[Effects of Shengmai Jianghuang San on intestinal flora in nude mice with radio resistant cells of nasopharyngeal carcinoma].

Modern pharmacological studies have shown that Shengmai San has the effects of enhancing immunity and improving blood circulation, and Curcumae Longae Rhizoma(Jianghuang) has anti-inflammatory, anti-cancer, anti-oxidation and other functions. Shengmai San combined with Jianghuang is a new research direction in the study of anti-tumor of traditional Chinese medicines. The main treatment for nasopharyngeal carcinoma is radiation therapy, but radiation therapy can cause a variety of side effects, and it also changes the composition of the intestinal flora. In this study, the 16 s rDNA sequencing platform was used to perform macro-sequence sequencing of the intestinal flora samples of nude mice bearing the veins of Shengmai Jianghuang San, and then the results of intestinal flora data were analyzed to investigate the effect of Shengmai Jianghuang San on tumors. The results showed that Shengmai Jianghuang San combined with irradiation could enhance the therapeutic effect of tumor treatment. Radiation therapy would reduce the total number and diversity of intestinal flora in nude mice, and also change the structure of the flora. Shengmai Jianghuang San could protect the diversity of colonies, and also partially restore the colony imbalance caused by irradiation. This study provides a research idea for Shengmai Jianghuang San as a sensitizing adjuvant for radiotherapy of nasopharyngeal carcinoma.

Effect of curcumin on rats/mice with diabetic nephropathy: a systematic review and meta-analysis of randomized controlled trials.

OBJECTIVE: To assess the renal protective effects of curcumin administration on diabetic rats/mice. METHODS: Databases were searched electronically and conference papers searched manually for search terms to find relevant studies. Articles were assessed independently by two reviewers. Review Manager 5.1 was used for data analysis. RESULTS: Fourteen randomized controlled experiments were included. Meta-analysis demonstrated that blood sugar levels and kidney weight to body weight ratios in the model group were higher than those in the normal group, and the curcumin group had significantly lower mesangial area to glomerular area ratios compared with the model group, and also lower levels of urinary protein, blood urea nitrogen and serum creatinine. CONCLUSION: Curcumin shows protective effects on the kidneys of rats/mice with diabetes.

Comparative analysis on indoor and outdoor thermal comfort in transitional seasons and summer based on multiple databases: Lessons learnt from the outdoors.

In environments with similar physical parameters, thermal comfort and sensation feelings may differ indoors and outdoors. How indoor and outdoor thermal perception differ from each other remains unclear. This study compared and discussed 29,536 field survey data, including 19,191 sets of indoor data, and 10,345 sets of outdoor data, covering five Köppen climate zones during transitional seasons and summer. Indoor data points were collected from two databases: the ASHRAE Global Thermal Comfort II and the SCATs (Smart Controls and Thermal Comfort), while outdoor data points were collected from the RUROS database (Rediscovering the Urban Realm and Open Spaces) and five individual projects executed in Singapore, Hong Kong, Guangzhou, Changsha, and Tianjin. The concepts of neutral rate (NR) and comfort rate (CR) were developed to help categorize "neutral" and "comfort" across different studies. The results of this study show that people are less sensitive to changes in thermal environment outdoors than indoors. Moreover, thermal comfort cannot be simply treated as thermal neutral, particularly for outdoor spaces. Compared with MM (mixed-mode) and NV (naturally ventilated) spaces, outdoor space does not have the highest NR, but its CR is much higher, with a wide range of SET* (Standard Effective Temperature) corresponding to CR over 80 %, from 15.5 °C to 23.4 °C. In the Cfa (humid subtropical) climate zone, significantly higher CR are recorded for outdoor spaces, although the NR are similar or even lower than those of indoors. Natural thermal resources in the outdoor thermal environment may hold the key to extending indoor comfort ranges.

The Impact of the Declaration of the State of Emergency on the Spread of COVID-19: A Modeling Analysis.

When encountering the outbreak and early spreading of COVID-19, the Government of Japan imposed gradually upgraded restriction policies and declared the state of emergency in April 2020 for the first time. To evaluate the efficacy of the countering strategies in different periods, we constructed a SEIADR (susceptible-exposed-infected-asymptomatic-documented-recovered) model to simulate the cases and determined corresponding spreading coefficients. The effective reproduction number R t was obtained to evaluate the measures controlling the COVID-19 conducted by the Government of Japan during different stages. It was found that the strict containing strategies during the state of emergency period drastically inhibit the COVID-19 trend. R t was decreased to 1.1123 and 0.8911 in stages 4 and 5 (a state of emergency in April and May 2020) from 3.5736, 2.0126, 3.0672 in the previous three stages when the containing strategies were weak. The state of emergency was declared again in view of the second wave of massive infections in January 2021. We estimated the cumulative infected cases and additional days to contain the COVID-19 transmission for the second state of emergency using this model. R t was 1.028 which illustrated that the strategies were less effective than the previous state of emergency. Finally, the overall infected population was predicted using combined isolation and testing intensity; the effectiveness and the expected peak time were evaluated. If using the optimized control strategies in the current stage, the spread of COVID-19 in Japan could be controlled within 30 days. The total confirmed cases should reduce to less than 4.2 × 105 by April 2021. This model study suggested stricter isolating measures may be required to shorten the period of the state of emergency.

Effect of cardiac rehabilitation training on patients with coronary heart disease: a systematic review and meta-analysis.

BACKGROUND: In recent years, the incidence of heart disease has increased and patients are younger. Cardiac rehabilitation training has been proposed to improve the prognosis of patients with heart disease. Cardiac rehabilitation includes moderate-intensity continuous training (MCT) and high-intensity interval training (HIIT). These two training methods have different effects in improving the prognosis of patients. The aim of the present study was to improve reference for patients with cardiac rehabilitation. METHODS: English databases, including PubMed, Cochrane Library, and Embase, were searched from the establishment of the database to April 2021 for randomized controlled trials (RCTs) of rehabilitation training at different intensities. RevMan 5.3 was used for the meta-analysis. RESULTS: A total of 8 articles (with a total of 465 patients) were included, including 236 patients in the experimental group and 229 patients in the control group. Different intensities of training had statistically significant differences in peak oxygen uptake [mean difference (MD): 1.21, 95% confidence interval (CI): -0.66 to 3.07, P=0.20] and the left ventricular ejection fraction difference (MD: 2.53, 95% CI: -2.10 to 7.17, P=0.28). DISCUSSION: Cardiac rehabilitation training can effectively improve the patient's cardiac function indicators and self-care ability, and reduce the incidence of cardiovascular disease (CVD). However, large-sample, multicenter, and long-term RCTs are needed to strengthen the findings of the study.