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1.
J Pediatr Orthop ; 41(6): e464-e469, 2021 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-34096552

RESUMO

BACKGROUND: Closed reduction and percutaneous pinning is the standard of care for displaced supracondylar humerus fractures (SCHFs). Although the operative management of SCHFs has achieved good consensus with low complication rates, there remains a paucity of literature on postoperative management. We hypothesized that routine office visits after pin removal can safely be avoided in uncomplicated SCHFs without compromising patient care. METHOD: A retrospective review was conducted to query the electronic medical record for SCHFs, treated with closed reduction and percutaneous pinning. Patients with complicated SCHFs were excluded. Patients were divided into 2 cohorts: follow-up (FU) and nonfollow-up (NFU), depending on the presence or absence of after-pin removal (APR) FU visits. Demographics, surgical variables, number of x-rays, referrals for physical therapy, total FU visits, complications, and clinical events after pin removal up to 3 months were compared. Subgroup analysis was performed according to Gartland fracture types. RESULTS: A total of 179 patients were included in the study, 111 in the FU group and 68 in the NFU group. There were no significant differences found in demographics between the 2 groups. There were no significant differences in complications and APR clinical events between 2 groups (P>0.05). An average of 1.98 additional x-rays were taken APR in FU group. None of the NFU group patients required physical therapy. Excluding patients with pin site infections, 15/108 (13.9%) of FU group patients had >1 APR visits. SUMMARY: For operatively managed uncomplicated SCHFs, patients who do not have routinely scheduled FU APR have no greater incidence of clinical events APR than patients with a scheduled FU. With a detailed discussion including expectations, timeframe for resuming activities, home exercises, and reassurance of the ease of FU if desired, routine FU APR can be safely eliminated after uncomplicated SCHFs in order to streamline postoperative care. LEVEL OF EVIDENCE: Level III.


Assuntos
Fraturas do Úmero/cirurgia , Cuidados Pós-Operatórios , Pinos Ortopédicos , Criança , Pré-Escolar , Exercício Físico , Feminino , Seguimentos , Fixação de Fratura/efeitos adversos , Humanos , Lactente , Masculino , Período Pós-Operatório , Radiografia , Estudos Retrospectivos
2.
J Hand Surg Am ; 37(2): 316-21, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22119603

RESUMO

The Food and Drug Administration (FDA) indicates that bone morphogenetic protein (BMP) products are contraindicated in pediatric patients. However, it acknowledges the off-label use of BMP in difficult cases. Although the relative safety of BMP in children has been reported for lower extremity and spine procedures, little information exists for the safety of BMP used in the pediatric upper extremity. We present a case of a massive inflammatory reaction after use of recombinant human BMP-2 for repair of a symptomatic ulnar nonunion in a child. The case illustrates the potential difficulties of using the dose-dependent properties of BMP in the treatment of pediatric upper extremity nonunions when the dose calculations of BMP for children have not yet been defined.


Assuntos
Proteína Morfogenética Óssea 2/efeitos adversos , Reabsorção Óssea/induzido quimicamente , Fraturas não Consolidadas/terapia , Osteíte/induzido quimicamente , Deiscência da Ferida Operatória/induzido quimicamente , Fator de Crescimento Transformador beta/efeitos adversos , Fraturas da Ulna/terapia , Criança , Fraturas não Consolidadas/patologia , Humanos , Masculino , Uso Off-Label , Proteínas Recombinantes/efeitos adversos , Fraturas da Ulna/patologia
3.
JBJS Case Connect ; 12(1)2022 01 26.
Artigo em Inglês | MEDLINE | ID: mdl-35081063

RESUMO

CASE: We report a 14-year-old girl with adolescent idiopathic scoliosis who experienced bilateral lower extremity paralysis related to postoperative hypotension 10 hours after posterior spinal fusion. She returned to the operating room for spinal cord decompression and hardware removal. Six weeks later, reinstrumentation was performed, and complete neurologic recovery was achieved. CONCLUSION: Delayed presentation of neurologic injury after scoliosis surgery is particularly uncommon. Close postoperative monitoring, with an emphasis on hypotensive etiologies and a low threshold to remove the instrumentation, is essential to rapidly diagnose and treat these catastrophic events.


