1.
J Infect Dis
; 219(1): 26-30, 2019 01 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30113672
RESUMO
The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection.
Assuntos
Anticorpos Neutralizantes/sangue , Anticorpos Antivirais/sangue , Dengue/sangue , Síndrome de Guillain-Barré/sangue , Infecção por Zika virus/sangue , Adulto , Estudos de Casos e Controles , Colômbia/epidemiologia , Dengue/complicações , Dengue/imunologia , Vírus da Dengue/isolamento & purificação , Feminino , Síndrome de Guillain-Barré/complicações , Síndrome de Guillain-Barré/virologia , Humanos , Masculino , Pessoa de Meia-Idade , Zika virus/isolamento & purificação , Infecção por Zika virus/complicações , Infecção por Zika virus/imunologia
2.
Emerg Microbes Infect
; 7(1): 148, 2018 Aug 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30131486