1.
J Org Chem
; 74(11): 4068-79, 2009 Jun 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19391593
RESUMO
BMS-317180 (1) is a potent, orally active agonist of the human growth hormone secretagogue (GHS) receptor. This manuscript details the process research and development efforts that enabled the synthesis of the phosphate salt of 1 on a multi-kilogram scale. Key considerations in the development of this process focused on safe execution and the requirement for telescoped synthetic transformations (i.e., without isolation of intermediate products) to contend with a lack of suitably crystalline products.