore investigated the acquisition of constant versus repeatedly shuffled configurations of icons on background images over five subsequent days in 32 young, healthy volunteers. Functional magnetic resonance imaging was conducted on Days 1, 2, and 5, and persistent memory traces were assessed by a delayed memory test after another 5 days. Constant compared to shuffled configurations were associated with significant improvement of position recognition from Day 1 to 5 and better delayed memory performance. Bilateral dorsal precuneus activations separated constant from shuffled configurations from Day 2 onward, and coactivation of the precuneus and hippocampus dissociated recognized and forgotten configurations, irrespective of condition. Furthermore, learning of constant configurations elicited increased functional coupling of the precuneus with dorsal and ventral visual stream structures. Our results identify the precuneus as a key brain structure in the acquisition of detailed visuospatial information by orchestrating a parieto-occipito-temporal network.
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Aprendizagem por Associação/fisiologia , Memória/fisiologia , Lobo Parietal/fisiologia , Percepção Espacial/fisiologia , Percepção Visual/fisiologia , Adulto , Mapeamento Encefálico , Feminino , Hipocampo/diagnóstico por imagem , Hipocampo/fisiologia , Humanos , Estudos Longitudinais , Imageamento por Ressonância Magnética , Masculino , Rede Nervosa/diagnóstico por imagem , Rede Nervosa/fisiologia , Lobo Parietal/diagnóstico por imagem , Estimulação Luminosa , Desempenho Psicomotor , Adulto JovemRESUMO
Sudden comprehension-or insight-during problem-solving can enhance learning, but the underlying neural processes are largely unknown. We investigated neural correlates of learning from sudden comprehension using functional magnetic resonance imaging and a verbal problem-solving task. Solutions and "solutions" to solvable and unsolvable verbal problems, respectively, were presented to induce sudden comprehension or continued incomprehension. We found activations of the hippocampus, medial prefrontal cortex (mPFC), amygdala, and striatum during sudden comprehension. Notably, however, mPFC and temporo-parietal neocortical structures rather than the hippocampus were associated with later learning of suddenly comprehended solutions. Moreover, difficult compared to easy sudden comprehension elicited midbrain activations and was associated with successful learning, pointing to learning via intrinsic reward. Sudden comprehension of novel semantic associations may constitute a special case of long-term memory formation primarily mediated by the mPFC, expanding our knowledge of its role in prior-knowledge-dependent memory.
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Associação , Compreensão/fisiologia , Hipocampo/fisiologia , Memória de Longo Prazo/fisiologia , Córtex Pré-Frontal/fisiologia , Resolução de Problemas/fisiologia , Adulto , Feminino , Hipocampo/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética , Masculino , Córtex Pré-Frontal/diagnóstico por imagem , Semântica , Adulto JovemRESUMO
It has been proposed that sudden insight into the solutions of problems can enhance long-term memory for those solutions. However, the nature of insight has been operationalized differently across studies. Here, we examined two main aspects of insight problem-solving-the generation of a solution and the subjective "aha!" experience-and experimentally evaluated their respective relationships to long-term memory formation (encoding). Our results suggest that generation (generated solution vs. presented solution) and the "aha!" experience ("aha!" vs. no "aha!") are independently related to learning from insight, as well as to the emotional response towards understanding the solution during encoding. Moreover, we analyzed the relationship between generation and the "aha!" experience and two different kinds of later memory tests, direct (intentional) and indirect (incidental). Here, we found that the generation effect was larger for indirect testing, reflecting more automatic retrieval processes, while the relationship with the occurrence of an "aha!" experience was somewhat larger for direct testing. Our results suggest that both the generation of a solution and the subjective experience of "aha!" indicate processes that benefit long-term memory formation, though differently. This beneficial effect is possibly due to the intrinsic reward associated with sudden comprehension and the detection of schema-consistency, i.e., that novel information can be easily integrated into existing knowledge.
