Brain-Periphery Interactions in Huntington's Disease: Mediators and Lifestyle Interventions.

Prominent pathological features of Huntington's disease (HD) are aggregations of mutated Huntingtin protein (mHtt) in the brain and neurodegeneration, which causes characteristic motor (such as chorea and dystonia) and non-motor symptoms. However, the numerous systemic and peripheral deficits in HD have gained increasing attention recently, since those factors likely modulate disease progression, including brain pathology. While whole-body metabolic abnormalities and organ-specific pathologies in HD have been relatively well described, the potential mediators of compromised inter-organ communication in HD have been insufficiently characterized. Therefore, we applied an exploratory literature search to identify such mediators. Unsurprisingly, dysregulation of inflammatory factors, circulating mHtt, and many other messenger molecules (hormones, lipids, RNAs) were found that suggest impaired inter-organ communication, including of the gut-brain and muscle-brain axis. Based on these findings, we aimed to assess the risks and potentials of lifestyle interventions that are thought to improve communication across these axes: dietary strategies and exercise. We conclude that appropriate lifestyle interventions have great potential to reduce symptoms and potentially modify disease progression (possibly via improving inter-organ signaling) in HD. However, impaired systemic metabolism and peripheral symptoms warrant particular care in the design of dietary and exercise programs for people with HD.

Hypoxia Sensing and Responses in Parkinson's Disease.

Parkinson's disease (PD) is associated with various deficits in sensing and responding to reductions in oxygen availability (hypoxia). Here we summarize the evidence pointing to a central role of hypoxia in PD, discuss the relation of hypoxia and oxygen dependence with pathological hallmarks of PD, including mitochondrial dysfunction, dopaminergic vulnerability, and alpha-synuclein-related pathology, and highlight the link with cellular and systemic oxygen sensing. We describe cases suggesting that hypoxia may trigger Parkinsonian symptoms but also emphasize that the endogenous systems that protect from hypoxia can be harnessed to protect from PD. Finally, we provide examples of preclinical and clinical research substantiating this potential.

A case-control study on physical activity preferences, motives, and barriers in patients with psychiatric conditions.

BACKGROUND: Physical activity in individuals diagnosed with psychiatric conditions (patients) has antidepressant and anxiolytic effects, but levels of physical activity are still low in this population. This study aimed to identify physical activity preferences, motives, and perceived barriers in patients compared to individuals without a diagnosed psychiatric condition (controls). METHODS: A total of 230 patients (age = 39.5 ± 14.0 years, 80% female) with major depression (34%), anxiety disorders (38%), or post-traumatic stress disorder (28%) completed a cross-sectional online survey to assess preferences, motives, and perceived barriers to physical activity (measured by the EMI-2). This group consisted of 100 patients with a clinical diagnosis (clinical subset) and 130 with self-reported psychiatric conditions (confirmed by the PHQ-4) from online help forums (online subset). Comparisons between patients of the clinical and the online subsets were performed and are referenced whenever significant. The patients group was compared to a healthy control group matched by sex and age (n = 230, age = 39.4 ± 14.9 years, 80% female). RESULTS: More patients reported insufficient physical activity levels and more daily sitting hours (measured by the IPAQ) compared to controls. Patients reported lower preference in more ambitious types of physical activity, such as hiking, cycling, and running. The commonly most preferred type of physical activity in both groups was walking and yoga. Patients had fewer motives and more perceived barriers to physical activity in comparison to the control group. Some differences in motives and perceived barriers to physical activity were also found between patients of the clinical and the online subset. CONCLUSIONS: Findings of low physical activity levels in patients are consistent with the literature. Due to the patients' lack of motivation and perception of barriers, health care providers should consider offering different and individualized forms of physical activity. Easier types of physical activity, such as walking and yoga, appear to be the most feasible and provide a good starting point to overcome perceived barriers to physical activity.

[Risk-taking Behaviour and Aspects on Adolescents' Participation in High-risk Sports]. / Risikoverhalten und Aspekte der Risikosportpartizipation im Jugendalter.