Assuntos
Cifose , Escoliose , Traumatismos da Medula Espinal , Fusão Vertebral , Adolescente , Feminino , Humanos , Cifose/cirurgia , Paraplegia/etiologia , Paraplegia/cirurgia , Escoliose/complicações , Escoliose/cirurgia , Traumatismos da Medula Espinal/etiologia , Traumatismos da Medula Espinal/cirurgia , Fusão Vertebral/efeitos adversos
4.
J Am Acad Orthop Surg ; 30(15): e1025-e1032, 2022 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-35617643

RESUMO

INTRODUCTION: Although regarded as conservative treatment, casting is not without risk. Injuries may be sustained during application, during cast valving, through the immobilization process, or during cast removal. We developed an experimental model to investigate safe parameters for the appropriate length of time between fiberglass cast application and bivalving for cast saw use. METHODS: A hospital sheet was rolled into a mock "arm" on which short-arm fiberglass casts were formed. An appropriate cast saw technique was used with complete withdrawal of the saw blade from the cast material between cuts. A total of 10 casts were made for control/no vacuum (N = 5) and study/vacuum (N = 5) groups. The temperature of the saw blade was measured at 1-minute increments beginning at 3 minutes after fiberglass submersion in water. A mixed factor analysis of variance assessed differences in temperature change over time between groups with a statistical threshold of P < 0.05. RESULTS: Casts that set for 7 minutes were associated with lower blade temperatures compared with casts that set for 3, 4, 5, and 6 minutes. The average temperature increases for the 3- to 7-minute set times without the use of vacuum were 10.08 (± 1.42), 9.38 (±1.31), 9.32 (±1.85), 8.54 (±2.10), and 5.62°F (±2.42), respectively, and with the use of vacuum, they were 9.40 (±1.14), 8.36 (±1.64), 7.84 (±2.05), 7.30 (±3.14), and 4.82°F (±2.59), respectively. Independent of vacuum use, the change in temperature was significantly different from the maximum temperature (3 minutes) beginning at 7 minutes (all P < 0.043). DISCUSSION: A minimum of 7 minutes of set time for a fiberglass cast before attempting to bivalve using segmented cuts is associated with the smallest increase in temperature of the saw blade. Blade temperature was not affected with the vacuum enabled. Clinicians can demonstrate best practices to minimize the risk of cast saw injuries.


Assuntos
Queimaduras , Moldes Cirúrgicos , Queimaduras/prevenção & controle , Humanos , Temperatura
5.
Spine Deform ; 10(1): 115-120, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34279818

RESUMO

PURPOSE: Describe the experience of one institution in modifying allogeneic blood transfusion protocols for AIS surgery in response to the results of ACS-NSQIP-PEDS comparative data in a retrospective cohort study. METHODS: NSQIP data demonstrated that AIS patients at our hospital had a significantly greater risk of ALBT compared to similar institutions (OR 4.1). The ALBT protocol was then revised to initiate transfusion based on Hb/Hct level, clinical hypotension and/or discussion between surgeon and anesthesiologist. A retrospective analysis of perioperative ALBT and autologous cell salvage blood transfusion (CSBT) rates was performed for patients undergoing surgery before (Group A) and after (Group B) the implementation of the revised protocol. RESULTS: Two hundred and ninety patients constituted the study cohort, with 92 patients in Group A and 198 in Group B. Average total blood transfusion (ALBT + CSBT) per patient was significantly lower for Group B than Group A (313 ml vs. 650 ml, p < 0.01). ALBT per patient of Group B was significantly lower than Group A (85 ml vs. 324 ml, p < 0.01). 48% of patients received ALBT in Group A compared to only 18% in Group B. CONCLUSION: Recognition of excessive allogeneic transfusion rates in our institution through comparative data from the ACS-NSQIP-PEDS database resulted in the modification of transfusion parameters that led to a decrease in allogeneic transfusion rates for AIS patients. The current study highlights the value of a large, well-curated surgical database in optimizing clinical protocols and potentially improving overall surgical morbidity.


