Detalhe da pesquisa
1.
Targeting DNA topoisomerase IIα (TOP2A) in the hypoxic tumour microenvironment using unidirectional hypoxia-activated prodrugs (uHAPs).
IUBMB Life;
75(1): 40-54, 2023 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35499745
2.
The unidirectional hypoxia-activated prodrug OCT1002 inhibits growth and vascular development in castrate-resistant prostate tumors.
Prostate;
77(15): 1539-1547, 2017 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28944496
3.
Nitric Oxide Up-Regulates RUNX2 in LNCaP Prostate Tumours: Implications for Tumour Growth In Vitro and In Vivo.
J Cell Physiol;
231(2): 473-82, 2016 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26189652
4.
Comet assay measures of DNA damage are predictive of bladder cancer cell treatment sensitivity in vitro and outcome in vivo.
Int J Cancer;
134(5): 1102-11, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23959905
5.
Androgen deprivation results in time-dependent hypoxia in LNCaP prostate tumours: informed scheduling of the bioreductive drug AQ4N improves treatment response.
Int J Cancer;
132(6): 1323-32, 2013 Mar 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22915157
6.
Cytochrome P450 1B1 mRNA untranslated regions interact to inhibit protein translation.
Mol Carcinog;
49(2): 190-9, 2010 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19908239
7.
Cytochrome P450 1B1 expression in rat esophageal tumorigenesis promoted by gastric and duodenal reflux.
Mol Carcinog;
48(2): 110-7, 2009 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18618592
8.
Evaluation of the antiangiogenic potential of AQ4N.
Clin Cancer Res;
14(5): 1502-9, 2008 Mar 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18316575
9.
Hypoxia selects for androgen independent LNCaP cells with a more malignant geno- and phenotype.
Int J Cancer;
123(4): 760-8, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18512241
10.
Potential use of the comet assay in the clinical management of cancer.
Mutagenesis;
23(3): 183-90, 2008 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18256034
11.
Investigation of pericytes, hypoxia, and vascularity in bladder tumors: association with clinical outcomes.
Oncol Res;
17(3): 93-101, 2008.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18669161
12.
Pericytes influence endothelial cell growth characteristics: role of plasminogen activator inhibitor type 1 (PAI-1).
Cardiovasc Res;
69(1): 207-17, 2006 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16165110
13.
Targeting Hypoxic Prostate Tumors Using the Novel Hypoxia-Activated Prodrug OCT1002 Inhibits Expression of Genes Associated with Malignant Progression.
Clin Cancer Res;
23(7): 1797-1808, 2017 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27697998
14.
Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis.
Gene;
577(2): 109-18, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26657039
15.
Modification of the alkaline Comet assay to allow simultaneous evaluation of mitomycin C-induced DNA cross-link damage and repair of specific DNA sequences in RT4 cells.
DNA Repair (Amst);
2(8): 879-90, 2003 Aug 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12893084
16.
Radiotherapy for benign disease; assessing the risk of radiation-induced cancer following exposure to intermediate dose radiation.
Br J Radiol;
88(1056): 20150405, 2015.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26462717
17.
Bioreductive GDEPT using cytochrome P450 3A4 in combination with AQ4N.
Cancer Gene Ther;
10(1): 40-8, 2003 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12489027
18.
Gene-directed enzyme prodrug therapy: a current assessment.
Curr Opin Mol Ther;
6(4): 421-35, 2004 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15468601
19.
Use of the comet-FISH assay to demonstrate repair of the TP53 gene region in two human bladder carcinoma cell lines.
Radiat Res;
159(1): 49-56, 2003 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12492368
20.
Use of the comet-FISH assay to compare DNA damage and repair in p53 and hTERT genes following ionizing radiation.
PLoS One;
7(11): e49364, 2012.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23145163