Detalhe da pesquisa
1.
A phase Ib study of adavosertib, a selective Wee1 inhibitor, in patients with locally advanced or metastatic solid tumors.
Invest New Drugs;
41(3): 493-502, 2023 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37171722
2.
Longitudinal Circulating Tumor DNA Modeling to Predict Disease Progression in First-Line Mutant Epidermal Growth Factor Receptor Non-Small Cell Lung Cancer.
Clin Pharmacol Ther;
115(2): 349-360, 2024 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38010260
3.
Development of a multiscale mechanistic modeling framework integrating differential cellular kinetics of CAR T-cell subsets and immunophenotypes in cancer patients.
CPT Pharmacometrics Syst Pharmacol;
12(9): 1285-1304, 2023 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37448297
4.
Phase I study to assess the effect of adavosertib (AZD1775) on the pharmacokinetics of substrates of CYP1A2, CYP2C19, and CYP3A in patients with advanced solid tumors.
Cancer Chemother Pharmacol;
92(3): 193-203, 2023 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37394627
5.
Adavosertib (AZD1775) does not prolong the QTc interval in patients with advanced solid tumors: a phase I open-label study.
Cancer Chemother Pharmacol;
92(2): 141-150, 2023 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37368100
6.
Assessment of the impact of CYP3A polymorphisms on the formation of α-hydroxytamoxifen and N-desmethyltamoxifen in human liver microsomes.
Drug Metab Dispos;
40(2): 389-96, 2012 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22096084
7.
Quantification of human hepatocyte cytochrome P450 enzymes and transporters induced by HIV protease inhibitors using newly validated LC-MS/MS cocktail assays and RT-PCR.
Biopharm Drug Dispos;
33(4): 207-17, 2012 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22498895
8.
Association between immune-mediated adverse events and efficacy in metastatic non-small-cell lung cancer patients treated with durvalumab and tremelimumab.
Front Immunol;
13: 1026964, 2022.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36405729
9.
Adavosertib with Chemotherapy in Patients with Primary Platinum-Resistant Ovarian, Fallopian Tube, or Peritoneal Cancer: An Open-Label, Four-Arm, Phase II Study.
Clin Cancer Res;
28(1): 36-44, 2022 01 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34645648
10.
Safety, Pharmacokinetics, and Clinical Activity of Adavosertib in Combination with Chemotherapy in Asian Patients with Advanced Solid Tumors: Phase Ib Study.
Target Oncol;
15(1): 75-84, 2020 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32034630
11.
Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors.
Drug Metab Dispos;
36(6): 1172-80, 2008 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18332086
12.
A Phase I Clinical Trial of AZD1775 in Combination with Neoadjuvant Weekly Docetaxel and Cisplatin before Definitive Therapy in Head and Neck Squamous Cell Carcinoma.
Clin Cancer Res;
24(12): 2740-2748, 2018 06 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29535125
13.
Population pharmacokinetic-pharmacodynamic modelling of 24-h diastolic ambulatory blood pressure changes mediated by axitinib in patients with metastatic renal cell carcinoma.
Clin Pharmacokinet;
54(4): 397-407, 2015 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25343945
14.
The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects.
Eur J Endocrinol;
168(6): 821-8, 2013 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23482590
15.
Impact of ritonavir, atazanavir and their combination on the CYP3A4 induction potential of efavirenz in primary human hepatocytes.
Drug Metab Lett;
4(1): 45-50, 2010 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20201776