Assuntos
Transplante de Células-Tronco Hematopoéticas , Escoliose , Fusão Vertebral , Transfusão de Sangue , Humanos , Segurança do Paciente , Complicações Pós-Operatórias , Estudos Retrospectivos , Escoliose/cirurgia , Fusão Vertebral/métodos
6.
Bioengineering (Basel) ; 9(10)2022 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-36290568

RESUMO

The treatment of scoliosis has been explored and debated in medicine since the first recorded texts. Scoliosis treatment has shifted over time from external modalities, such as traction and bracing, to internal stabilization techniques that leverage surgical advances. Surgical fixation constructs can generally be separated into two different modalities: dynamic vs. static constructs. For skeletally immature individuals with progressive deformities, surgical options range from traditional or magnetically controlled growing rods to vertebral body staples or tethering. For individuals who have reached skeletal maturity, many devices have been developed that provide static length constructs. Understanding the surgical options available is critical for the appropriate management of this varied patient population. With this article, we sought to provide a summary of past and present techniques and devices used in the treatment of scoliosis.

7.
BMC Med Educ ; 10: 41, 2010 Jun 07.
Artigo em Inglês | MEDLINE | ID: mdl-20529301

RESUMO

BACKGROUND: No published reports of studies have provided aggregate data on visiting medical student (VMS) programs at allopathic medical schools. METHODS: During 2006, a paper survey was mailed to all 129 allopathic medical schools in the United States and Puerto Rico using a list obtained from the Association of American Medical Colleges. Contents of the survey items were based on existing literature and expert opinion and addressed various topics related to VMS programs, including organizational aspects, program objectives, and practical issues. Responses to the survey items were yes-or-no, multiple-choice, fill-in-the-blank, and free-text responses. Data related to the survey responses were summarized using descriptive statistics. RESULTS: Representatives of 76 schools (59%) responded to the survey. Of these, 73 (96%) reported their schools had VMS programs. The most common reason for having a VMS program was "recruitment for residency programs" (90%). "Desire to do a residency at our institution" was ranked as the leading reason visiting medical students choose to do electives or clerkships. In descending order, the most popular rotations were in internal medicine, orthopedic surgery, emergency medicine, and pediatrics. All VMS programs allowed fourth-year medical students, and approximately half (58%) allowed international medical students. The most common eligibility requirements were documentation of immunizations (92%), previous clinical experience (85%), and successful completion of United States Medical Licensing Examination Step 1 (51%). Of the programs that required clinical experience, 82% required 33 weeks or more. Most institutions (96%) gave priority for electives and clerkships to their own students over visiting students, and a majority (78%) reported that visiting students were evaluated no differently than their own students. During academic year 2006-2007, the number of new resident physicians who were former visiting medical students ranged widely among the responding institutions (range, 0-76). CONCLUSIONS: Medical schools' leading reason for having VMS programs is recruitment into residency programs and the most commonly cited reason students participate in these programs is to secure residency positions. However, further research is needed regarding factors that determine the effectiveness of VMS programs in residency program recruitment and the development of more universal standards for VMS eligibility requirements and assessment.


Assuntos
Estágio Clínico , Terapias Complementares , Faculdades de Medicina , Estudantes de Medicina , Coleta de Dados , Humanos , Porto Rico , Estados Unidos
8.
JBJS Case Connect ; 10(3): e20.00022, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32910621

RESUMO

CASE: A 16-year-old boy underwent closed reduction and pinning of a Salter-Harris II distal radius fracture (DRF). Extensor pollicis longus (EPL) rupture occurred 6 weeks after the injury. Extensor indicis proprius transfer was performed using wide-awake local anesthesia no tourniquet (WALANT) technique. Active thumb range of motion was restored, and the patient returned to all activities, including sports, after 2 months. CONCLUSION: Although delayed attritional EPL rupture after DRF is a well-known complication in adults, this is the first reported case in a truly skeletally immature patient. Awareness of this complication prompts monitoring for prodromal signs and symptoms. The WALANT technique is feasible in selected children.


