Thermodynamic Definitions of Temperature and Kappa and Introduction of the Entropy Defect.

This paper develops explicit and consistent definitions of the independent thermodynamic properties of temperature and the kappa index within the framework of nonextensive statistical mechanics and shows their connection with the formalism of kappa distributions. By defining the "entropy defect" in the composition of a system, we show how the nonextensive entropy of systems with correlations differs from the sum of the entropies of their constituents of these systems. A system is composed extensively when its elementary subsystems are independent, interacting with no correlations; this leads to an extensive system entropy, which is simply the sum of the subsystem entropies. In contrast, a system is composed nonextensively when its elementary subsystems are connected through long-range interactions that produce correlations. This leads to an entropy defect that quantifies the missing entropy, analogous to the mass defect that quantifies the mass (energy) associated with assembling subatomic particles. We develop thermodynamic definitions of kappa and temperature that connect with the corresponding kinetic definitions originated from kappa distributions. Finally, we show that the entropy of a system, composed by a number of subsystems with correlations, is determined using both discrete and continuous descriptions, and find: (i) the resulted entropic form expressed in terms of thermodynamic parameters; (ii) an optimal relationship between kappa and temperature; and (iii) the correlation coefficient to be inversely proportional to the temperature logarithm.

Effects of Cholesterol in Stress-Related Neuronal Death-A Statistical Analysis Perspective.

The association between plasma cholesterol levels and the development of dementia continues to be an important topic of discussion in the scientific community, while the results in the literature vary significantly. We study the effect of reducing oxidized neuronal cholesterol on the lipid raft structure of plasma membrane. The levels of plasma membrane cholesterol were reduced by treating the intact cells with methyl-ß-cyclodextrin (MßCD). The relationship between the cell viability with varying levels of MßCD was then examined. The viability curves are well described by a modified form of the empirical Gompertz law of mortality. A detailed statistical analysis is performed on the fitting results, showing that increasing MßCD concentration has a minor, rather than significant, effect on the cellular viability. In particular, the dependence of viability on MßCD concentration was found to be characterized by a ~25% increase per 1 µM of MßCD concentration.

Nonextensive Statistical Mechanics: Equivalence Between Dual Entropy and Dual Probabilities.

The concept of duality of probability distributions constitutes a fundamental "brick" in the solid framework of nonextensive statistical mechanics-the generalization of Boltzmann-Gibbs statistical mechanics under the consideration of the q-entropy. The probability duality is solving old-standing issues of the theory, e.g., it ascertains the additivity for the internal energy given the additivity in the energy of microstates. However, it is a rather complex part of the theory, and certainly, it cannot be trivially explained along the Gibb's path of entropy maximization. Recently, it was shown that an alternative picture exists, considering a dual entropy, instead of a dual probability. In particular, the framework of nonextensive statistical mechanics can be equivalently developed using q- and 1/q- entropies. The canonical probability distribution coincides again with the known q-exponential distribution, but without the necessity of the duality of ordinary-escort probabilities. Furthermore, it is shown that the dual entropies, q-entropy and 1/q-entropy, as well as, the 1-entropy, are involved in an identity, useful in theoretical development and applications.

Statistical Uncertainties of Space Plasma Properties Described by Kappa Distributions.

The velocities of space plasma particles often follow kappa distribution functions, which have characteristic high energy tails. The tails of these distributions are associated with low particle flux and, therefore, it is challenging to precisely resolve them in plasma measurements. On the other hand, the accurate determination of kappa distribution functions within a broad range of energies is crucial for the understanding of physical mechanisms. Standard analyses of the plasma observations determine the plasma bulk parameters from the statistical moments of the underlined distribution. It is important, however, to also quantify the uncertainties of the derived plasma bulk parameters, which determine the confidence level of scientific conclusions. We investigate the determination of the plasma bulk parameters from observations by an ideal electrostatic analyzer. We derive simple formulas to estimate the statistical uncertainties of the calculated bulk parameters. We then use the forward modelling method to simulate plasma observations by a typical top-hat electrostatic analyzer. We analyze the simulated observations in order to derive the plasma bulk parameters and their uncertainties. Our simulations validate our simplified formulas. We further examine the statistical errors of the plasma bulk parameters for several shapes of the plasma velocity distribution function.

