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The measurement of glucose concentration is a fundamental daily care for diabetes patients, and therefore, its detection with accuracy is of prime importance in the field of health care. In this study, the fabrication of an electrochemical sensor for glucose sensing was successfully designed. The electrode material was fabricated using polyaniline and systematically characterized using scanning electron microscopy, high-resolution transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and UV-visible spectroscopy. The polyaniline nanofiber-modified electrode showed excellent detection ability for glucose with a linear range of 10 µM to 1 mM and a detection limit of 10.6 µM. The stability of the same electrode was tested for 7 days. The electrode shows high sensitivity for glucose detection in the presence of interferences. The polyaniline-modified electrode does not affect the presence of interferences and has a low detection limit. It is also cost-effective and does not require complex sample preparation steps. This makes it a potential tool for glucose detection in pharmacy and medical diagnostics.
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Compostos de Anilina , Técnicas Biossensoriais , Técnicas Eletroquímicas , Eletrodos , Glucose , Nanofibras , Compostos de Anilina/química , Nanofibras/química , Técnicas Eletroquímicas/métodos , Glucose/análise , Glucose/química , Técnicas Biossensoriais/métodos , Limite de Detecção , Humanos , Espectroscopia de Infravermelho com Transformada de FourierRESUMO
In this paper, a highly sensitive graphene-based multiple-layer (BK7/Au/PtSe2/Graphene) coated surface plasmon resonance (SPR) biosensor is proposed for the rapid detection of the novel Coronavirus (COVID-19). The proposed sensor was modeled on the basis of the total internal reflection (TIR) technique for real-time detection of ligand-analyte immobilization in the sensing region. The refractive index (RI) of the sensing region is changed due to the interaction of different concentrations of the ligand-analyte, thus impacting surface plasmon polaritons (SPPs) excitation of the multi-layer sensor interface. The performance of the proposed sensor was numerically investigated by using the transfer matrix method (TMM) and the finite-difference time-domain (FDTD) method. The proposed SPR biosensor provides fast and accurate early-stage diagnosis of the COVID-19 virus, which is crucial in limiting the spread of the pandemic. In addition, the performance of the proposed sensor was investigated numerically with different ligand-analytes: (i) the monoclonal antibodies (mAbs) as ligand and the COVID-19 virus spike receptor-binding domain (RBD) as analyte, (ii) the virus spike RBD as ligand and the virus anti-spike protein (IgM, IgG) as analyte and (iii) the specific probe as ligand and the COVID-19 virus single-standard ribonucleic acid (RNA) as analyte. After the investigation, the sensitivity of the proposed sensor was found to provide 183.33°/refractive index unit (RIU) in SPR angle (θSPR) and 833.33THz/RIU in SPR frequency (SPRF) for detection of the COVID-19 virus spike RBD; the sensitivity obtained 153.85°/RIU in SPR angle and 726.50THz/RIU in SPRF for detection of the anti-spike protein, and finally, the sensitivity obtained 140.35°/RIU in SPR angle and 500THz/RIU in SPRF for detection of viral RNA. It was observed that whole virus spike RBD detection sensitivity is higher than that of the other two detection processes. Highly sensitive two-dimensional (2D) materials were used to achieve significant enhancement in the Goos-Hänchen (GH) shift detection sensitivity and plasmonic properties of the conventional SPR sensor. The proposed sensor successfully senses the COVID-19 virus and offers additional (1 + 0.55) × L times sensitivity owing to the added graphene layers. Besides, the performance of the proposed sensor was analyzed based on detection accuracy (DA), the figure of merit (FOM), signal-noise ratio (SNR), and quality factor (QF). Based on its performance analysis, it is expected that the proposed sensor may reduce lengthy procedures, false positive results, and clinical costs, compared to traditional sensors. The performance of the proposed sensor model was checked using the TMM algorithm and validated by the FDTD technique.