Assuntos
Fixação Interna de Fraturas , Complicações Pós-Operatórias/cirurgia , Fraturas do Rádio/cirurgia , Traumatismos dos Tendões/cirurgia , Traumatismos do Punho/cirurgia , Adolescente , Anestesia Local , Humanos , Masculino , Radiografia , Fraturas do Rádio/diagnóstico por imagem , Transferência Tendinosa
9.
Artigo em Inglês | MEDLINE | ID: mdl-32656475

RESUMO

Closed reduction and percutaneous pinning (CRPP) for supracondylar humeral fractures (SCHF) comprised considerable surgical volume in pediatric orthopaedics. Limited reports are available on how standardization of the surgical care affects the cost and trainee's learning experience. Methods: Cost analysis was performed by chart review with the billing department in a university teaching hospital. The association of cost with perioperative variables was determined by univariate and multivariable analyses. The educational experience was acquired by questionnaires completed by seven attending surgeons and 22 orthopaedic trainees. Results: Fifty-one patients were included, revealing the hospital charge of $6,345 per CRPP case. Most of the cost comprised OR time (67%) and anesthesia time (13%). The attending surgeon and fracture type were independently associated with anesthesia time. Standardization of care was perceived for better learning experience and cost saving. Conclusion: Efforts in the standardization of SCHF surgical care can improve cost saving and trainees' learning experience.


Assuntos
Fixação Intramedular de Fraturas , Fraturas do Úmero , Ortopedia , Cirurgiões , Criança , Humanos , Fraturas do Úmero/cirurgia , Úmero
10.
Orthopedics ; 43(5): e454-e459, 2020 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-32745224

RESUMO

This was a retrospective study of data prospectively collected from 2012 to 2016 from the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database. The objective was to evaluate the effect of pediatric fellowship training on 30-day perioperative morbidity and mortality following posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS). Several pathways exist in North America by which physicians acquire the clinical and technical skills to manage AIS surgically. Previous work has noted that surgeons with pediatric fellowship training tend to perform the bulk of pediatric spine surgeries. However, no study has been performed that examines if pediatric fellowship training (PFT) has an impact on early postoperative outcomes. A total of 14,194 AIS surgical patients were identified from the ACS NSQIP database. A cohort receiving isolated PSF was abstracted from this group and separated into 3 groups according to surgeon training: (1) ped+ (with PFT, n=4455); (2) ped-(without PFT, n=325); and (3) ped+match (patients selected from ped+ matched to ped- for age, sex, and fusion levels, n=325). The groups were compared for 30-day perioperative morbidity and mortality. No significant differences were noted for the 3 groups in terms of wound infections, length of hospital stay, readmissions, and unplanned returns to the operating room. Ped+match and ped- groups had no difference in neurologic injury rates. However, the ped+ and ped+match groups had significantly lower rates of blood transfusion and average volume of blood lost compared with the ped- group. Surgeons with pediatric fellowship training have a significantly lower average blood loss volume and blood transfusion rate in PSF for AIS than surgeons without such training. Understanding that different training pathways for surgeons may directly impact operative outcomes invites further examination of surgical education in North America to improve training consistency. [Orthopedics. 2020;43(5):e454-e459.].


Assuntos
Complicações Intraoperatórias/etiologia , Complicações Pós-Operatórias/etiologia , Escoliose/cirurgia , Especialização , Fusão Vertebral/efeitos adversos , Adolescente , Transfusão de Sangue , Criança , Bases de Dados Factuais , Feminino , Humanos , Tempo de Internação , Masculino , Estudos Retrospectivos , Resultado do Tratamento
11.
Med Teach ; 31(6): 518-21, 2009 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-18937135

RESUMO

BACKGROUND: Clinician-educators are encouraged to engage in scholarly activity despite numerous barriers to conducting educational research. We found no reports of formal educational research groups among general internists. AIM: To evaluate a Scholarship in Medical Education Group (SIMEG) for general internists. METHODS: The setting is a Division of General Internal Medicine at a large academic medical center. In 2005 twenty-two faculty members formed SIMEG to collaborate on educational research and award protected days for scholarly education projects. Through monthly dialogue and literature review, standards for critiquing educational research were created. RESULTS: A total of 63 protected days were awarded to successful applicants. SIMEG members' curriculum vitae were monitored over two years. From 2005 to 2006, SIMEG members' presentations (15 to 29; p=0.125), peer-reviewed publications (8 to 27; p=0.016) and collaborative projects (19 to 42; p=0.047) increased. CONCLUSIONS: Our educational research group enjoyed improving scholarly productivity over two years. Keys to success were supportive leadership, a culture of collaboration, creating a useful framework for critiquing research, and involving medical learners as co-investigators. Since faculty members are pressured to teach and care for patients while maintaining scholarly productivity, groups like SIMEG should become increasingly valued.


