Detalhe da pesquisa
1.
Identification and characterisation of carnostatine (SAN9812), a potent and selective carnosinase (CN1) inhibitor with in vivo activity.
Amino Acids;
51(1): 7-16, 2019 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29922921
2.
Mechanistic investigations of the liver toxicity of the free fatty acid receptor 1 agonist fasiglifam (TAK875) and its primary metabolites.
J Biochem Mol Toxicol;
33(8): e22345, 2019 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31066974
3.
Benzimidazole-carboxamides as potent and bioavailable stearoyl-CoA desaturase (SCD1) inhibitors from ligand-based virtual screening and chemical optimization.
Bioorg Med Chem Lett;
23(6): 1817-22, 2013 Mar 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23395660
4.
Additive efficacy of a bispecific anti-TNF/IL-6 nanobody compound in translational models of rheumatoid arthritis.
Sci Transl Med;
15(681): eabq4419, 2023 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36724239
5.
An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis.
Front Pharmacol;
13: 1037983, 2022.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36467083
6.
Differential epitope identification of antibodies against intracellular domains of alzheimer's amyloid precursor protein using high resolution affinity-mass spectrometry.
Subcell Biochem;
43: 339-54, 2007.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17953402
7.
Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa).
J Med Chem;
59(20): 9567-9573, 2016 Oct 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27749053
8.
Identification and structural characterisation of carboxy-terminal polypeptides and antibody epitopes of Alzheimer's amyloid precursor protein using high-resolution mass spectrometry.
Eur J Mass Spectrom (Chichester);
11(5): 547-56, 2005.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16322661
9.
Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) from Natural Product Anabaenopeptin.
J Med Chem;
58(11): 4839-44, 2015 Jun 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25990761
10.
End-organ protection in hypertension by the novel and selective Rho-kinase inhibitor, SAR407899.
World J Cardiol;
7(1): 31-42, 2015 Jan 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25632317
11.
In vivo visualization of osteoarthritic hypertrophic lesions.
Chem Sci;
6(11): 6256-6261, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30090244
12.
Antibiotics. Targeting DnaN for tuberculosis therapy using novel griselimycins.
Science;
348(6239): 1106-12, 2015 Jun 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26045430
13.
Small Macrocycles As Highly Active Integrin α2ß1 Antagonists.
ACS Med Chem Lett;
5(2): 193-8, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24900800
14.
Discovery and pharmacological characterization of SAR707 as novel and selective small molecule inhibitor of stearoyl-CoA desaturase (SCD1).
Eur J Pharmacol;
707(1-3): 140-6, 2013 May 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23524088
15.
Identification of high-affinity P2Y12 antagonists based on a phenylpyrazole glutamic acid piperazine backbone.
J Med Chem;
55(20): 8615-29, 2012 Oct 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22984835
16.
Novel ß-amino acid derivatives as inhibitors of cathepsin A.
J Med Chem;
55(17): 7636-49, 2012 Sep 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22861813
17.
Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor.
Hypertension;
54(3): 676-83, 2009 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19597037
18.
"Affinity-proteomics": direct protein identification from biological material using mass spectrometric epitope mapping.
Anal Bioanal Chem;
378(4): 1102-11, 2004 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12955276