Copper-Catalyzed Regio- and Stereoselective Sulfonylation of Alkynyl Imines with Sulfonyl Hydrazides: Access to (E)-ß-Sulfonyl Enones.

A copper-catalyzed sulfonylation of alkynyl imines with sulfonyl hydrazides has been developed, which exhibited excellent regio- and stereoselectivity and furnished a series of (E)-ß-sulfonyl enones in moderate to good yields. Mechanistic studies suggest that this strategy goes through a radical process.

Efficient construction of five-membered aromatic and nonaromatic heterocycles from 1,6-enynes by a palladium-catalyzed domino coupling/cycloisomerization process.

General and efficient methods for the construction of five-membered aromatic and nonaromatic heterocycles by palladium-catalyzed coupling/cycloisomerization of 1,6-enynes and aryl halides have been developed. Results indicate that substituents at the terminus of the alkynes have a significant effect on the selective formation of the products.

3-Phenyl-1,5-di-2-thienylpentane-1,5-dione.

The asymmetric unit of the title compound, C(19)H(16)O(2)S(2), contains two independent mol-ecules with slightly different conformations. In the crystal structure, weak inter-molecular C-H⋯O hydrogen bonds [C⋯O = 3.279 (15) and 3.407 (16) Å] link the mol-ecules into chains extended along the c axis.

1,1'-[o-Phenyl-enebis(nitrilo-methyl-idyne)]di-2-naphthol ethanol hemisolvate.

The asymmetric unit of the title compound, C(28)H(20)N(2)O(2)·0.5C(2)H(5)OH, contains two independent mol-ecules of 1,1'-[o-phenyl-enebis(nitrilo-methyl-idyne)]di-2-naphthol, denoted A and B, and one ethanol solvent mol-ecule. The hydr-oxy groups are involved in intra-molecular O-H⋯N hydrogen bonds influencing the mol-ecular conformations, which are slightly different in mol-ecules A and B, where the two bicyclic systems form dihedral angles of 51.93 (9) and 58.52 (9)°, respectively. In the crystal structure, a number of short inter-molecular C⋯C contacts with distances of less than 3.5 Šsuggest the existence of π-π inter-actions, which contribute to the stability of the crystal packing.

Asymmetric synthesis of planar chiral ferrocenes by enantioselective intramolecular C-H arylation of N-(2-haloaryl)ferrocenecarboxamides.

The palladium-catalyzed intramolecular C-H arylation reaction of N-(2-bromoaryl)ferrocenecarboxamides furnishes planar chiral ferrocene derivatives. TADDOL-derived phosphoramide ligands induce enantioselectivities ranging from 91:9 to 98:2 er.