Assuntos
Centros Médicos Acadêmicos , Currículo , Educação Médica , Docentes de Medicina , Pesquisa , Humanos , Minnesota , Desenvolvimento de Programas , Avaliação de Programas e Projetos de Saúde , Pesquisadores
12.
Spine Deform ; 7(6): 870-874, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31731996

RESUMO

STUDY DESIGN: Retrospective review. OBJECTIVES: To evaluate the incidence of adolescent idiopathic scoliosis (AIS) curve progression and brace prescription in skeletally immature patients (Risser 0 to Risser 1) with curves 15°-24°. SUMMARY OF BACKGROUND DATA: Many skeletally immature patients with mild AIS ask about the likelihood of curve progression. No studies have answered these questions. METHODS: The charts and radiographs of 302 consecutive patients with curves 15°-24° at initial visit, Risser 0 to Risser 1, were reviewed until skeletal maturity (≥Risser 4) or surgery. Curves averaged 19.1° ± 2.9° at initial visit. The Risser grade was 0 in 247 patients (82%) and 1 in 55 patients (18%). Patients who were Risser 0 were compared with those who were Risser 1, curves 15°-19° were compared with curves 20°-24°. RESULTS: The majority of patients demonstrated curve progression ≥5° (65%). Patients who were Risser 0 did not progress significantly more than patients who were Risser 1 (10° vs. 8°) (p = .22). Patients with curves 20°-24° did not progress significantly more than patients with curves 15°-19° (10° vs. 9°) (p = .65). CONCLUSIONS: Curve progression for small curves (15°-19°) is similar to curves between 20° and 24°. Close observation or perhaps early intervention for these patients is necessary. These data may suggest a paradigm shift to earlier brace initiation and call for early treatment in small curves. LEVEL OF EVIDENCE: Level II.


Assuntos
Braquetes/efeitos adversos , Escoliose/diagnóstico por imagem , Escoliose/terapia , Curvaturas da Coluna Vertebral/diagnóstico por imagem , Adolescente , Braquetes/normas , Criança , Progressão da Doença , Feminino , Humanos , Incidência , Masculino , Radiografia/métodos , Estudos Retrospectivos , Escoliose/epidemiologia , Prevenção Secundária/métodos , Fatores de Tempo
13.
Foot Ankle Clin ; 13(2): 199-219, v, 2008 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-18457769

RESUMO

Cavovarus foot deformity in children has numerous etiologies with a general pathophysiologic mechanism of muscle imbalance. It is of great importance in the evaluation of a child with a cavovarus foot to determine the underlying cause of the deformity, as the most common origin is a progressive neurologic condition that may be complicated by other orthopedic problems. Treatment options typically are surgical, with limited indications for nonsurgical modalities, and must consider the age of the patient, the nature of the neurologic disease, and the severity of the deformity. Current surgical procedures can be divided into soft tissue procedures to rebalance the muscle forces, osteotomies, and triple arthrodesis. Triple arthrodesis is considered a salvage procedure reserved for the older child with severe, rigid deformity who has failed other surgical treatments.


Assuntos
Deformidades do Pé/diagnóstico , Criança , Diagnóstico Diferencial , Ossos do Pé/patologia , Ossos do Pé/cirurgia , Deformidades do Pé/cirurgia , Humanos
14.
Spine J ; 18(4): 648-654, 2018 04.
Artigo em Inglês | MEDLINE | ID: mdl-28870838