On the Determination of Kappa Distribution Functions from Space Plasma Observations.

The velocities of space plasma particles, often follow kappa distribution functions. The kappa index, which labels and governs these distributions, is an important parameter in understanding the plasma dynamics. Space science missions often carry plasma instruments on board which observe the plasma particles and construct their velocity distribution functions. A proper analysis of the velocity distribution functions derives the plasma bulk parameters, such as the plasma density, speed, temperature, and kappa index. Commonly, the plasma bulk density, velocity, and temperature are determined from the velocity moments of the observed distribution function. Interestingly, recent studies demonstrated the calculation of the kappa index from the speed (kinetic energy) moments of the distribution function. Such a novel calculation could be very useful in future analyses and applications. This study examines the accuracy of the specific method using synthetic plasma proton observations by a typical electrostatic analyzer. We analyze the modeled observations in order to derive the plasma bulk parameters, which we compare with the parameters we used to model the observations in the first place. Through this comparison, we quantify the systematic and statistical errors in the derived moments, and we discuss their possible sources.

Determining the Bulk Parameters of Plasma Electrons from Pitch-Angle Distribution Measurements.

Electrostatic analysers measure the flux of plasma particles in velocity space and determine their velocity distribution function. There are occasions when science objectives require high time-resolution measurements, and the instrument operates in short measurement cycles, sampling only a portion of the velocity distribution function. One such high-resolution measurement strategy consists of sampling the two-dimensional pitch-angle distributions of the plasma particles, which describes the velocities of the particles with respect to the local magnetic field direction. Here, we investigate the accuracy of plasma bulk parameters from such high-resolution measurements. We simulate electron observations from the Solar Wind Analyser's (SWA) Electron Analyser System (EAS) on board Solar Orbiter. We show that fitting analysis of the synthetic datasets determines the plasma temperature and kappa index of the distribution within 10% of their actual values, even at large heliocentric distances where the expected solar wind flux is very low. Interestingly, we show that although measurement points with zero counts are not statistically significant, they provide information about the particle distribution function which becomes important when the particle flux is low. We also examine the convergence of the fitting algorithm for expected plasma conditions and discuss the sources of statistical and systematic uncertainties.

Non-Extensive Statistical Analysis of Energetic Particle Flux Enhancements Caused by the Interplanetary Coronal Mass Ejection-Heliospheric Current Sheet Interaction.

In this study we use theoretical concepts and computational-diagnostic tools of Tsallis non-extensive statistical theory (Tsallis q-triplet: q s e n ,   q r e l ,   q s t a t ), complemented by other known tools of nonlinear dynamics such as Correlation Dimension and surrogate data, Hurst exponent, Flatness coefficient, and p-modeling of multifractality, in order to describe and understand Small-scale Magnetic Islands (SMIs) structures observed in Solar Wind (SW) with a typical size of ~0.01-0.001 AU at 1 AU. Specifically, we analyze ~0.5 MeV energetic ion time-intensity and magnetic field profiles observed by the STEREO A spacecraft during a rare, widely discussed event. Our analysis clearly reveals the non-extensive character of SW space plasmas during the periods of SMIs events, as well as significant physical complex phenomena in accordance with nonlinear dynamics and complexity theory. As our analysis also shows, a non-equilibrium phase transition parallel with self-organization processes, including the reduction of dimensionality and development of long-range correlations in connection with anomalous diffusion and fractional acceleration processes can be observed during SMIs events.

High Density Nodes in the Chaotic Region of 1D Discrete Maps.

We report on the definition and characteristics of nodes in the chaotic region of bifurcation diagrams in the case of 1D mono-parametrical and S-unimodal maps, using as guiding example the logistic map. We examine the arrangement of critical curves, the identification and arrangement of nodes, and the connection between the periodic windows and nodes in the chaotic zone. We finally present several characteristic features of nodes, which involve their convergence and entropy.

Long-Term Independence of Solar Wind Polytropic Index on Plasma Flow Speed.

