Detalhe da pesquisa
1.
Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity.
Pharmacol Rev;
75(3): 463-486, 2023 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36627212
2.
Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress.
BMC Biol;
19(1): 265, 2021 12 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34911556
3.
Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers.
Arch Toxicol;
95(4): 1335-1347, 2021 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33585966
4.
The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury.
Elife;
122023 Jun 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37278519
5.
DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1.
Sci Transl Med;
15(726): eadh9902, 2023 12 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38091406
6.
Pivotal role for two electron reduction in 2,3-dimethoxy-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone metabolism and kinetics in vivo that prevents liver redox stress.
Chem Res Toxicol;
22(4): 717-25, 2009 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19338340
7.
Identification of the Additional Mitochondrial Liabilities of 2-Hydroxyflutamide When Compared With its Parent Compound, Flutamide in HepG2 Cells.
Toxicol Sci;
153(2): 341-51, 2016 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27413113
8.
Effects of mid-respiratory chain inhibition on mitochondrial function in vitro and in vivo.
Toxicol Res (Camb);
5(1): 136-150, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29780577
9.
Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation.
PLoS One;
5(9): e12733, 2010 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20856801