RESUMO

BACKGROUND CONTEXT: Many pelvic fixation options exist for posterior spinal fusion of pediatric neuromuscular scoliosis, including standard iliac screws (SISs) or a more recently introduced S2-Alar (S2A) technique. However, little data exist comparing the clinical and radiographic outcomes of these techniques. PURPOSE: This study aimed to dentify differences in clinical and radiographic outcomes for pediatric neuromuscular scoliosis patients treated with SIS or S2A pelvic fixation. STUDY DESIGN/SETTING: This was a retrospective cohort study at a pediatric orthopedic clinic. PATIENT SAMPLE: Patients aged 8-19 years undergoing posterior spinal fusion to the pelvis for neuromuscular scoliosis using SIS or S2A technique, with Gross Motor Function Classification System (GMFCS) Level 4 or 5 were included. OUTCOMES MEASURES: Postoperative complication rates associated with pelvic fixation method were the outcome measures. METHODS: Charts and radiographs were reviewed for demographics, intra- and postoperative course, levels of instrumentation, operative correction, and implant failure (IF). Postoperative complications were classified according to the Accordion scale. RESULTS: We studied 50 patients (28 SIS, 22 S2A) aged 14.0±2.8 years and an average follow-up of 3.5±1.7 years. The average number of levels fused was 16.5±1.1 with an average curve correction of 48°±21° postoperatively. A significant difference in radiographic IF rates was noted between SIS and S2A groups (57% vs. 27%, p=.02). No difference was noted between groups for frequency or severity of postoperative complications, inclusive of wound infections. Subgroup analysis demonstrated equivalent IF rates when comparing the S2A group with the SIS group with cross-links. CONCLUSIONS: The S2A group generally demonstrated improved rates of radiographic IF compared with the SIS group, but the rates became equivalent when a cross-link was added to an SIS construct. Further, no difference in postoperative complication rates were identified between SIS and S2A groups.


Assuntos
Parafusos Ósseos/efeitos adversos , Ílio/cirurgia , Complicações Pós-Operatórias/epidemiologia , Escoliose/cirurgia , Fusão Vertebral/métodos , Adolescente , Criança , Falha de Equipamento/estatística & dados numéricos , Feminino , Humanos , Masculino , Complicações Pós-Operatórias/etiologia , Fusão Vertebral/efeitos adversos , Adulto Jovem
15.
Artigo em Inglês | MEDLINE | ID: mdl-29889948

RESUMO

Physical activity (PA) may improve quality of life and survival among cancer survivors; however, little is known about Navajo cancer survivor PA. We evaluated Navajo cancer survivor PA habits, barriers, and preferences through focus groups and interviews (n = 32). Transcripts were coded in NVivo and major themes summarized by consensus. Survivor exercise guidelines were largely unknown, but movement, resilience and life balance were valued. Most participants reported at ≥1 mode of current PA (n = 24; 71% walking, 46% work/homesteading). Barriers to PA included treatment side effects, limited access to programs, fear of "over doing it," and family/friends encouraging rest. Preferences for PA varied.


Assuntos
Sobreviventes de Câncer/estatística & dados numéricos , Terapia por Exercício/estatística & dados numéricos , Exercício Físico , Acessibilidade aos Serviços de Saúde/estatística & dados numéricos , Indígenas Norte-Americanos/etnologia , Aceitação pelo Paciente de Cuidados de Saúde/etnologia , Adulto , Idoso , Arizona/etnologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pesquisa Qualitativa
16.
J Bone Joint Surg Am ; 89(1): 102-13, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17200317

RESUMO

BACKGROUND: The mechanism of physeal closure is poorly understood, although both mechanical and biological factors may play a role in the process. In this study, we evaluated the effect of the application of a chemokine stromal cell-derived factor-1 (SDF-1) to rabbit physes in vivo with regard to growth inhibition. METHODS: A continuous infusion system consisting of a fenestrated catheter and an osmotic pump were implanted into the right proximal tibial physis of twenty six-week-old New Zealand White rabbits. Ten of the pumps were loaded with human recombinant SDF-1alpha, and ten were loaded with phosphate-buffered saline solution (sham treatment). The left leg was used as the uninvolved control. The growth of the tibiae was followed radiographically for eight weeks, and histologic analysis was performed for both the SDF-1-treated rabbits and the sham-treated rabbits at two, four, and eight-week time-points. RESULTS: Radiographic evaluation showed a significant growth inhibition in the SDF-1alpha-treated physes (4.5 +/- 3.0 mm; p = 0.007) compared with the sham-treated physes after eight weeks. No difference was noted when the sham-treated leg was compared with the contralateral, control leg (0.2 +/- 2.9 mm; p = 0.465). Histologic evaluation showed marked physeal disorganization, narrowing, and proteoglycan loss and a significant decrease in physeal height (p < 0.0001) for the SDF-1-treated group. Reversible growth slowing was noted in the uninvolved, control leg of the SDF-1-treated group at six weeks, with resolution of the difference by eight weeks. CONCLUSIONS: SDF-1 may be used to induce physeal closure through a targeted infusion system. However, transient systemic effects of SDF-1 may exist and must be evaluated further prior to its clinical use for epiphysiodesis.


