Detalhe da pesquisa
1.
Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag.
Nat Methods;
20(6): 898-907, 2023 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37156841
2.
A flexible split prime editor using truncated reverse transcriptase improves dual-AAV delivery in mouse liver.
Mol Ther;
30(3): 1343-1351, 2022 03 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34998953
3.
AAV5 delivery of CRISPR-Cas9 supports effective genome editing in mouse lung airway.
Mol Ther;
30(1): 238-243, 2022 01 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34695545
4.
YAP1 Withdrawal in Hepatoblastoma Drives Therapeutic Differentiation of Tumor Cells to Functional Hepatocyte-Like Cells.
Hepatology;
73(3): 1011-1027, 2021 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32452550
5.
Tissue-restricted genome editing in vivo specified by microRNA-repressible anti-CRISPR proteins.
RNA;
25(11): 1421-1431, 2019 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31439808
6.
Increased sensitivity to apoptosis upon endoplasmic reticulum stress-induced activation of the unfolded protein response in chemotherapy-resistant malignant pleural mesothelioma.
Br J Cancer;
119(1): 65-75, 2018 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29921948
7.
AAV5 delivery of CRISPR/Cas9 mediates genome editing in the lungs of young rhesus monkeys.
Hum Gene Ther;
2024 May 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38767512
8.
Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing.
Nat Biotechnol;
41(10): 1410-1415, 2023 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36997680
9.
MEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma.
Cell Death Discov;
9(1): 55, 2023 Feb 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36765038
10.
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors.
CRISPR J;
6(6): 570-582, 2023 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38108517
11.
A split prime editor with untethered reverse transcriptase and circular RNA template.
Nat Biotechnol;
40(9): 1388-1393, 2022 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35379962
12.
Genome-wide detection of CRISPR editing in vivo using GUIDE-tag.
Nat Commun;
13(1): 437, 2022 01 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35064134
13.
Metabolic synthetic lethality by targeting NOP56 and mTOR in KRAS-mutant lung cancer.
J Exp Clin Cancer Res;
41(1): 25, 2022 Jan 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35039048
14.
Malignant pleural mesothelioma co-opts BCL-XL and autophagy to escape apoptosis.
Cell Death Dis;
12(4): 406, 2021 04 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33859162
15.
Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice.
Nat Commun;
12(1): 2121, 2021 04 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33837189
16.
CRISPR-Mediated Kinome Editing Prioritizes a Synergistic Combination Therapy for FGFR1-Amplified Lung Cancer.
Cancer Res;
81(11): 3121-3133, 2021 06 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33685992
17.
Synergistic effects of FGFR1 and PLK1 inhibitors target a metabolic liability in KRAS-mutant cancer.
EMBO Mol Med;
13(9): e13193, 2021 09 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34369083
18.
CRISPR Screening Identifies WEE1 as a Combination Target for Standard Chemotherapy in Malignant Pleural Mesothelioma.
Mol Cancer Ther;
19(2): 661-672, 2020 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31694888
19.
All types of base conversions allowed by base editors.
Sci China Life Sci;
67(2): 431-433, 2024 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37930476
20.
New Horizons in KRAS-Mutant Lung Cancer: Dawn After Darkness.
Front Oncol;
9: 953, 2019.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31612108