Risk-taking Behaviour and Aspects on Adolescents' Participation in High-risk Sports The age of adolescence represents an enhanced reward sensitivity which is often linked to increased risk-taking behaviour. Peers enhance risk-taking behaviour which is shown through delinquency and substance use. Whereas most research on adolescent risk-taking has been directed towards negative risk-taking, this narrative review tries to highlight adventure and high-risk sport participation as a prosocial form of risk-taking and its potential influence on adolescents' behaviour. Adventure/high-risk sports such as mountainbiking, freeride ski and snowboarding and climbing have grown exponentially in the last years with a high popularity among adolescents. Besides the inherent risk of severe injury in case of a mismanaged accident, which should be minimized by preventive steps such as educative risk-management and protective gear, those sports bear the potential for multiple psychological benefits such as enhanced mood, autonomy, resilience and self-efficacy. Adventure/high-risk sports seem to have the possibility to satisfy the need for rewards, prestige and risk-taking in a socially accepted way. Few research projects have already successfully integrated adventure sport interventions in clinical settings in mental health treatment. The idea of testing adventure/high-risk sport interventions as an addition to the treatment in child and adolescent psychiatry and psychotherapy could be promising and an impulse for future research projects.

Does Age Matter? A Qualitative Comparison of Motives and Aspects of Risk in Adolescent and Adult Freeriders.

Recent research has shown multiple motives for high-risk sport participation derived from research on adult participants. The aim of this study was to provide insights into motives and risk-related aspects in adolescent high-risk sport participants and to compare those findings with adults performing the same activity. Semi-structured interviews were conducted with 24 adolescent (14-20 years) freeriders (skiers/snowboarders who ski outside the protected areas of a ski resort) and 24 adult freeriders (26-41 years). A content analyses was done using MAXQDA software. Both cohorts reported the motives Challenge (adolescents: 92%, adults: 88%), Freedom/Pleasure (adolescents: 88%, adults: 75%), Friends (adolescents: 88%, adults: 79%) and Balance (adolescents: 63%, adults: 63%). However, the description of friends differed between adults and adolescents. Whereas adolescents mostly referred to a community and shared interests, adults described the importance of trust and the development of deep friendships through the activity more often. Nature was a major motive in adults (83%) but not in adolescents (29%). Most of the adults have already experienced a major accident or close call (n = 19; 79%), contrary to adolescents (n = 7; 29%). Adolescents learned about the risks in freeriding primarily through their families (n = 10) and the ski club (n = 9). Some adults reported to have realized the risks involved in freeriding after starting with the activity due to experienced negative outcomes. Both cohorts were largely motivated by the same motives. As the new generation of freeriders seems to receive more instructions about risk reduction, it might be interesting to see if this educational approach results into less accidents or close calls in this group.

Is the Effect of Physical Activity on Quality of Life in Older Adults Mediated by Social Support?

Increasing evidence suggests positive associations between physical activity, social support, and quality of life in later life. However, the role of physical activity and social support in the influence on quality of life is unclear. In this viewpoint, definitions of central terms and key research findings on factors influencing quality of life in older adults are provided. We highlight the importance of both a physically active lifestyle and high social support in positively influencing quality of life. However, we question the direct effect of physical activity on quality of life and present data of a cross-sectional study to support the assumption that the effect of physical activity on quality of life might be influenced by perceived social support. In this cross-sectional study, self-reported physical activity, social support, and quality of life were assessed in a nonclinical sample of 100 adults aged between 60 and 80 years. Statistical analyses included correlation analyses and covariate-controlled mediation analyses. The results confirmed the research findings on positive correlations between all domains of quality of life and both physical activity and social support. Mediation analyses indicated that the effect of physical activity on all domains of quality of life was at least partially mediated by social support, when controlled for covariates. Based on the findings of published evidence and this cross-sectional study, a socially and physically active lifestyle is recommended for older adults to positively influence quality of life. However, the well-documented effect of physical activity on quality of might be an at least partially mediated effect by perceived social support. Practical and research-related implications of a potential indirect effect are discussed. Further prospective research is warranted to clarify the relationship between the variables.

Long-term effect of migration background on the development of physical fitness among primary school children.