Assuntos
Desenvolvimento Ósseo/efeitos dos fármacos , Quimiocinas CXC/farmacologia , Epífises/efeitos dos fármacos , Tíbia/efeitos dos fármacos , Animais , Cartilagem Articular/anatomia & histologia , Quimiocina CXCL12 , Quimiocinas CXC/administração & dosagem , Epífises/crescimento & desenvolvimento , Epífises/patologia , Indicadores e Reagentes , Bombas de Infusão , Azul de Metileno , Coelhos , Tíbia/crescimento & desenvolvimento
17.
J Eval Clin Pract ; 13(3): 321-5, 2007 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-17518794

RESUMO

RATIONALE, AIMS AND OBJECTIVES: Advances in medicine have led to a multitude of diagnostic tests. The contribution of the clinical skills of the general internist in the context of all these advances is unknown. Our objective was to assess the relative contributions of clinical skills and diagnostic test results in arriving at a final diagnosis. METHODS: Records were retrospectively reviewed from 248 consecutive patients admitted to a general internal medicine hospital service during a 3-month period in 2000. All diagnostic evaluations that yielded the final diagnosis were recorded along with the date and time they were performed. Diagnostic credit was given to the evaluation that yielded the diagnosis at the earliest point in time. RESULTS: All cases had a firm diagnosis by 3 months after hospitalization. Of the 248 patients, 246 received a final diagnosis during hospitalization. The diagnoses were made by use of the clinical judgement of the general internist in 50.4% of the cases, a radiologic study in 31.7%, a blood test or culture result in 9.4%, biopsy findings in 3.3% and various other diagnostic studies (endoscopy, echocardiography, electromyography and electroencephalography) in 5.2%. Clinicians provided the correct diagnosis significantly more often than radiologic studies (P = 0.0015), which was the next most useful type of diagnostic evaluation. CONCLUSION: Although technology has become increasingly available in clinical practice, clinical expertise and skills are still important factors with respect to making correct, timely diagnoses in hospitalized patients.


Assuntos
Competência Clínica , Diagnóstico Diferencial , Testes Diagnósticos de Rotina , Humanos , Auditoria Médica , Estudos Retrospectivos , Estados Unidos
18.
Orthopedics ; 40(4): e623-e627, 2017 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-28437549

RESUMO

Plain pelvic radiographs are commonly used for a variety of pediatric orthopedic disorders. Lead shielding is typically placed over the gonads to minimize radiation exposure to these sensitive tissues. However, misplaced shielding can sabotage efforts to protect patients from excessive radiation exposure either by not covering radiosensitive tissues or by obscuring anatomic areas of interest, prompting repeat radiographic examinations. The goal of this study was to determine the incidence of misplaced shielding for pelvic radiographs obtained for pediatric orthopedic evaluation. Children 8 to 16 years old who had an anteroposterior or frog lateral pelvic radiograph between 2008 and 2014 were included. A total of 3400 patients met the inclusion criteria, and 84 boys and 84 girls were randomly selected for review. For both boys and girls, the percentage of incorrectly positioned or missing shields was calculated. Chi-square testing was used to compare the frequency of missing or incorrectly placed shields between sexes and age groups. Pelvic shields were misplaced in 49% of anteroposterior and 63% of frog lateral radiographs. Shielding was misplaced more frequently for girls than for boys on frog lateral radiographs (76% vs 51%; P<.05). Pelvic bony landmarks were often obscured by pelvic shielding, with a frequency of 7% to 43%, depending on the specific landmark. The femoral head and acetabulum were obscured by shielding in up to 2% of all images. The findings suggest that accepted pelvic shielding protocols are ineffective. Consideration should be given to alternative protocols or abandonment of this practice. [Orthopedics. 2017; 40(4):e623-e627.].


