Detalhe da pesquisa
1.
A phase I window, dose escalating and safety trial of metformin in combination with induction chemotherapy in relapsed refractory acute lymphoblastic leukemia: Metformin with induction chemotherapy of vincristine, dexamethasone, PEG-asparaginase, and doxorubicin.
Pediatr Blood Cancer;
65(9): e27224, 2018 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29856514
2.
Immunotherapeutic approach to reduce senescent cells and alleviate senescence-associated secretory phenotype in mice.
Aging Cell;
22(5): e13806, 2023 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36967480
3.
A Fusion Protein Complex that Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer Immunotherapy.
Cancer Immunol Res;
9(9): 1071-1087, 2021 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34244297
4.
Specific GATA-binding elements in the GnRH promoter are required for gene expression pulse activity: role of GATA-4 and GATA-5 in this intermittent process.
Neuroendocrinology;
88(1): 1-16, 2008.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18259093
5.
Inhibition of the NEDD8 conjugation pathway induces calcium-dependent compensatory activation of the pro-survival MEK/ERK pathway in acute lymphoblastic leukemia.
Oncotarget;
9(5): 5529-5544, 2018 Jan 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29464016
6.
Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy.
Mol Cancer;
6: 46, 2007 Jul 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17623090
7.
Calcium influx and DREAM protein are required for GnRH gene expression pulse activity.
Mol Cell Endocrinol;
267(1-2): 70-9, 2007 Mar 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17241740
8.
Analysis of folylpoly-gamma-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cells.
BMC Cancer;
6: 132, 2006 May 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16707018
9.
The NEDD8-activating enzyme inhibitor pevonedistat activates the eIF2α and mTOR pathways inducing UPR-mediated cell death in acute lymphoblastic leukemia.
Leuk Res;
50: 1-10, 2016 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27626202
10.
Pulses of prolactin promoter activity depend on a noncanonical E-box that can bind the circadian proteins CLOCK and BMAL1.
Endocrinology;
146(6): 2782-90, 2005 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15774559
11.
Identification of a novel OCT1 binding site that is necessary for the elaboration of pulses of rat GnRH promoter activity.
Mol Cell Endocrinol;
245(1-2): 86-92, 2005 Dec 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16337733
12.
Episodic activation of the rat GnRH promoter: role of the homeoprotein oct-1.
Mol Endocrinol;
16(9): 2093-100, 2002 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12198245
13.
Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress.
Leuk Res;
2015 Aug 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26346348
14.
PRL gene expression in individual living mammotropes displays distinct functional pulses that oscillate in a noncircadian temporal pattern.
Endocrinology;
143(3): 1126-33, 2002 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11861540
15.
Real-time RT-PCR analysis of mRNA decay: half-life of Beta-actin mRNA in human leukemia CCRF-CEM and Nalm-6 cell lines.
Cancer Cell Int;
2(1): 1, 2002 Mar 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11988110
16.
Metformin induces apoptosis through AMPK-dependent inhibition of UPR signaling in ALL lymphoblasts.
PLoS One;
8(8): e74420, 2013.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24009772
17.
Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia.
Mol Cancer Res;
10(7): 969-78, 2012 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22692960
18.
AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia.
Mol Cancer Ther;
10(3): 437-47, 2011 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21262957
19.
Administration of connexin43 siRNA abolishes secretory pulse synchronization in GnRH clonal cell populations.
Mol Cell Endocrinol;
314(1): 75-83, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19716855
20.
AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia.
J Mol Signal;
5: 15, 2010 Sep 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20863384