Detalhe da pesquisa
1.
Absorption, distribution, metabolism and excretion (ADME) of the ALK inhibitor alectinib: results from an absolute bioavailability and mass balance study in healthy subjects.
Xenobiotica;
47(3): 217-229, 2017 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27180975
2.
Characterization of anti-drug antibody responses to the T-cell engaging bispecific antibody cibisatamab to understand the impact on exposure.
Front Immunol;
15: 1406353, 2024.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38881900
3.
CEA-CD3 bispecific antibody cibisatamab with or without atezolizumab in patients with CEA-positive solid tumours: results of two multi-institutional Phase 1 trials.
Nat Commun;
15(1): 4091, 2024 May 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38750034
4.
Characterization of [11C]RO5013853, a novel PET tracer for the glycine transporter type 1 (GlyT1) in humans.
Neuroimage;
75: 282-290, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22155032
5.
Managing the Impact of Immunogenicity in an Era of Immunotherapy: From Bench to Bedside.
J Pharm Sci;
110(7): 2575-2584, 2021 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33812888
6.
Safety and Tolerability of Multiple Ascending Doses of PRX002/RG7935, an Anti-α-Synuclein Monoclonal Antibody, in Patients With Parkinson Disease: A Randomized Clinical Trial.
JAMA Neurol;
75(10): 1206-1214, 2018 10 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29913017
7.
Progress in Prediction and Interpretation of Clinically Relevant Metabolic Drug-Drug Interactions: a Minireview Illustrating Recent Developments and Current Opportunities.
Curr Pharmacol Rep;
3(1): 36-49, 2017.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28261547
8.
Effect of Food and Esomeprazole on the Pharmacokinetics of Alectinib, a Highly Selective ALK Inhibitor, in Healthy Subjects.
Clin Pharmacol Drug Dev;
6(4): 388-397, 2017 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27545320
9.
Clinical Drug-Drug Interactions Through Cytochrome P450 3A (CYP3A) for the Selective ALK Inhibitor Alectinib.
Clin Pharmacol Drug Dev;
6(3): 280-291, 2017 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27545757
10.
Effect of the Wetting Agent Sodium Lauryl Sulfate on the Pharmacokinetics of Alectinib: Results From a Bioequivalence Study in Healthy Subjects.
Clin Pharmacol Drug Dev;
6(3): 266-279, 2017 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27545871
11.
Effects of Cytochrome P450 3A4 Inhibitors-Ketoconazole and Erythromycin-on Bitopertin Pharmacokinetics and Comparison with Physiologically Based Modelling Predictions.
Clin Pharmacokinet;
55(2): 237-47, 2016 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26341813
12.
Combining 'Bottom-Up' and 'Top-Down' Methods to Assess Ethnic Difference in Clearance: Bitopertin as an Example.
Clin Pharmacokinet;
55(7): 823-832, 2016 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26715215
13.
Effects of the glycine reuptake inhibitors bitopertin and RG7118 on glycine in cerebrospinal fluid: results of two proofs of mechanism studies in healthy volunteers.
Psychopharmacology (Berl);
233(13): 2429-39, 2016 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27178435
14.
Quality markers of drug information on the Internet: an evaluation of sites about St. John's wort.
Am J Med;
113(9): 740-5, 2002 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12517364
15.
A drug database model as a central element for computer-supported dose adjustment within a CPOE system.
J Am Med Inform Assoc;
11(5): 427-32, 2004.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15187062
16.
Simultaneous determination of hypericin and hyperforin in human plasma with liquid chromatography-tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci;
813(1-2): 27-33, 2004 Dec 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15556512
17.
Highly sensitive determination of saquinavir in biological samples using liquid chromatography-tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci;
784(2): 233-42, 2003 Feb 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12505771
18.
Physiologically based absorption modelling to predict the impact of drug properties on pharmacokinetics of bitopertin.
AAPS J;
16(5): 1077-84, 2014 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24970349
19.
Effect of bitopertin, a glycine reuptake inhibitor, on negative symptoms of schizophrenia: a randomized, double-blind, proof-of-concept study.
JAMA Psychiatry;
71(6): 637-46, 2014 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24696094
20.
Physiologically based pharmacokinetic modelling to predict single- and multiple-dose human pharmacokinetics of bitopertin.
Clin Pharmacokinet;
52(8): 673-83, 2013 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23591780