BACKGROUND: Children with a low socioeconomic status and migration background are more likely to exhibit unfavorable health behavior patterns and higher BMI scores as well as lower physical activity and physical fitness. AIM: To evaluate the effect of migration background on the development of physical fitness among primary school children from first to third grade. METHODS: In this longitudinal study, height, weight, and physical fitness of primary school children from Tyrol/Austria were measured five times over a period of 2.5 years using the German motor performance test DMT 6-18 consisting of eight items testing different subdomains of physical fitness. RESULTS: A total of 266 children (45% girls) participated in all five tests, of which 69 (26%) children reported to have a migration background (MB). Mixed-model ANOVA did not reveal a significantly different development of physical fitness (according to the mean total Z-score of DMT 6-18) over time, P = 0.883, partial ƞ2  < 0.01. However, children with MB showed significantly lower physical fitness compared to children without MB, P < 0.001, partial ƞ2  = 0.06. Controlling for BMI and age did not alter the interpretation of the results. Analyses of the single test items revealed significant differences in motor tests involving strength and endurance. CONCLUSION: Primary school children with and without MB significantly increased their physical fitness over time in a comparable manner. However, children with MB showed a significantly lower physical fitness at all test time points, which was only partly explained by a higher mean BMI in children with MB. Children with MB outreached the mean baseline fitness level of children without MB not until the fourth test time point, that is after two years. Therefore, a special focus on physical fitness particularly including strength and endurance capacities should be directed to children with MB already in young ages.

Alcohol Consumption and Physical Activity in Austrian College Students-A Cross-Sectional Study.

BACKGROUND: The age of college students is considered as crucial for developing health-related behaviors, e.g., alcohol consumption or a physically active lifestyle. Previous research reported a positive relationship between alcohol consumption and physical activity (PA) in college students. However, the main body of research was done in students from the United States who might differ from European students. OBJECTIVES: Thus the aim of this study was to analyze the relationship between alcohol consumption and PA in a sample of Austrian college students. METHODS: In a cross-sectional design, 861 Austrian students from various study fields responded to a web-based questionnaire. Self-reported alcohol consumption, PA, and relevant sociodemographic variables were assessed. Multiple regression analyses were used to study the relationship between alcohol consumption and PA. RESULTS: In none of the regression models, a significant relationship between alcohol consumption and PA was found. There was a significant influence of sex, age, relationship status, education level, and study field on alcohol consumption. Male, older, and undergraduate students studying social sciences without a relationship reported higher alcohol consumption. Conclusions/Importance: The results do not support a general relationship between alcohol consumption and PA among urban Austrian college students of various study fields. Compared to other variables (e.g., sex, relationship status), PA seems to be less important in relation to the consumption of alcohol. This study challenges a global perspective on a positive relationship between alcohol consumption and PA and highlights the need for more cross-cultural investigations.

Normobaric hypoxia overnight impairs cognitive reaction time.

BACKGROUND: Impaired reaction time in patients suffering from hypoxia during sleep, caused by sleep breathing disorders, is a well-described phenomenon. High altitude sleep is known to induce periodic breathing with central apneas and oxygen desaturations, even in perfectly healthy subjects. However, deficits in reaction time in mountaineers or workers after just some nights of hypoxia exposure are not sufficiently explored. Therefore, we aimed to investigate the impact of sleep in a normobaric hypoxic environment on reaction time divided by its cognitive and motoric components. Eleven healthy non acclimatized students (5f, 6m, 21 ± 2.1 years) slept one night at a simulated altitude of 3500 m in a normobaric hypoxic room, followed by a night with polysomnography at simulated 5500 m. Preexisting sleep disorders were excluded via BERLIN questionnaire. All subjects performed a choice reaction test (SCHUHFRIED RT, S3) at 450 m and directly after the nights at simulated 3500 and 5500 m. RESULTS: We found a significant increase of cognitive reaction time with higher altitude (p = 0.026). No changes were detected in movement time (p = n.s.). Reaction time, the combined parameter of cognitive- and motoric reaction time, didn't change either (p = n.s.). Lower SpO2 surprisingly correlated significantly with shorter cognitive reaction time (r = 0.78, p = 0.004). Sleep stage distribution and arousals at 5500 m didn't correlate with reaction time, cognitive reaction time or movement time. CONCLUSION: Sleep in hypoxia does not seem to affect reaction time to simple tasks. The component of cognitive reaction time is increasingly delayed whereas motoric reaction time seems not to be affected. Low SpO2 and arousals are not related to increased cognitive reaction time therefore the causality remains unclear. The fact of increased cognitive reaction time after sleep in hypoxia, considering high altitude workers and mountaineering operations with overnight stays, should be further investigated.

