Detalhe da pesquisa
1.
Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease.
Immunity;
56(9): 2121-2136.e6, 2023 09 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37659412
2.
INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease.
Alzheimers Dement;
19(6): 2528-2537, 2023 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36524682
3.
Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation.
Annu Rev Pharmacol Toxicol;
59: 237-261, 2019 01 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30208281
4.
INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia.
Neurobiol Dis;
153: 105303, 2021 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33631273
5.
The mevalonate pathway in neurons: It's not just about cholesterol.
Exp Cell Res;
360(1): 55-60, 2017 11 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28232115
6.
Therapeutic potential of nuclear receptor agonists in Alzheimer's disease.
J Lipid Res;
58(10): 1937-1949, 2017 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28264880
7.
Cholesterol 24-hydroxylase: Brain cholesterol metabolism and beyond.
Biochim Biophys Acta;
1861(12 Pt A): 1911-1920, 2016 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27663182
8.
Cholesterol redistribution triggered by CYP46A1 gene therapy improves major hallmarks of Niemann-Pick type C disease but is not sufficient to halt neurodegeneration.
Biochim Biophys Acta Mol Basis Dis;
1870(3): 166993, 2024 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38142760
9.
Characterization of new G protein-coupled adenine receptors in mouse and hamster.
Purinergic Signal;
9(3): 415-26, 2013 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23608776
10.
TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation.
Genome Med;
15(1): 11, 2023 02 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36805764
11.
Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway.
J Lipid Res;
53(9): 1910-9, 2012 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22693257
12.
Neuronal differentiation alters the ratio of Sp transcription factors recruited to the CYP46A1 promoter.
J Neurochem;
120(2): 220-9, 2012 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22060190
13.
PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer's disease.
Genome Med;
14(1): 17, 2022 02 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35180881
14.
The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease.
Sci Transl Med;
14(637): eabl7634, 2022 03 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35320002
15.
CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer's disease.
Mol Neurodegener;
17(1): 47, 2022 06 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35764973
16.
TREM2 splicing emerges as crucial aspect to understand TREM2 biology.
J Leukoc Biol;
110(5): 827-828, 2021 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34312904
17.
Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice.
Mol Neurodegener;
15(1): 62, 2020 10 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33115519
18.
The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.
Mol Neurodegener;
13(1): 29, 2018 06 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29859094
19.
Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk.
Sci Rep;
6: 30928, 2016 08 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27491694
20.
Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells.
Mol Neurobiol;
51(3): 1489-503, 2015.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25084760