Detalhe da pesquisa
1.
A Phase I, First-in-Human, Healthy Volunteer Study to Investigate the Safety, Tolerability, and Pharmacokinetics of CVN424, a Novel G Protein-Coupled Receptor 6 Inverse Agonist for Parkinson's Disease.
J Pharmacol Exp Ther;
381(1): 33-41, 2022 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35110393
2.
Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor.
Bioorg Med Chem Lett;
29(1): 83-88, 2019 01 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30463802
3.
Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington's Disease.
ACS Med Chem Lett;
12(3): 380-388, 2021 Mar 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33738065
4.
Structure-Based Exploration of Selectivity for ATM Inhibitors in Huntington's Disease.
J Med Chem;
64(8): 5018-5036, 2021 04 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33783225
5.
Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain.
Bioorg Med Chem Lett;
20(15): 4683-8, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20566291
6.
The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor.
Bioorg Med Chem Lett;
19(22): 6452-8, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19804969
7.
Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease Models.
J Med Chem;
62(6): 2988-3008, 2019 03 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30840447
8.
The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor.
Bioorg Med Chem Lett;
18(24): 6429-36, 2008 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19006669
9.
Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors.
ACS Med Chem Lett;
7(1): 34-9, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26819662
10.
Noradrenergic changes, aggressive behavior, and cognition in patients with dementia.
Biol Psychiatry;
51(5): 407-16, 2002 Mar 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11904135
11.
Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease.
J Med Chem;
56(24): 9934-54, 2013 Dec 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24261862
12.
Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate.
J Med Chem;
52(4): 1180-9, 2009 Feb 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19191554