Detalhe da pesquisa
1.
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.
Diabetologia;
61(3): 641-657, 2018 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29185012
2.
Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies.
Proc Natl Acad Sci U S A;
112(7): E667-76, 2015 Feb 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25646459
3.
A Spatial Model of Insulin-Granule Dynamics in Pancreatic ß-Cells.
Traffic;
16(8): 797-813, 2015 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25809669
4.
A 4D view on insulin secretory granule turnover in the ß-cell.
Diabetes Obes Metab;
19 Suppl 1: 107-114, 2017 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28880479
5.
The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance.
J Immunol;
191(8): 4367-74, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24043887
6.
Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5.
Nat Cell Biol;
8(5): 435-45, 2006 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16622421
7.
ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs.
Proc Natl Acad Sci U S A;
105(2): 674-9, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18178618
8.
MiR-132 controls pancreatic beta cell proliferation and survival through Pten/Akt/Foxo3 signaling.
Mol Metab;
31: 150-162, 2020 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31918917
9.
Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in {beta}-cells.
J Cell Biol;
167(6): 1063-74, 2004 Dec 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15596545
10.
beta-Cells at the crossroads: choosing between insulin granule production and proliferation.
Diabetes Obes Metab;
11 Suppl 4: 54-64, 2009 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19817789
11.
Genes of type 2 diabetes in beta cells.
Endocrinol Metab Clin North Am;
35(2): 357-69, x, 2006 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16632098
12.
The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512.
Mol Metab;
5(8): 656-668, 2016 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27656403
13.
Selective mutagenesis of lysyl residues leads to a stable and active form of delta 9 stearoyl-CoA desaturase.
Biochim Biophys Acta;
1583(1): 45-52, 2002 Jun 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12069848
14.
Regulation of insulin granule turnover in pancreatic beta-cells by cleaved ICA512.
J Biol Chem;
283(48): 33719-29, 2008 Nov 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18824546
15.
A microsomal endopeptidase from liver that preferentially degrades stearoyl-CoA desaturase.
Biochemistry;
42(23): 6929-37, 2003 Jun 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12795587
16.
Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells.
J Biol Chem;
278(28): 26166-73, 2003 Jul 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12682071