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Técnicas Biossensoriais , COVID-19 , Grafite , Humanos , SARS-CoV-2 , Ressonância de Plasmônio de SuperfícieRESUMO
Through a wireless capsule endoscope (WCE) fitted with a miniature camera (about an inch), this study aims to examine the role of wireless capsule endoscopy (WCE) in the diagnosis, monitoring, and evaluation of GI (gastrointestinal) disorders. In a wearable belt recorder, a capsule travels through the digestive tract and takes pictures. It attempts to find tiny components that can be used to enhance the WCE. To accomplish this, we followed the steps below: Researching current capsule endoscopy through databases, designing and simulating the device using computers, implanting the system and finding tiny components compatible with capsule size, testing the system and eliminating noise and other problems, and analyzing the results. In the present study, it was shown that a spherical WCE shaper and a smaller WCE with a size of 13.5 diameter, a high resolution, and a high frame rate (8-32 fps) could help patients with pains due to the traditional capsules and provide more accurate pictures as well as prolong the battery life. In addition, the capsule can also be used to reconstruct 3D images. Simulation experiments showed that spherical endoscopic devices are more advantageous than commercial capsule-shaped endoscopic devices for wireless applications. We found that the sphere's velocity through the fluid was greater than the capsule's.
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We report the synthesis of Fe3O4/graphene (Fe3O4/Gr) nanocomposite for highly selective and highly sensitive peroxide sensor application. The nanocomposites were produced by a modified co-precipitation method. Further, structural, chemical, and morphological characterization of the Fe3O4/Gr was investigated by standard characterization techniques, such as X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscope (TEM) and high-resolution TEM (HRTEM), Fourier transform infrared (FTIR), and X-ray photoelectron spectroscopy (XPS). The average crystal size of Fe3O4 nanoparticles was calculated as 14.5 nm. Moreover, nanocomposite (Fe3O4/Gr) was employed to fabricate the flexible electrode using polymeric carbon fiber cloth or carbon cloth (pCFC or CC) as support. The electrochemical performance of as-fabricated Fe3O4/Gr/CC was evaluated toward H2O2 with excellent electrocatalytic activity. It was found that Fe3O4/Gr/CC-based electrodes show a good linear range, high sensitivity, and a low detection limit for H2O2 detection. The linear range for the optimized sensor was found to be in the range of 10-110 µM and limit of detection was calculated as 4.79 µM with a sensitivity of 0.037 µA µM-1 cm-2. The cost-effective materials used in this work as compared to noble metals provide satisfactory results. As well as showing high stability, the proposed biosensor is also highly reproducible.
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This manuscript proposes a hybrid method for landing trajectory generation of unmanned lunar mission. The proposed hybrid control scheme is the joint execution of the human urbanization algorithm (HUA) and political optimizer (PO) with radial basis functional neural network (RBFNN); hence it is named as HUA-PORFNN method. The HUA is a metaheuristic method, and it is used to solve several optimization issues and several nature-inspired methods to enhance the convergence speed with quality. On the other hand, multiple-phased political processes inspire the PO. The work aims to guide the lander with minimal fuel consumption from the initial to the final stage, thus minimizing the lunar soft landing issues based on the given cost of operation. Here, the HUAPO method is implemented to overcome thrust discontinuities, checkpoint constraints are suggested for connecting multi-landing phases, angular attitude rate is modeled to obtain radical change rid, and safeguards are enforced to deflect collision along with obstacles. Moreover, first, the issues have been resolved according to the proposed HUAPO method. Here, energy trajectories with 3 terminal processes are deemed. Additionally, the proposed HUAPO method is executed on MATLAB/Simulink site, and the performance of the proposed method is compared with other methods.
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Algoritmos , Redes Neurais de Computação , HumanosRESUMO
A combination of environmental conditions may cause skin illness everywhere on the earth, and it is one of the most dangerous diseases that can develop as a result. A major goal in the selection of characteristics is to produce predictions about skin disease instances in connection with influencing variables, which is one of the most important tasks. As a consequence of the widespread usage of sensors, the amount of data collected in the health industry is disproportionately large when compared to data collected in other sectors. In the past, researchers have used a variety of machine learning algorithms to determine the relationship between illnesses and other disorders. Forecasting is a procedure that involves many steps, the most important of which are the preprocessing of any scenario and the selection of forecasting features. A major disadvantage of doing business in the health industry is a lack of data availability, which is particularly problematic when data is provided in an unstructured format. Filling in missing numbers and converting between various types of data take somewhat more than 70% of the total time. When dealing with missing data in machine learning applications, the mean, average, and median, as well as the stand mechanism, may all be employed to solve the problem. Previous research has shown that the characteristics chosen for a model's overall performance may have an influence on the overall performance of the model's overall performance. One of the primary goals of this study is to develop an intelligent algorithm for identifying relevant traits in models while simultaneously eliminating nonsignificant attributes that have an impact on model performance. To present a full view of the data, artificial intelligence techniques such as SVM, decision tree, and logistic regression models were used in conjunction with three separate feature combination methodologies, each of which was developed independently. As a consequence of this, their accuracy, F-measure, and precision are all raised by a factor of ten, respectively. We then have a list of the most important features, together with the weights that have been allocated to each of them.
