1.
J Med Chem
; 18(10): 1000-3, 1975 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-808605
RESUMO
Norapomorphine and ten of its N-substituted derivatives were prepared by modifications of procedures described earlier. In a dog emesis test the N-ethyl and N-n-propyl compounds had minimum effective doses of 0.00025 and 0.0005 mg/kg, respectively, when administered iv, sc, or im. In a modified Irwin mouse profile screen the minimum effective iv dose was 0.013 mg/kg for the N-ethyl and 0.0024 mg/kg for the N-n-propyl compound; percutaneous absorption was also observed in mice. All compounds examined caused the stereotyped apomorphine behavior syndrome but hypotensive effects were not serious.
Assuntos
Apomorfina/análogos & derivados , Apomorfina/síntese química , Eméticos/síntese química , Animais , Apomorfina/farmacologia , Pressão Sanguínea/efeitos dos fármacos , Gatos , Depressão Química , Cães , Eméticos/farmacologia , Feminino , Haplorrinos , Humanos , Masculino , Camundongos , Comportamento Estereotipado/efeitos dos fármacos , Estimulação Química
2.
J Med Chem
; 10(2): 273-4, 1967 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6034080