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Conscientização/fisiologia , Compreensão , Criatividade , Rememoração Mental/fisiologia , Resolução de Problemas/fisiologia , Tomada de Decisões , Emoções , Humanos , Masculino , Memória de Longo Prazo/fisiologiaRESUMO
How do we control the successive retrieval of behaviorally relevant information from long-term memory (LTM) without being distracted by other potential retrieval targets associated to the same retrieval cues? Here, we approach this question by investigating the nature of trial-by-trial dynamics of selective LTM retrieval, i.e., in how far retrieval in one trial has detrimental or facilitatory effects on selective retrieval in the following trial. Participants first learned associations between retrieval cues and targets, with one cue always being linked to three targets, forming small associative networks. In successive trials, participants had to access either the same or a different target belonging to either the same or a different cue. We found that retrieval times were faster for targets that had already been relevant in the previous trial, with this facilitatory effect being substantially weaker when the associative network changed in which the targets were embedded. Moreover, staying within the same network still had a facilitatory effect even if the target changed, which became evident in a relatively higher memory performance in comparison to a network change. Furthermore, event-related brain potentials (ERPs) showed topographically and temporally dissociable correlates of these effects, suggesting that they result from combined influences of distinct processes that aid memory retrieval when relevant and irrelevant targets change their status from trial to trial. Taken together, the present study provides insight into the different processing stages of memory retrieval when fast switches between retrieval targets are required.
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Encéfalo/fisiologia , Memória de Longo Prazo/fisiologia , Rememoração Mental/fisiologia , Adolescente , Adulto , Sinais (Psicologia) , Eletroencefalografia , Feminino , Humanos , Masculino , Adulto JovemRESUMO
Episodic memory performance declines with increasing age, and older adults typically show reduced activation of inferior temporo-parietal cortices in functional magnetic resonance imaging (fMRI) studies of episodic memory formation. Given the age-related cortical volume loss, it is conceivable that age-related reduction of memory-related fMRI activity may be partially attributable to reduced grey matter volume (GMV). We performed a voxel-wise multimodal neuroimaging analysis of fMRI correlates of successful memory encoding, using regional GMV as covariate. In a large cohort of healthy adults (106 young, 111 older), older adults showed reduced GMV across the entire neocortex and reduced encoding-related activation of inferior temporal and parieto-occipital cortices compared to young adults. Importantly, these reduced fMRI activations during successful encoding could in part be attributed to lower regional GMV. Our results highlight the importance of controlling for structural MRI differences in fMRI studies in older adults but also demonstrate that age-related differences in memory-related fMRI activity cannot be attributed to structural variability alone.
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Substância Cinzenta , Memória Episódica , Humanos , Idoso , Substância Cinzenta/diagnóstico por imagem , Substância Cinzenta/patologia , Imageamento por Ressonância Magnética/métodos , Envelhecimento/fisiologia , Córtex Cerebral , Neuroimagem , Encéfalo/diagnóstico por imagem , Encéfalo/fisiologiaRESUMO
Successful explicit memory encoding is associated with inferior temporal activations and medial parietal deactivations, which are attenuated in aging. Here we used dynamic causal modeling (DCM) of functional magnetic resonance imaging data to elucidate effective connectivity patterns between hippocampus, parahippocampal place area (PPA), and precuneus during encoding of novel visual scenes. In 117 young adults, DCM revealed pronounced activating input from the PPA to the hippocampus and inhibitory connectivity from the PPA to the precuneus during novelty processing, with both being enhanced during successful encoding. This pattern could be replicated in two cohorts (N = 141 and 148) of young and older adults. In both cohorts, older adults selectively exhibited attenuated inhibitory PPA-precuneus connectivity, which correlated negatively with memory performance. Our results provide insight into the network dynamics underlying explicit memory encoding and suggest that age-related differences in memory-related network activity are, at least partly, attributable to altered temporo-parietal neocortical connectivity.