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Inteligência Artificial , Dermatopatias , Algoritmos , Humanos , Modelos Logísticos , Aprendizado de MáquinaRESUMO
Coronavirus 2019 (COVID-19) has become a pandemic. The seriousness of COVID-19 can be realized from the number of victims worldwide and large number of deaths. This paper presents an efficient deep semantic segmentation network (DeepLabv3Plus). Initially, the dynamic adaptive histogram equalization is utilized to enhance the images. Data augmentation techniques are then used to augment the enhanced images. The second stage builds a custom convolutional neural network model using several pretrained ImageNet models and compares them to repeatedly trim the best-performing models to reduce complexity and improve memory efficiency. Several experiments were done using different techniques and parameters. Furthermore, the proposed model achieved an average accuracy of 99.6% and an area under the curve of 0.996 in the COVID-19 detection. This paper will discuss how to train a customized smart convolutional neural network using various parameters on a set of chest X-rays with an accuracy of 99.6%.
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COVID-19 , Aprendizado Profundo , Pneumonia , Inteligência Artificial , COVID-19/diagnóstico por imagem , Humanos , SARS-CoV-2 , SemânticaRESUMO
The capacity to carry out one's regular tasks is affected to varying degrees by hearing difficulties. Poorer understanding, slower learning, and an overall reduction in efficiency in academic endeavours are just a few of the negative impacts of hearing impairments on children's performance, which may range from mild to severe. A significant factor in determining whether or not there will be a decrease in performance is the kind and source of impairment. Research has shown that the Artificial Neural Network technique is capable of modelling both linear and nonlinear solution surfaces in a trustworthy way, as demonstrated in previous studies. To improve the precision with which hearing impairment challenges are diagnosed, a neural network backpropagation approach has been developed with the purpose of fine-tuning the diagnostic process. In particular, it highlights the vital role performed by medical informatics in supporting doctors in the identification of diseases as well as the formulation of suitable choices via the use of data management and knowledge discovery. As part of the intelligent control method, it is proposed in this research to construct a Histogram Equalization (HE)-based Adaptive Center-Weighted Median (ACWM) filter, which is then used to segment/detect the OM in tympanic membrane images using different segmentation methods in order to minimise noise and improve the image quality. A tympanic membrane dataset, which is freely accessible, was used in all experiments.
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Algoritmos , Otite , Criança , Humanos , Redes Neurais de ComputaçãoRESUMO
An adaptive fuzzy sliding control (AFSMC) approach is adopted in this paper to address the problem of angular position control and vibration suppression of rotary flexible joint systems. AFSMC consists of fuzzy-based singleton control action and switching control law. By adjusting fuzzy parameters with the self-learning ability to discard system nonlinearities and uncertainties, singleton control based on fuzzy approximation theory can estimate the perfect control law of feedback linearization. To enhance robustness, an additional switching control law is incorporated to reduce the approximation error between the derived singleton control action and the perfect control law of feedback linearization. AFSMC's closed-loop stability will be demonstrated via sliding surface and Lyapunov function analysis of error function. In order to demonstrate the effectiveness of the AFSMC in tracking performance as well as its ability to respond to model uncertainties and external perturbations, simulations are carried out using Simulink and Matlab in order to demonstrate how well it adapts to these situations. Based on these results, it can be concluded that the AFSMC performs satisfactorily in terms of tracking.
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Retroalimentação , IncertezaRESUMO
This paper presents the application of adaptive fuzzy sliding mode control (AFSMC) for the respiratory system to assist the patients facing difficulty in breathing. The ventilator system consists of a blower-hose-patient system and patient's lung model with nonlinear lung compliance. The AFSMC is based on two components: singleton control action and a discontinuous term. The singleton control action is based on fuzzy logic with adjustable tuning parameters to approximate the perfect feedback linearization control. The switching control law based on the sliding mode principle aims to minimize the estimation error between approximated single fuzzy control action and perfect feedback linearization control. The proposed control strategy manipulated the airway flow delivered by the ventilator such that the peak pressure will remain under critical values in presence of unknown patient-hose-leak parameters and patient breathing effort. The closed-loop stability of AFSMC will be proven in the sense of Lyapunov. For comparative analysis, classical PID and sliding mode controllers are also designed and implemented for mechanical ventilation problems. For performance analysis, numerical simulations were performed on a mechanical ventilator simulator. Simulation results reveal that the proposed controller demonstrates better tracking of targeted airway pressure compared with its counterparts in terms of faster convergence, less overshoot, and small tracking error. Hence, the proposed controller provides useful insight for its application to real-world scenarios.
