Detalhe da pesquisa
1.
Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.
Mol Cell;
72(1): 178-186.e5, 2018 10 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30270109
2.
Utilization of diverse organophosphorus pollutants by marine bacteria.
Proc Natl Acad Sci U S A;
119(32): e2203604119, 2022 08 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35917352
3.
Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro.
Arch Toxicol;
90(11): 2711-2724, 2016 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26612364
4.
Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.
Nat Chem Biol;
8(3): 294-300, 2012 Feb 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22306579
5.
Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro.
Arch Toxicol;
88(6): 1257-66, 2014 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24477626
6.
Directed evolution of hydrolases for prevention of G-type nerve agent intoxication.
Nat Chem Biol;
7(2): 120-5, 2011 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21217689
7.
The impact of molecular variants, crystallization conditions and the space group on ligand-protein complexes: a case study on bacterial phosphotriesterase.
Acta Crystallogr D Struct Biol;
79(Pt 11): 992-1009, 2023 Nov 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37860961
8.
Versatile scheme for the step-by-step assembly of nanoparticle multilayers.
Langmuir;
27(4): 1298-307, 2011 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21254761
9.
Rapid formation of coordination multilayers using accelerated self-assembly procedure (ASAP).
Langmuir;
26(10): 7277-84, 2010 May 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20163094
10.
A mixture of three engineered phosphotriesterases enables rapid detoxification of the entire spectrum of known threat nerve agents.
Protein Eng Des Sel;
32(4): 169-174, 2019 12 31.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31612205
11.
Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers.
Protein Eng Des Sel;
30(4): 333-345, 2017 04 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28159998
12.
In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications.
Chem Biol Interact;
259(Pt B): 252-256, 2016 Nov 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27163850
13.
Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors.
J Med Chem;
45(4): 902-10, 2002 Feb 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11831902
14.
Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators.
Biochem Pharmacol;
66(2): 191-202, 2003 Jul 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12826262
15.
Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase.
Biochem Pharmacol;
66(3): 387-92, 2003 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12907237
16.
Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: a proof-of-concept study.
Toxicol Lett;
231(1): 45-54, 2014 Nov 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25195526
17.
Engineering V-type nerve agents detoxifying enzymes using computationally focused libraries.
ACS Chem Biol;
8(11): 2394-403, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24041203
18.
Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification.
Chem Biol;
19(4): 456-66, 2012 Apr 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22520752
19.
In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases.
Toxicol Lett;
206(1): 24-8, 2011 Sep 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21807078
20.
Pro-2-PAM therapy for central and peripheral cholinesterases.
Chem Biol Interact;
187(1-3): 191-8, 2010 Sep 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20156430