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Human cognitive abilities decline with increasing chronological age, with decreased explicit memory performance being most strongly affected. However, some older adults show "successful aging," that is, relatively preserved cognitive ability in old age. One explanation for this could be higher brain-structural integrity in these individuals. Alternatively, the brain might recruit existing resources more efficiently or employ compensatory cognitive strategies. Here, we approached this question by testing multiple candidate variables from structural and functional neuroimaging for their ability to predict chronological age and memory performance, respectively. Prediction was performed using support vector machine (SVM) classification and regression across and within two samples of young (N = 106) and older (N = 153) adults. The candidate variables were (1) behavioral response frequencies in an episodic memory test; (2) recently described functional magnetic resonance imaging (fMRI) scores reflecting preservation of functional memory networks; (3) whole-brain fMRI contrasts for novelty processing and subsequent memory; (4) resting-state fMRI maps quantifying voxel-wise signal fluctuation; and (5) gray matter volume estimated from structural MRIs. While age group could be reliably decoded from all variables, chronological age within young and older subjects was best predicted from gray matter volume. In contrast, memory performance was best predicted from task-based fMRI contrasts and particularly single-value fMRI scores, whereas gray matter volume has no predictive power with respect to memory performance in healthy adults. Our results suggest that superior memory performance in healthy older adults is better explained by efficient recruitment of memory networks rather than by preserved brain structure.
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Imageamento por Ressonância Magnética , Memória Episódica , Humanos , Idoso , Cognição/fisiologia , Encéfalo/fisiologia , Mapeamento Encefálico , Envelhecimento/fisiologiaRESUMO
BACKGROUND AND OBJECTIVES: We assessed whether novelty-related fMRI activity in medial temporal lobe regions and the precuneus follows an inverted U-shaped pattern across the clinical spectrum of increased Alzheimer disease (AD) risk as previously suggested. Specifically, we tested for potentially increased activity in individuals with a higher AD risk due to subjective cognitive decline (SCD) or mild cognitive impairment (MCI). We further tested whether activity differences related to diagnostic groups were accounted for by CSF markers of AD or brain atrophy. METHODS: We studied 499 participants aged 60-88 years from the German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia Study (DELCODE) who underwent task-fMRI. Participants included 163 cognitively normal (healthy control, HC) individuals, 222 SCD, 82 MCI, and 32 patients with clinical diagnosis of mild AD. CSF levels of ß-amyloid 42/40 ratio and phosphorylated-tau181 were available from 232 participants. We used region-based analyses to assess novelty-related activity (novel > highly familiar scenes) in entorhinal cortex, hippocampus, and precuneus as well as whole-brain voxel-wise analyses. First, general linear models tested differences in fMRI activity between participant groups. Complementary regression models tested quadratic relationships between memory impairment and activity. Second, relationships of activity with AD CSF biomarkers and brain volume were analyzed. Analyses were controlled for age, sex, study site, and education. RESULTS: In the precuneus, we observed an inverted U-shaped pattern of novelty-related activity across groups, with higher activity in SCD and MCI compared with HC, but not in patients with AD who showed relatively lower activity than MCI. This nonlinear pattern was confirmed by a quadratic relationship between memory impairment and precuneus activity. Precuneus activity was not related to AD biomarkers or brain volume. In contrast to the precuneus, hippocampal activity was reduced in AD dementia compared with all other groups and related to AD biomarkers. DISCUSSION: Novelty-related activity in the precuneus follows a nonlinear pattern across the clinical spectrum of increased AD risk. Although the underlying mechanism remains unclear, increased precuneus activity might represent an early signature of memory impairment. Our results highlight the nonlinearity of activity alterations that should be considered in clinical trials using functional outcome measures or targeting hyperactivity.