Influence of structural integration and fascial fitness on body image and the perception of back pain.

[Purpose] The aim of this study was to examine the influence of Structural Integration and Fascial Fitness, a new form of physical exercise, on body image and the perception of back pain. [Subjects and Methods] In total, 33 participants with non-specific back pain were split into two groups and performed three sessions of Structural Integration or Fascial Fitness within a 3-week period. Before and after the interventions, perception of back pain and body image were evaluated using standardized questionnaires. [Results] Structural Integration significantly decreased non-specified back pain and improved both "negative body image" and "vital body dynamics". Fascial Fitness led to a significant improvement on the "negative body image" subscale. Benefits of Structural Integration did not significantly vary in magnitude from those for fascial fitness. [Conclusion] Both Structural Integration and Fascial Fitness can lead to a more positive body image after only three sessions. Moreover, the therapeutic technique of Structural Integration can reduce back pain.

Differences in Sensation Seeking Between Alpine Skiers, Snowboarders and Ski Tourers.

Despite different injury rates and injury patterns previous personality related research in the field of downhill winter sports did not subdivide between different alpine slope users. In this study, we tried to find out whether the personality trait sensation seeking differs between skiers, snowboarders and ski tourers. In a cross-sectional survey 1185 persons (726 alpine skiers, 321 snowboarders and 138 ski tourers comparable in age and sex) were electronically questioned with the sensation seeking scale (SSS-V) comprising the four factors thrill and adventure seeking, experiences seeking, disinhibition and boredom susceptibility. Kruskal-Wallis Tests revealed a significantly higher total score of the SSS-V for snowboarders in comparison to alpine skiers and ski tourers (H(2) = 41.5, p < 0.001). Ski tourers and snowboarders scored significantly higher in the dimensions "thrill- and adventure-seeking" and "experience-seeking" than alpine skiers. Furthermore, snowboarders showed higher scores in "disinhibition" related to alpine skiers and ski tourers and "boredom susceptibility" compared to alpine skiers. Data show differences in the personality trait sensation seeking in people practising different winter sports. As snowboarders showed higher SS-scores compared to alpine skiers and ski tourers prevention and information programs might benefit from a selective approach focusing on special characteristics of the respective group. Key pointsIt is the very first research trying to identify differences between different types of winter sport slope usersObtained results show higher sensation seeking scores in snowboardersThese results might stimulate new approaches in educational campaigns to reduce accident rates in winter sports.

Is There a Link Between Physical Activity and Alcohol use?

Physical activity (PA) is discussed as a protective factor as well as a risk factor for alcohol consumption. Therefore, this study aimed at exploring a potential relationship between these behaviors. In a population-based cross-sectional study of 15,474 people living in Austria physical activity, alcohol consumption and demographic variables were assessed. Regression analysis including age and gender revealed no significant relationship between PA and alcohol consumption for the total sample. More alcohol consumption was found in men with low PA-levels. Focusing on a part of the population who consumed alcohol the weekend before, men with high PA-levels reported more alcohol consumption in comparison to men with moderate PA-levels. This study does not support a common alcohol-physical activity relationship. Prevention programs to increase PA levels from low to moderate combined with a reduction of alcohol intake in men who regularly drink alcohol should be considered.

A study on acute expectation effects on affective state and intention after a brief full-body workout in a student sample.

Brief exercise bouts can have positive effects on the affective state, which in turn could affect the intention for future exercise. Such benefits may be enhanced by manipulating expectations. The aim of this study was to examine whether the affective state after physical activity or the intention for future exercise can be influenced by manipulating expectations. Furthermore, the relationship between affect and intention was investigated. In an online experiment, 121 persons completed either a 10-minute workout (PA), a workout after manipulation of expectations (PA + EM), or a control intervention (CG) after randomized group allocation. Data on affective state, expectations, and intention were collected before and after the intervention using questionnaires. After intervention, PA groups showed significantly more positive values than CG in several affective parameters, in other affective parameters, only PA + EM differed from CG. Affect was positively associated with intention alongside outcome expectations. No difference was found in intention. Although no significant effects of expectation manipulation on affective state or intention were found, latent effects cannot be ruled out. Further exploration of the importance of word choice in describing physical activity in the context of interventions to increase physical activity is necessary. Here, affect should be considered.

