Detalhe da pesquisa
1.
Antimalarial Activity of Artefenomel Against Asexual Parasites and Transmissible Gametocytes During Experimental Blood-Stage Plasmodium vivax Infection.
J Infect Dis;
225(6): 1062-1069, 2022 03 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32479608
2.
New In Vitro Interaction-Parasite Reduction Ratio Assay for Early Derisk in Clinical Development of Antimalarial Combinations.
Antimicrob Agents Chemother;
66(11): e0055622, 2022 11 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36197116
3.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Coadministered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults.
Antimicrob Agents Chemother;
66(1): e0158421, 2022 01 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34694880
4.
Parasite Viability as a Measure of In Vivo Drug Activity in Preclinical and Early Clinical Antimalarial Drug Assessment.
Antimicrob Agents Chemother;
66(7): e0011422, 2022 07 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35727057
5.
Model-Informed Drug Development for Malaria Therapeutics.
Annu Rev Pharmacol Toxicol;
58: 567-582, 2018 01 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28992431
6.
Parasite-Host Dynamics throughout Antimalarial Drug Development Stages Complicate the Translation of Parasite Clearance.
Antimicrob Agents Chemother;
65(4)2021 03 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33526486
7.
A Phase 1, Placebo-controlled, Randomized, Single Ascending Dose Study and a Volunteer Infection Study to Characterize the Safety, Pharmacokinetics, and Antimalarial Activity of the Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048.
Clin Infect Dis;
71(10): e657-e664, 2020 12 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32239164
8.
Safety and parasite clearance of artemisinin-resistant Plasmodium falciparum infection: A pilot and a randomised volunteer infection study in Australia.
PLoS Med;
17(8): e1003203, 2020 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32822347
9.
Safety, Tolerability, Pharmacokinetics, and Antimalarial Activity of the Novel Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048 in Healthy Volunteers.
Antimicrob Agents Chemother;
64(4)2020 03 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31932368
10.
First-in-human clinical trial to assess the safety, tolerability and pharmacokinetics of P218, a novel candidate for malaria chemoprotection.
Br J Clin Pharmacol;
86(6): 1113-1124, 2020 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31925817
11.
DSM265 at 400 Milligrams Clears Asexual Stage Parasites but Not Mature Gametocytes from the Blood of Healthy Subjects Experimentally Infected with Plasmodium falciparum.
Antimicrob Agents Chemother;
63(4)2019 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30858218
12.
A Single-Dose Combination Study with the Experimental Antimalarials Artefenomel and DSM265 To Determine Safety and Antimalarial Activity against Blood-Stage Plasmodium falciparum in Healthy Volunteers.
Antimicrob Agents Chemother;
64(1)2019 12 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31685476
13.
A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation.
J Infect Dis;
217(5): 693-702, 2018 02 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29216395
14.
Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria.
Malar J;
17(1): 402, 2018 Nov 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30384848
15.
New developments in anti-malarial target candidate and product profiles.
Malar J;
16(1): 26, 2017 01 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28086874
16.
Defining the Effectiveness of Antimalarial Chemotherapy: Investigation of the Lag in Parasite Clearance Following Drug Administration.
J Infect Dis;
214(5): 753-61, 2016 09 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27252475
17.
Piperaquine Monotherapy of Drug-Susceptible Plasmodium falciparum Infection Results in Rapid Clearance of Parasitemia but Is Followed by the Appearance of Gametocytemia.
J Infect Dis;
214(1): 105-13, 2016 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27056954
18.
Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development.
Antimicrob Agents Chemother;
60(6): 3669-75, 2016 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27044554
19.
Efficacy of OZ439 (artefenomel) against early Plasmodium falciparum blood-stage malaria infection in healthy volunteers.
J Antimicrob Chemother;
71(9): 2620-7, 2016 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27272721
20.
A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study.
Malar J;
15: 469, 2016 Sep 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27624471