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Doença de Alzheimer , Disfunção Cognitiva , Doença de Alzheimer/diagnóstico , Peptídeos beta-Amiloides , Biomarcadores , Disfunção Cognitiva/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética/métodos , Lobo Parietal/diagnóstico por imagem , Lobo Temporal/diagnóstico por imagemRESUMO
The present pilot study investigated potential effects of early and late child bilingualism in highly proficient adult bilinguals. It has been shown that some early second language (eL2) speakers stagnate when it comes to complex linguistic phenomena and that they display subtle difficulties in adulthood. Therefore, we have chosen the complex structure of double object constructions. We investigate the long-term achievement in a combined-method approach using elicited production, explicit comprehension by sentence-picture matching and a measure of implicit linguistic knowledge, namely pupillometry. This eye tracking method is suitable for measuring implicit reactions of the pupils to unexpected or ungrammatical stimuli. For production, ditransitive structures were elicited by means of a game. For comprehension, a sentence-picture matching task was conducted. Two pictures were shown on a monitor that were equal with respect to the involved objects, but the thematic roles of direct and indirect objects were interchanged. Items were controlled for length, gender, animacy, semantic likelihood and word order. Reaction times and accuracy scores were analyzed. To this end, N = 18 bilingual adult speakers of German (+ another language, mean age: 26.5) with different ages of onset participated in this study and were compared to N = 26 monolingual German adult speakers (mean age 23.9). All participants had a proficiency of German above 89% correct in placement and cloze tests. Results show fully comparable productive and comprehensive competencies in monolinguals and bilinguals including the reaction times in the sentence-picture matching task and a word order effect on the reaction times in both groups. In the pupillometry task, we found monolinguals and bilinguals to be sensitive to differing conditions with respect to grammatical and ungrammatical utterances. However, we find between group differences in pupil dilations in that bilinguals react differently to strong grammatical violations than monolinguals. These results are discussed with respect to the term of native speaker competence and the variation within both groups.
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[This corrects the article DOI: 10.3389/fpsyg.2021.717379.].
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Several cognitive functions show a decline with advanced age, most prominently episodic memory. Problem-solving by insight represents a special associative form of problem-solving that has previously been shown to facilitate long-term memory formation. Recent neuroimaging evidence suggests that the encoding network involved in insight-based memory formation is largely hippocampus-independent. This may represent a potential advantage in older adults, as the hippocampus is one of the earliest brain structures to show age-related volume loss and functional impairment. Here, we investigated the potential beneficial effects of learning by insight in healthy older (60-79 years) compared to young adults (19-28 years). To this end, we compared later memory performance for verbal riddles encoded incidentally via induced insight-like sudden comprehension in both age groups. We employed a variant of the Compound Remote Associate Task (CRAT) for incidental encoding, during which participants were instructed to judge the solvability of items. In a 24-h delayed surprise memory test, participants attempted to solve previously encountered items and additionally performed a recognition memory test. During this test, older adults correctly solved an equal proportion of new CRA items compared to young adults and both age groups reported a similar frequency of Aha! experiences. While overall memory performance was better in young participants (higher proportion of correctly solved and correctly recognized old CRA items), older participants exhibited a stronger beneficial effect of insight-like sudden comprehension on later recognition memory for CRA items. Our results suggest that learning via insight might constitute a promising approach to improve memory function in old age.
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When we are confronted with a new problem, we typically try to apply strategies that have worked in the past and which usually lead closer to the solution incrementally. However, sometimes, either during a problem-solving attempt that does not seem to lead closer to the solution, or when we have given up on problem-solving for the moment, the solution seems to appear out of nowhere. This is often called a moment of insight. Whereas the cognitive processes of getting closer to the solution are still unknown for insight problem-solving, there are two diverging theories on the subjective feeling of getting closer to the solution: (1) One that states that an intuitive feeling of closeness to the solution increases slowly, but incrementally, before it surpasses the threshold to consciousness and becomes verbalizable (=insight) (continuous approach), and (2) another that proposes that the feeling of closeness to the solution does not increase before it exceeds the threshold to consciousness (discontinuous approach). Here, we investigated the subjective feeling of closeness to the solution, assessed as feeling-of-warmth (FoW), its relationship to solving the problem versus being presented with it and whether a feeling of Aha! was experienced. Additionally, we tested whether Aha! experiences are more likely when the problem is solved actively by the participant or presented to the participant after an unsuccessful problem-solving attempt, and whether the frequency of Aha! experiences correlates with problem difficulty. To our knowledge, this is the first study combining the CRAT with FoW assessments for the named conditions (solved/unsolved, three difficulty levels, Aha!/no Aha!). We used a verbal problem-solving task, the Compound Remote Associates Task (CRAT). Our data revealed that Aha! experiences were more often reported for solutions generated by the participant compared to solutions presented after unsuccessful problem-solving. Moreover, FoW curves showed a steeper increase for the last two FoW ratings when problems were solved with Aha! in contrast to without Aha!. Based on this observation, we provide a preliminary explanation for the underlying cognitive process of solving CRA problems via insight.