Validity, reliability, and invariance across sex of a German version of the Behavioral Regulation in Exercise Questionnaire.

Objective: Since there is no scientifically validated German version of the Behavioral Regulation in Exercise Questionnaire (BREQ-3), the aim of this study was to assess its psychometric parameters and invariance across sex in a sample of German-speaking young adults. The BREQ-3 is an instrument measuring the social and internal influences of motivation toward exercising. This tool is widespread within the scientific community and has been validated in several languages. Methods: A total of 271 participants (45% women; mean age = 20.67 ± 2.17 years; effect size ≥ 0.5) filled in the BREQ-3 at one time point, with a small sub-sample (n = 37) responding it a second time after 15 days. Confirmatory Factorial Analysis, Structural Modeling, and Intraclass Correlation Coefficient were used to examine the German version of the questionnaire. Results: Results highlighted a good fit of the six-dimensional model after the removal of two items (CFI = 0.912; SRMR = 0.0594; RMSEA = 0.064), as well as full invariance across sex (pχ2 = 0.218; ΔCFI < 0.01). Internal consistency and reliability were moderate to good. Conclusions: The 22-item German BREQ-3 is a scientifically valid instrument that can be used in cross-national studies dealing with social aspects of exercise behaviors.

Acute effects of outdoor and indoor walking on cigarette cravings, withdrawal symptoms and affective response during temporary smoking abstinence.

RATIONALE: Cigarette smoking is one of the leading preventable causes of premature death worldwide. There is evidence in the literature that brief exercise units indoors can improve well-being in temporarily abstinent smokers and reduce cigarette cravings and withdrawal symptoms. OBJECTIVE: Because exercise in natural environments showed enhanced psychological effects, the aim of our study was to examine the acute effects of outdoor exercise compared with indoor exercise on craving, withdrawal symptoms and affective response in temporarily abstinent smokers. METHODS: In a randomized controlled within-subject-design, temporarily abstinent smokers (N = 16) participated in three interventions lasting 10 min: outdoor walking (OUT-EX), indoor walking (IN-EX) and a sedentary control condition (CC). Self-reported cigarette craving, withdrawal symptoms and affective response were assessed pre-, mid-, post-interventions and at follow-up. RESULTS: In contrast to CC, OUT-EX and IN-EX significantly reduced cigarette cravings during and at the end of the intervention compared to pre-intervention, but not at 20 min follow-up. Cigarette withdrawal symptoms decreased significantly over time in all three groups, but no significant group differences were found. OUT-EX and IN-EX, but not CC, showed significantly improved affective valence at the end of the intervention and at follow-ups. Outdoor walking resulted in significantly lower cigarette cravings than indoor walking at the end of the intervention. CONCLUSION: The study adds to existing evidence that short bouts of indoor or outdoor exercise can help reduce cigarette cravings and increase well-being in abstinent smokers. Further studies are needed to address the potential additional effect of outdoor exercise on craving, affective states and smoking cessation.

Life-style characteristics and cardiovascular risk factors in regular downhill skiers: an observational study.

BACKGROUND: Downhill skiing is part of active life style in many residents of Alpine regions. However, only very little information is available whether downhill skiing on a regular basis is associated with a healthier life style resulting in the reduction of major risk factors for cardiovascular diseases and memory deficits when compared to the general population. Thus, the aim of the study was to compare life-style characteristics and cardiovascular risk factors between regular downhill skiers and the general population. METHODS: Self-reported health and life-style data were collected by questionnaire from 1259 long-term downhill skiers (971 males, aged 57.3 ± 14.6 years; 288 females, aged 47.7 ± 16.4 years) and compared with data from the general population. RESULTS: Long-term skiers showed more favourable life-style characteristics and a better health status than the general population. Prevalences of hypercholesterolemia, systemic hypertension, diabetes, the frequency of mental stress and the occurrence of memory deficits declined with increasing yearly skiing frequency. CONCLUSION: Long-term alpine skiing on a regular basis may contribute to healthy aging by its association with a healthier life style.

