Detalhe da pesquisa
1.
On- and off-target effects of paired CRISPR-Cas nickase in primary human cells.
Mol Ther;
32(5): 1298-1310, 2024 May 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38459694
2.
A novel Cas9 fusion protein promotes targeted genome editing with reduced mutational burden in primary human cells.
Nucleic Acids Res;
51(9): 4660-4673, 2023 05 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37070192
3.
Prediction and validation of hematopoietic stem and progenitor cell off-target editing in transplanted rhesus macaques.
Mol Ther;
30(1): 209-222, 2022 01 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34174439
4.
Transient inhibition of 53BP1 increases the frequency of targeted integration in human hematopoietic stem and progenitor cells.
Nat Commun;
15(1): 111, 2024 Jan 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38169468
5.
Efficient and safe therapeutic use of paired Cas9-nickases for primary hyperoxaluria type 1.
EMBO Mol Med;
16(1): 112-131, 2024 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38182795
6.
Clinical genome editing to treat sickle cell disease-A brief update.
Front Med (Lausanne);
9: 1065377, 2022.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36698803
7.
Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq.
Cell Stem Cell;
28(6): 1136-1147.e5, 2021 06 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33626327
8.
Checkpoint adaptation in recombination-deficient cells drives aneuploidy and resistance to genotoxic agents.
DNA Repair (Amst);
95: 102939, 2020 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32777450
9.
A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition.
Aging (Albany NY);
7(11): 911-27, 2015 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26546739
10.
High nutrient levels and TORC1 activity reduce cell viability following prolonged telomere dysfunction and cell cycle arrest.
Cell Rep;
9(1): 324-335, 2014 Oct 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25263563
11.
Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence.
Nat Struct Mol Biol;
20(10): 1199-205, 2013 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24013207