Assuntos
Tratamentos com Preservação do Órgão/normas , Pelve/diagnóstico por imagem , Exposição à Radiação/prevenção & controle , Proteção Radiológica/normas , Acetábulo/efeitos da radiação , Adolescente , Pontos de Referência Anatômicos/diagnóstico por imagem , Criança , Feminino , Cabeça do Fêmur/diagnóstico por imagem , Cabeça do Fêmur/efeitos da radiação , Gônadas/efeitos da radiação , Humanos , Masculino , Doenças Musculoesqueléticas/diagnóstico por imagem , Procedimentos Ortopédicos/métodos , Ossos Pélvicos/diagnóstico por imagem , Ossos Pélvicos/efeitos da radiação , Exame Físico/métodos , Exposição à Radiação/normas , Radiografia , Estudos Retrospectivos
19.
Orthopedics ; 40(5): e849-e854, 2017 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-28776629

RESUMO

The purpose of this study was to determine the rate of cast-related complications when using split or intact casts. A total of 60 patients aged 3 to 13 years with closed shaft or distal third radius and ulna fractures requiring reduction were recruited for this study. Patients underwent closed reduction under sedation and were placed into a long-arm fiberglass cast with 1 of 3 modifications: no valve, univalve, or bivalve. Patients were followed to 6 weeks after reduction or surgical treatment if required. The frequency of neurovascular injury, cast saw injury, unplanned office visits, and cast modifications, the need for operative intervention, and pain levels through the follow-up period were recorded. The results showed no incidents of compartment syndrome or neurovascular injury. Additionally, there were no differences between complications associated with cast type (P=.266), frequency of cast modifications (P=.185), or subsequent need for surgical stabilization (P=.361). Therefore, cast splitting following closed reduction of low-energy pediatric forearm fractures does not change clinical outcomes with respect to neurovascular complications, cast modifications, pain levels, or the need for repeat reduction. Consideration should be given to minimizing cast splitting after reduction of low-energy pediatric forearm fractures for practice efficiency and to potentially decrease saw-related injury. [Orthopedics. 2017; 40(5):e849-e854.].


Assuntos
Moldes Cirúrgicos/efeitos adversos , Fraturas do Rádio/cirurgia , Fraturas da Ulna/cirurgia , Adolescente , Criança , Pré-Escolar , Síndromes Compartimentais/etiologia , Feminino , Traumatismos do Antebraço/cirurgia , Vidro , Humanos , Masculino , Estudos Prospectivos , Contenções , Resultado do Tratamento , Traumatismos do Punho/cirurgia
20.
Orthop Clin North Am ; 37(2): 119-32, v, 2006 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-16638443

RESUMO

The child's hip begins in intrauterine development as a condensation of mesoderm in the lower limb bud that rapidly differentiates to resemble the adult hip by eight weeks of life. The developmental instructions are transmitted through complicated cell signaling pathways. From eight weeks of development to adolescence, further growth of the hip is focused on differentiation and the establishment of the adult arterial supply. The postnatal growth of the child's hip is a product of concurrent acetabular and proximal femoral growth from their corresponding growth plates. Absence of appropriate contact between acetabulum and proximal femur yields an incongruent joint. Multiple disease processes may be understood in light of this growth process, including Legg-Calvé-Perthes disease and developmental dysplasia of the hip.


Assuntos
Feto/anatomia & histologia , Quadril/embriologia , Quadril/crescimento & desenvolvimento , Acetábulo/irrigação sanguínea , Acetábulo/embriologia , Cartilagem Articular/embriologia , Criança , Desenvolvimento Embrionário/fisiologia , Fêmur/embriologia , Desenvolvimento Fetal/fisiologia , Feto/embriologia , Luxação Congênita de Quadril/embriologia , Luxação Congênita de Quadril/genética , Humanos , Articulações/embriologia , Doença de Legg-Calve-Perthes/embriologia , Osteogênese/fisiologia
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