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Algoritmos , Lógica Fuzzy , Simulação por Computador , Retroalimentação , Humanos , Ventiladores MecânicosRESUMO
This paper presents the implementation of a fuzzy proportional integral derivative (FPID) control design to track the airway pressure during the mechanical ventilation process. A respiratory system is modeled as a combination of a blower-hose-patient system and a single compartmental lung system with nonlinear lung compliance. For comparison purposes, the classical PID controller is also designed and simulated on the same system. According to the proposed control strategy, the ventilator will provide airway flow that maintains the peak pressure below critical levels when there are unknown parameters of the patient's hose leak and patient breathing effort. Results show that FPID is a better controller in the sense of quicker response, lower overshoot, and smaller tracking error. This provides valuable insight for the application of the proposed controller.
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Respiração Artificial , Respiração , Simulação por Computador , Humanos , Sistema RespiratórioRESUMO
The world has been facing the COVID-19 pandemic since December 2019. Timely and efficient diagnosis of COVID-19 suspected patients plays a significant role in medical treatment. The deep transfer learning-based automated COVID-19 diagnosis on chest X-ray is required to counter the COVID-19 outbreak. This work proposes a real-time Internet of Things (IoT) framework for early diagnosis of suspected COVID-19 patients by using ensemble deep transfer learning. The proposed framework offers real-time communication and diagnosis of COVID-19 suspected cases. The proposed IoT framework ensembles four deep learning models such as InceptionResNetV2, ResNet152V2, VGG16, and DenseNet201. The medical sensors are utilized to obtain the chest X-ray modalities and diagnose the infection by using the deep ensemble model stored on the cloud server. The proposed deep ensemble model is compared with six well-known transfer learning models over the chest X-ray dataset. Comparative analysis revealed that the proposed model can help radiologists to efficiently and timely diagnose the COVID-19 suspected patients.
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Inteligência Artificial , Teste para COVID-19 , COVID-19/diagnóstico , Internet das Coisas , SARS-CoV-2 , Brasil , China , Simulação por Computador , Sistemas Computacionais , Bases de Dados Factuais , Aprendizado Profundo , Diagnóstico por Computador , Humanos , Reconhecimento Automatizado de Padrão , Radiografia Torácica , Estados Unidos , Raios XRESUMO
During the past two decades, many remote sensing image fusion techniques have been designed to improve the spatial resolution of the low-spatial-resolution multispectral bands. The main objective is fuse the low-resolution multispectral (MS) image and the high-spatial-resolution panchromatic (PAN) image to obtain a fused image having high spatial and spectral information. Recently, many artificial intelligence-based deep learning models have been designed to fuse the remote sensing images. But these models do not consider the inherent image distribution difference between MS and PAN images. Therefore, the obtained fused images may suffer from gradient and color distortion problems. To overcome these problems, in this paper, an efficient artificial intelligence-based deep transfer learning model is proposed. Inception-ResNet-v2 model is improved by using a color-aware perceptual loss (CPL). The obtained fused images are further improved by using gradient channel prior as a postprocessing step. Gradient channel prior is used to preserve the color and gradient information. Extensive experiments are carried out by considering the benchmark datasets. Performance analysis shows that the proposed model can efficiently preserve color and gradient information in the fused remote sensing images than the existing models.
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Inteligência Artificial , Tecnologia de Sensoriamento RemotoRESUMO
In the technology driven era, robot assisted surgery is gradually emerging as a revolutionized surgical procedure over traditional laparoscopic method. Despite the concerns about robotic surgery for minimally invasive surgical procedures, robotized surgical arms have been used in many hospitals. Certain surgical procedures require removal of a segment of an organ or body part like excision biopsy, linear thin layer of soft tissue, triangular mass, and tangential excision in burn management, where shaving-off at an angle of the tissue layer to be removed. For such minimally invasive procedures, we have designed a surgical arm governed by a rotary flexible joint. The surgical arm has a medical grade scalpel in its one end and the other end is connected to a D.C. servo motor. The motion of the surgical arm is controlled by the newly designed non-integer order controller. We have experimentally demonstrated the functioning of the surgical arm by ablating the tissue in-vitro. Our surgical robotic arm is cost effective, high precision and free from potential human errors.