Detalhe da pesquisa
1.
Identification and Strategies to Mitigate High Total Clearance of Benzylamine-Substituted Biphenyl Ring Systems.
Mol Pharm;
19(7): 2115-2132, 2022 07 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35533086
2.
Transition-Metal-Mediated Chemo- and Stereoselective Total Synthesis of (-)-Galanthamine.
J Org Chem;
87(2): 1325-1334, 2022 01 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35007075
3.
Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
Bioorg Med Chem Lett;
29(12): 1522-1531, 2019 06 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30981576
4.
Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase ß isoform.
Bioorg Med Chem Lett;
23(9): 2606-13, 2013 May 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23540645
5.
A large geometric distortion in the first photointermediate of rhodopsin, determined by double-quantum solid-state NMR.
J Biomol NMR;
53(3): 247-56, 2012 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22639195
6.
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer.
J Med Chem;
64(16): 11841-11856, 2021 08 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34251202
7.
Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy.
J Med Chem;
64(18): 13524-13539, 2021 09 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34478292
8.
Towards an interpretation of 13C chemical shifts in bathorhodopsin, a functional intermediate of a G-protein coupled receptor.
Biochim Biophys Acta;
1788(6): 1350-7, 2009 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19265671
9.
Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer.
ACS Med Chem Lett;
11(6): 1342-1347, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32551022
10.
Light penetration and photoisomerization in rhodopsin studied by numerical simulations and double-quantum solid-state NMR spectroscopy.
J Am Chem Soc;
131(17): 6133-40, 2009 May 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19354207
11.
Double-quantum 13C nuclear magnetic resonance of bathorhodopsin, the first photointermediate in mammalian vision.
J Am Chem Soc;
130(32): 10490-1, 2008 Aug 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18642911
12.
Stereocontrolled synthesis of (-)-galanthamine.
Org Lett;
9(10): 1867-9, 2007 May 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17429978
13.
Analytical theory of gamma-encoded double-quantum recoupling sequences in solid-state nuclear magnetic resonance.
J Magn Reson;
186(1): 65-74, 2007 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17303455
14.
The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).
J Med Chem;
59(3): 985-1002, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26741947
15.
Accurate measurements of 13C-13C J-couplings in the rhodopsin chromophore by double-quantum solid-state NMR spectroscopy.
J Am Chem Soc;
128(12): 3878-9, 2006 Mar 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16551073