Injuries in judo: a systematic literature review including suggestions for prevention.

BACKGROUND: There is limited knowledge on epidemiological injury data in judo. OBJECTIVE: To systematically review scientific literature on the frequency and characteristics of injuries in judo. METHODS: The available literature up to June 2013 was searched for prospective as well as retrospective studies on injuries in judo. Data extraction and presentation focused on the incidence rate, injury risk, types, location and causes of injuries. RESULTS: During the Olympic Games in 2008 and 2012, an average injury risk of about 11-12% has been observed. Sprains, strains and contusions, usually of the knee, shoulder and fingers, were the most frequently reported injuries, whereas being thrown was the most common injury mechanism. Severe injuries were quite rare and usually affected the brain and spine, whereas chronic injuries typically affected the finger joints, lower back and ears. The most common types of injuries in young judo athletes were contusions/abrasions, fractures and sprains/strains. Sex-differences data on judo injuries were mostly inconsistent. Some studies suggested a relationship between nutrition, hydration and/or weight cycling and judo injuries. Also, psychological factors may increase the risk of judo injuries. CONCLUSIONS: The present review provides the latest knowledge on the frequency and characteristics of injuries in judo. Comprehensive knowledge about the risk of injury during sport activity and related risk factors represents an essential basis to develop effective strategies for injury prevention. Thus, the introduction of an ongoing injury surveillance system in judo is of utmost importance.

Factors associated with the ability to estimate actual speeds in recreational alpine skiers.

OBJECTIVE: To measure on-slope speeds of alpine skiers and to compare their ability to accurately estimate their actual speed with regard to measured speed, age, sex, skill level, helmet use, and risk-taking behavior. METHODS: Skiing speeds of 416 adult skiers (62% men, 38% women) were measured with a radar speed gun. Skiers were interviewed about their age, sex, skiing ability, helmet use, and risk-taking behavior. Additionally, skiers had to estimate their measured speed as accurately as possible. The difference between estimated and measured speed was described as error of estimation (EE). RESULTS: Mean measured speed (±SD) of all participants was 48.2 (±14.3) km/h. Pearson correlation coefficient between the actual speed and the estimated speed was 0.57 (P < .001) for all participants. Skiers underestimated their measured speed on average by 5.8 km/h or 8.1%. A multiple hierarchical linear regression analysis revealed that when skiing speed is increased by 1 km/h the EE significantly decreases by 0.5 km/h. Male sex, higher skill level, risky skiing behavior, and younger age groups showed a significantly better ability to estimate skiing speed, whereas ski helmet use did not. CONCLUSIONS: Skiing speed, age, sex, skill level, and risk-taking behavior seem to influence the ability to estimate actual speeds in recreational alpine skiers.

[Patterns of dysfunctional parenting styles and psychological disturbances in offspring]. / Muster dysfunktionaler Erziehungsstile und psychische Storungen im Erwachsenenalter.

OBJECTIVES: Dysfunctional parenting styles represent a risk factor for the development of psychological disturbances. The present study investigated the differential validity of the German language Fragebogen zur Erfassung dysfunktionaler Erziehungsstile (FDEB; Measurement of Parental Styles, MOPS) and determined whether different forms of psychological disorders are associated with specific patterns of parenting styles. METHODS: 145 inpatients, 108 outpatients and a control group of 633 representative individuals from the general population were investigated by adapting the FDEB. RESULTS: A comparison of dysfunctional parenting styles showed different distress levels within the diagnostic groups: Patients suffering from depression reported high levels of maternal indifference and over protectiveness together with an abusive rearing behavior on the part of both parents. Patients with anxiety disorders reported having overprotective mothers. Bulimic patients as well as those with personality disorders significantly exhibited stress in almost all areas. However, anorexic patients did not differ significantly from the control group, which appeared to be the least affected of all. CONCLUSION: The FDEB showed a satisfactory differential validity. There was evidence that specific patterns of dysfunctional parenting styles were associated with different diagnostic groups.