The paper derives the polytropic indices over the last two solar cycles (years 1995-2017) for the solar wind proton plasma near Earth (~1 AU). We use ~92-s datasets of proton plasma moments (speed, density, and temperature), measured from the Solar Wind Experiment instrument onboard Wind spacecraft, to estimate the moving averages of the polytropic index, as well as their weighted means and standard errors as a function of the solar wind speed and the year of measurements. The derived long-term behavior of the polytropic index agrees with the results of other previous methods. In particular, we find that the polytropic index remains quasi-constant with respect to the plasma flow speed, in agreement with earlier analyses of solar wind plasma. It is shown that most of the fluctuations of the polytropic index appear in the fast solar wind. The polytropic index remains quasi-constant, despite the frequent entropic variations. Therefore, on an annual basis, the polytropic index of the solar wind proton plasma near ~1 AU can be considered independent of the plasma flow speed. The estimated all-year weighted mean and its standard error is γ = 1.86 ± 0.09.

The theory of thermodynamic relativity.

We introduce the theory of thermodynamic relativity, a unified theoretical framework for describing both entropies and velocities, and their respective physical disciplines of thermodynamics and kinematics, which share a surprisingly identical description with relativity. This is the first study to generalize relativity in a thermodynamic context, leading naturally to anisotropic and nonlinear adaptations of relativity; thermodynamic relativity constitutes a new path of generalization, as compared to the "traditional" passage from special to general theory based on curved spacetime. We show that entropy and velocity are characterized by three identical postulates, which provide the basis of a broader framework of relativity: (1) no privileged reference frame with zero value; (2) existence of an invariant and fixed value for all reference frames; and (3) existence of stationarity. The postulates lead to a unique way of addition for entropies and for velocities, called kappa-addition. We develop a systematic method of constructing a generalized framework of the theory of relativity, based on the kappa-addition formulation, which is fully consistent with both thermodynamics and kinematics. We call this novel and unified theoretical framework for simultaneously describing entropy and velocity "thermodynamic relativity". From the generality of the kappa-addition formulation, we focus on the cases corresponding to linear adaptations of special relativity. Then, we show how the developed thermodynamic relativity leads to the addition of entropies in nonextensive thermodynamics and the addition of velocities in Einstein's isotropic special relativity, as in two extreme cases, while intermediate cases correspond to a possible anisotropic adaptation of relativity. Using thermodynamic relativity for velocities, we start from the kappa-addition of velocities and construct the basic formulations of the linear anisotropic special relativity; e.g., the asymmetric Lorentz transformation, the nondiagonal metric, and the energy-momentum-velocity relationships. Then, we discuss the physical consequences of the possible anisotropy in known relativistic effects, such as, (i) matter-antimatter asymmetry, (ii) time dilation, and (iii) Doppler effect, and show how these might be used to detect and quantify a potential anisotropy.

Entropy defect in thermodynamics.

This paper describes the physical foundations of the newly discovered "entropy defect" as a basic concept of thermodynamics. The entropy defect quantifies the change in entropy caused by the order induced in a system through the additional correlations among its constituents when two or more subsystems are assembled. This defect is closely analogous to the mass defect that arises when nuclear particle systems are assembled. The entropy defect determines how the entropy of the system compares to its constituent's entropies and stands on three fundamental properties: each constituent's entropy must be (i) separable, (ii) symmetric, and (iii) bounded. We show that these properties provide a solid foundation for the entropy defect and for generalizing thermodynamics to describe systems residing out of the classical thermal equilibrium, both in stationary and nonstationary states. In stationary states, the consequent thermodynamics generalizes the classical framework, which was based on the Boltzmann-Gibbs entropy and Maxwell-Boltzmann canonical distribution of particle velocities, into the respective entropy and canonical distribution associated with kappa distributions. In nonstationary states, the entropy defect similarly acts as a negative feedback, or reduction of the increase of entropy, preventing its unbounded growth toward infinity.

Effects of background noise on fit parameters of plasma scattering angle distributions.

