Detalhe da pesquisa
1.
Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development.
Blood;
143(12): 1167-1180, 2024 Mar 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38142429
2.
FcRn augments induction of tissue factor activity by IgG-containing immune complexes.
Blood;
135(23): 2085-2093, 2020 06 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32187355
3.
Exosite binding drives substrate affinity for the activation of coagulation factor X by the intrinsic Xase complex.
J Biol Chem;
295(45): 15198-15207, 2020 11 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32859749
4.
Occlusion of anion-binding exosite 2 in meizothrombin explains its impaired ability to activate factor V.
J Biol Chem;
294(7): 2422-2435, 2019 02 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30578302
5.
Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex.
Blood;
130(14): 1661-1670, 2017 10 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28729433
6.
The Fragment 1 Region of Prothrombin Facilitates the Favored Binding of Fragment 12 to Zymogen and Enforces Zymogen-like Character in the Proteinase.
J Biol Chem;
291(21): 11114-23, 2016 May 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27013660
7.
FVIII-VWF dos-à-dos.
Blood;
126(8): 923-4, 2015 Aug 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26294711
8.
New insights into the spatiotemporal localization of prothrombinase in vivo.
Blood;
124(11): 1705-14, 2014 Sep 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24869936
9.
Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis.
Blood;
122(16): 2777-83, 2013 Oct 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23869089
10.
Modulation of protein C activation by histones, platelet factor 4, and heparinoids: new insights into activated protein C formation.
Arterioscler Thromb Vasc Biol;
34(1): 120-6, 2014 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24177324
11.
Membrane binding by prothrombin mediates its constrained presentation to prothrombinase for cleavage.
J Biol Chem;
288(39): 27789-800, 2013 Sep 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23940050
12.
Restoring the procofactor state of factor Va-like variants by complementation with B-domain peptides.
J Biol Chem;
288(42): 30151-30160, 2013 Oct 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24014022
13.
Aptameric hirudins as selective and reversible EXosite-ACTive site (EXACT) inhibitors.
Nat Commun;
15(1): 3977, 2024 May 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38730234
14.
Meizothrombin is an unexpectedly zymogen-like variant of thrombin.
J Biol Chem;
287(36): 30414-25, 2012 Aug 31.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22815477
15.
Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT.
Blood;
118(10): 2882-8, 2011 Sep 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21772054
16.
Individual phosphatidylinositol transfer proteins have distinct functions that do not involve lipid transfer activity.
Blood Adv;
7(16): 4233-4246, 2023 08 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36930803
17.
Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo.
J Biol Chem;
286(26): 23345-56, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21531712
18.
Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples.
Cell Chem Biol;
29(2): 215-225.e5, 2022 02 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35114109
19.
Regulated cleavage of prothrombin by prothrombinase: repositioning a cleavage site reveals the unique kinetic behavior of the action of prothrombinase on its compound substrate.
J Biol Chem;
285(1): 328-38, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19858193
20.
Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states.
J Biol Chem;
285(37): 28651-8, 2010 Sep 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20639195