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1.
ScientificWorldJournal ; 2014: 382797, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25250374

RESUMO

In mobile cloud computing environment, the cooperation of distributed computing objects is one of the most important requirements for providing successful cloud services. To satisfy this requirement, all the members, who are employed in the cooperation group, need to share the knowledge for mutual understanding. Even if ontology can be the right tool for this goal, there are several issues to make a right ontology. As the cost and complexity of managing knowledge increase according to the scale of the knowledge, reducing the size of ontology is one of the critical issues. In this paper, we propose a method of extracting ontology module to increase the utility of knowledge. For the given signature, this method extracts the ontology module, which is semantically self-contained to fulfill the needs of the service, by considering the syntactic structure and semantic relation of concepts. By employing this module, instead of the original ontology, the cooperation of computing objects can be performed with less computing load and complexity. In particular, when multiple external ontologies need to be combined for more complex services, this method can be used to optimize the size of shared knowledge.


Assuntos
Sistemas Computacionais , Disseminação de Informação/métodos , Armazenamento e Recuperação da Informação/métodos , Bases de Conhecimento , Algoritmos , Biologia Computacional/métodos , Humanos
2.
J Microbiol Biotechnol ; 29(1): 21-29, 2019 Jan 28.
Artigo em Inglês | MEDLINE | ID: mdl-30609887

RESUMO

The effects of Lavandula angustifolia extract fermented with Pediococcus pentosaceus DK1 on UVB-mediated MMP-1 expression and collagen decrease in human skin fibroblasts were determined, and the conversion of its components was also analyzed. Fermentation was performed at varying L. angustifolia extract and MRS medium concentrations, and optimal fermentation conditions were selected. L. angustifolia extracts showed decreased cytotoxicity after fermentation in the fibroblasts. UVB-irradiated fibroblasts treated with fermented L. angustifolia extract showed MMP-1 expression 8.2-14.0% lower than that in UVB-irradiated fibroblasts treated with non-fermented extract. This was observed even at fermented extract concentrations lower than those of non-fermented extracts. Fibroblasts treated with fermented L. angustifolia extract showed 20% less reduction in collagen production upon UVB irradiation than those treated with non-fermented extracts. UVB-irradiated fibroblasts treated with fermented L. angustifolia extracts showed 50% higher inhibition of ROS generation than those treated with non-fermented extract. Luteolin and apigenin glycosides of L. angustifolia were converted during fermentation, and identified using RP-HPLC and LC/ESI-MS. Therefore, the effects of L. angustifolia extract on MMP-1 expression and collagen decrease in UVB-irradiated human skin fibroblasts were increased through fermentation by P. pentosaceus.


Assuntos
Diospyros/microbiologia , Lavandula/química , Pediococcus pentosaceus/metabolismo , Extratos Vegetais/metabolismo , Extratos Vegetais/farmacologia , Protetores contra Radiação/farmacologia , Envelhecimento da Pele/efeitos dos fármacos , Linhagem Celular , Colágeno Tipo I/metabolismo , Fermentação , Fibroblastos/efeitos dos fármacos , Fibroblastos/metabolismo , Fibroblastos/efeitos da radiação , Frutas/microbiologia , Expressão Gênica/efeitos dos fármacos , Expressão Gênica/efeitos da radiação , Humanos , Metaloproteinase 1 da Matriz/genética , Pró-Colágeno/metabolismo , Espécies Reativas de Oxigênio/metabolismo , Envelhecimento da Pele/genética , Envelhecimento da Pele/efeitos da radiação , Raios Ultravioleta/efeitos adversos
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