The presence of noise in plasma particle measurements by scientific instruments causes inaccuracies in the determined plasma bulk parameters. This study demonstrates and evaluates the effects of noise in the determination of typical distribution functions describing the scattering angles of plasma particles passing through thin foils. First, we simulate measurements of plasma particles passing through a thin carbon foil, considering that their scattering angles follow kappa-like distribution functions, as being addressed in previous studies. We work with these specific distributions because we can produce them in the laboratory. We add Poisson-distributed background noise to the simulated data. We fit the simulated measurements and compare the fit parameters with the input parameters. As expected, we find that the discrepancy between the initial parameters and those derived from the fits increases with the relative increase of the noise. The misestimations exhibit characteristic trends as functions of the signal-to-noise ratio and the input parameters. Second, we examine the scattering angle distributions measured with a laboratory experiment of protons passing through a thin carbon foil for different signal-to-noise ratios. These measurements support the simulation results, although they exhibit a larger discrepancy than found in the simulations. Finally, we discuss how we can improve the accuracy of estimated distribution parameters in space and ground-based applications by excluding data-points from the tails of the distribution functions. Although our results exhibit the effects of noise in a specific type of distribution functions, we explain that this technique can be applied to and optimized for other specific data-sets.

A continuous-time mathematical model and discrete approximations for the aggregation of ß-Amyloid.

Alzheimer's disease is a degenerative disorder characterized by the loss of synapses and neurons from the brain, as well as the accumulation of amyloid-based neuritic plaques. While it remains a matter of contention whether ß-amyloid causes the neurodegeneration, ß-amyloid aggregation is associated with the disease progression. Therefore, gaining a clearer understanding of this aggregation may help to better understand the disease. We develop a continuous-time model for ß-amyloid aggregation using concepts from chemical kinetics and population dynamics. We show the model conserves mass and establish conditions for the existence and stability of equilibria. We also develop two discrete-time approximations to the model that are dynamically consistent. We show numerically that the continuous-time model produces sigmoidal growth, while the discrete-time approximations may exhibit oscillatory dynamics. Finally, sensitivity analysis reveals that aggregate concentration is most sensitive to parameters involved in monomer production and nucleation, suggesting the need for good estimates of such parameters.

Statistical analysis of the impact of environmental temperature on the exponential growth rate of cases infected by COVID-19.

We perform a statistical analysis for understanding the effect of the environmental temperature on the exponential growth rate of the cases infected by COVID-19 for US and Italian regions. In particular, we analyze the datasets of regional infected cases, derive the growth rates for regions characterized by a readable exponential growth phase in their evolution spread curve and plot them against the environmental temperatures averaged within the same regions, derive the relationship between temperature and growth rate, and evaluate its statistical confidence. The results clearly support the first reported statistically significant relationship of negative correlation between the average environmental temperature and exponential growth rates of the infected cases. The critical temperature, which eliminates the exponential growth, and thus the COVID-19 spread in US regions, is estimated to be TC = 86.1 ± 4.3 F0.

A discrete mathematical model for the aggregation of ß-Amyloid.

Dementia associated with the Alzheimer's disease is thought to be correlated with the conversion of the ß - Amyloid (Aß) peptides from soluble monomers to aggregated oligomers and insoluble fibrils. We present a discrete-time mathematical model for the aggregation of Aß monomers into oligomers using concepts from chemical kinetics and population dynamics. Conditions for the stability and instability of the equilibria of the model are established. A formula for the number of monomers that is required for producing oligomers is also given. This may provide compound designers a mechanism to inhibit the Aß aggregation.

Hierarchical competition models with the Allee effect II: the case of immigration.

This is part II of an earlier paper that dealt with hierarchical models with the Allee effect but with no immigration. In this paper, we greatly simplify the proofs in part I and provide a proof of the global dynamics of the non-hyperbolic cases that were previously conjectured. Then, we show how immigration to one of the species or to both would, drastically, change the dynamics of the system. It is shown that if the level of immigration to one or to both species is above a specified level, then there will be no extinction region where both species go to extinction.

Hierarchical competition models with Allee effects.

We consider a two-species hierarchical competition model with a strong Allee effect. The Allee effect is assumed to be caused by predator saturation. Moreover, we assume that there is a 'silverback' species x that gets first choice of the resources and where growth is limited by its own intraspecific competition, while the second 'inferior' species y gets whatever is left. Both species x and y are assumed to have the property of strong Allee effect. In this paper we determine the impact of the presence of the Allee effect on the global dynamics of both species.