Detalhe da pesquisa
1.
11ß-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature.
Physiol Genomics;
45(1): 47-57, 2013 Jan 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23170035
2.
CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity.
Org Lett;
5(14): 2473-5, 2003 Jul 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12841758
3.
Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice.
Eur J Pharmacol;
650(1): 86-93, 2011 Jan 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20955694
4.
Label-free high-throughput screening via mass spectrometry: a single cystathionine quantitative method for multiple applications.
Assay Drug Dev Technol;
7(5): 495-506, 2009 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19715455
5.
Synthesis and evaluation of CCR5 antagonists containing modified 4-piperidinyl-2-phenyl-1-(phenylsulfonylamino)-butane.
Bioorg Med Chem Lett;
15(4): 977-82, 2005 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15686896
6.
Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties.
Bioorg Med Chem Lett;
15(8): 2129-34, 2005 Apr 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15808483
7.
Combinatorial synthesis of 3-(amidoalkyl) and 3-(aminoalkyl)-2-arylindole derivatives: discovery of potent ligands for a variety of G-protein coupled receptors.
Bioorg Med Chem Lett;
12(1): 93-6, 2002 Jan 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11738581
8.
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains.
Bioorg Med Chem Lett;
14(4): 935-9, 2004 Feb 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15012997
9.
Isolation and structure of antagonists of chemokine receptor (CCR5).
J Nat Prod;
67(6): 1036-8, 2004 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15217290
10.
Syntheses and SAR studies of 4-(heteroarylpiperdin-1-yl-methyl)-pyrrolidin-1-yl-acetic acid antagonists of the human CCR5 chemokine receptor.
Bioorg Med Chem Lett;
14(13): 3419-24, 2004 Jul 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15177445
11.
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: polar functionality and its effect on anti-HIV-1 activity.
Bioorg Med Chem Lett;
12(20): 2997-3000, 2002 Oct 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12270192
12.
CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines.
Bioorg Med Chem Lett;
12(4): 677-9, 2002 Feb 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11844699
13.
1,3,4 Trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains.
Bioorg Med Chem Lett;
13(3): 427-31, 2003 Feb 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12565944
14.
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds.
Bioorg Med Chem Lett;
14(4): 941-5, 2004 Feb 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15012998
15.
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment.
Bioorg Med Chem Lett;
14(4): 947-52, 2004 Feb 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15012999
16.
Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists.
Bioorg Med Chem Lett;
14(13): 3589-93, 2004 Jul 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15177481
17.
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.
Bioorg Med Chem Lett;
12(20): 3001-4, 2002 Oct 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12270193
18.
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains.
Bioorg Med Chem Lett;
13(1): 119-23, 2003 Jan 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12467630