Detalhe da pesquisa
1.
Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich-cultured human hepatocytes.
Can J Physiol Pharmacol;
88(6): 682-91, 2010 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20628435
2.
Effect of steady-state ambrisentan on the pharmacokinetics of a single dose of the oral contraceptive norethindrone (norethisterone) 1 mg/ethinylestradiol 35 microg in healthy subjects: an open-label, single-sequence, single-centre study.
Clin Drug Investig;
30(5): 313-24, 2010.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20384387
3.
Effects of rifampicin (rifampin) on the pharmacokinetics and safety of ambrisentan in healthy subjects: a single-sequence, open-label study.
Clin Drug Investig;
30(12): 875-885, 2010.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20923245
4.
Effect of ketoconazole on the pharmacokinetic profile of ambrisentan.
J Clin Pharmacol;
49(6): 719-24, 2009 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19389876
5.
The pharmacokinetics and pharmacodynamics of warfarin in combination with ambrisentan in healthy volunteers.
Br J Clin Pharmacol;
67(5): 527-34, 2009 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19552747
6.
Pharmacokinetics and safety of ambrisentan in combination with sildenafil in healthy volunteers.
J Clin Pharmacol;
48(12): 1451-9, 2008 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18832294
7.
Pharmacokinetics and safety of cavosonstat (N91115) in healthy and cystic fibrosis adults homozygous for F508DEL-CFTR.
J Cyst Fibros;
16(3): 371-379, 2017 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28209466
8.
Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates.
J Med Chem;
45(2): 304-11, 2002 Jan 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11784135
9.
Automated robotic liquid handling/laser-based nephelometry system for high throughput measurement of kinetic aqueous solubility.
J Pharm Biomed Anal;
36(3): 447-56, 2004 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15522517
10.
No clinically relevant pharmacokinetic and safety interactions of ambrisentan in combination with tadalafil in healthy volunteers.
J Pharm Sci;
98(12): 4962-74, 2009 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19455620
11.
Effects of multiple doses of ambrisentan on the pharmacokinetics of a single dose of digoxin in healthy volunteers.
J Clin Pharmacol;
51(1): 102-6, 2011 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20350954