Detalhe da pesquisa
1.
Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics.
Nucleic Acids Res;
51(4): 1583-1599, 2023 02 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36727438
2.
Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs.
Mol Cell Proteomics;
18(3): 408-422, 2019 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30482847
3.
Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6.
J Cell Sci;
131(12)2018 06 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29848659
4.
Biocompatible Chemotherapy for Leukemia by Acid-Cleavable, PEGylated FTY720.
Bioconjug Chem;
31(3): 673-684, 2020 03 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31986014
5.
Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A.
Bioorg Med Chem Lett;
29(18): 2681-2685, 2019 09 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31383588
6.
Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell death.
Bioorg Med Chem;
24(18): 4390-4397, 2016 09 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27475534
7.
Targeting cancer metabolism at the plasma membrane by limiting amino acid access through SLC6A14.
Biochem J;
470(3): e17-9, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26341486
8.
Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines.
ACS Med Chem Lett;
11(5): 686-690, 2020 May 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32435371
9.
In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways.
Eur J Med Chem;
159: 217-242, 2018 Nov 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30292898
10.
Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo.
ACS Chem Biol;
11(2): 409-14, 2016 Feb 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26653336
11.
Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.
J Clin Invest;
126(11): 4088-4102, 2016 11 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27669461
12.
Nutrient transporters: the Achilles' heel of anabolism.
Trends Endocrinol Metab;
24(4): 200-8, 2013 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23402769
13.
Design, Synthesis, and Anti-leukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya).
ACS Med Chem Lett;
4(10)2013 Oct 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24273632