Phonological neighbourhood effects in Italian speech production: Evidence from healthy and neurologically impaired populations.

In two speech production studies conducted in Italian, we investigated the impact of phonological neighbourhood properties such as the neighbourhood density and the mean frequency of the neighbours on speech processing. Two populations of healthy (Study 1) and neurologically impaired (Study 2) individuals were tested. We employed multi-regression methods to analyse naming latencies in Study 1 and accuracy rates in Study 2 while controlling for various psycholinguistic predictors. In Study 1, pictures with words from high-density neighbourhoods were named faster than those from low-density neighbourhoods. Additionally, words with high-frequency neighbours were named faster in Study 1 and yielded higher accuracy rates in Study 2. The results suggest facilitatory effects of both the phonological neighbourhood density and frequency neighbourhood variables. Furthermore, we observed interactions between these two phonological neighbourhood variables and name agreement and repetition. Specifically, the facilitation effect was more pronounced for pictures with lower name agreement and during the initial presentation of the pictures. These findings are discussed in the context of previous literature and within the framework of interactive models of speech production.

Cumulative semantic cost without successful naming.

Accessing semantic information has negative consequences for successive recovering attempts of similar information. For instance, in the course of picture-naming tasks, the time required to name an object is determined by the total number of items from the same category that have already been named; naming latencies increase proportionally to the total number of semantically related words named previously. This phenomenon is called cumulative semantic cost (or interference). Two picture-naming experiments with children (4-11 years old, 229 participants) investigate whether having successfully named the previous within-category items is a necessary condition for the cumulative semantic cost to appear. We anticipated that younger children would have a larger rate of nonresponses compared with older children, reflecting the fact that younger children have not yet consolidated many lexical representations. Our results confirmed this prediction. Critically, we also observed that cumulative semantic cost was independent of having successfully retrieved previous within-category lexical items. Furthermore, picture trials for which the previous within-category item elicited a nonresponse showed the same amount of cost as those picture trials for which the previous within-category item elicited a correct naming event. Our findings indicate that it is the attempt to retrieve a lexical unit, and not the successful retrieval of a specific lexical unit, that causes semantic cost in picture naming. This cost can be explained by a mechanism of weakening the semantic-to-lexical mappings of semantic coordinate words. The findings are also discussed in the context of retrieval-induced forgetting effects in memory recall research.

Outgroup faces hamper word recognition.

The present study explores socio-cultural priming in native-language processing. Caucasian Italian native speakers completed a written lexical decision task. Written stimuli were preceded by either a prime "white" face (ingroup condition) or a prime "black" face (outgroup condition). Face priming effects were observed in three experiments using different stimuli. Participants were slower in categorizing words, but not non-words, when preceded by an outgroup face than by an ingroup face. Several psycholinguistic variables were manipulated to localize the levels of processing that are affected by socio-cultural prime. The lack of effect with non-word items excludes the possibility that the face priming effect arises at perceptual or attentive levels of processing. In addition, we observed that while the face priming effect does not interact with lexical dimensions, it does interact with a semantic dimension such as imageability. The results indicate that social categories extracted from faces may modulate lexico-semantic processing. Interestingly, such a modulation would occur in the context of a quick and automatic process like visual word recognition in a person's native language.

VRT (verbal reasoning test): a new test for assessment of verbal reasoning. Test realization and Italian normative data from a multicentric study.

Verbal reasoning is a complex, multicomponent function, which involves activation of functional processes and neural circuits distributed in both brain hemispheres. Thus, this ability is often impaired after brain injury. The aim of the present study is to describe the construction of a new verbal reasoning test (VRT) for patients with brain injury and to provide normative values in a sample of healthy Italian participants. Three hundred and eighty healthy Italian subjects (193 women and 187 men) of different ages (range 16-75 years) and educational level (primary school to postgraduate degree) underwent the VRT. VRT is composed of seven subtests, investigating seven different domains. Multiple linear regression analysis revealed a significant effect of age and education on the participants' performance in terms of both VRT total score and all seven subtest scores. No gender effect was found. A correction grid for raw scores was built from the linear equation derived from the scores. Inferential cut-off scores were estimated using a non-parametric technique, and equivalent scores were computed. We also provided a grid for the correction of results by z scores.

Effectiveness of vagal nerve stimulation in medication-resistant epilepsy. Comparison between patients with and without medication changes.

BACKGROUND: Vagal nerve stimulation (VNS) response is not immediate. A progressive decline in seizure frequency is usually found during a period of 12-18 months after implantation. During this time, the patient's medication is usually modified, which can create doubts about whether their clinical improvement is due to medication changes or to VNS itself. Our goal is to compare two groups of patients treated with VNS, with and without changes in their medication. METHODS: We prospectively analyze 85 patients who were treated with VNS in our hospital between 2005 and 2014. In 43 patients, changes in the antiepileptic drugs (EAD) were not allowed during the postoperative follow-up and they were compared with 42 patients who were left at the option of neurologist make changes in medication. We analyzed the clinical situation at 18 months and compared the two groups. RESULTS: Overall, 54.1% of patients had a reduction in seizures of 50% or higher (responders). In the group with no changes in medication, responders reached 63%, while in the group in which changes in medication were allowed, 45.2% were responders. Between responders and non-responders, there were no statistical differences in type of epilepsy, frequency, previous surgery, or intensity of stimulation. CONCLUSIONS: We did not find a statistical difference in seizure frequency reduction between patients with or without changes in medication during their follow-up, so changes in medication did not improve the outcome. Furthermore, the absence of changes in AED can help to optimize the parameters of the stimulator in order to improve its effectiveness.

Acquisition of nouns and verbs in Italian pre-school children.

Noun and verb acquisition was investigated in three- and five-year-old Italian children by means of picture naming of objects and actions, selected from Druks and Masterson (2000). The aim was to examine the previously reported advantage of nouns compared to verbs. Older children were faster than younger children, and naming latencies were faster for object pictures than for action pictures. For errors, the advantage of objects over actions was greater for younger children. A qualitative analysis of errors was carried out according to a classification derived by Masterson, Druks, and Gallienne (2008). Overall, 25% of the errors reflected a complete lack of knowledge of the names or of the meanings of the pictures. Most errors, however, were likely to be due to a not yet fully developed knowledge of the meaning of words labelling the pictures, or to an incomplete conceptual representation, and this pattern was more marked for action concepts.

Antecedent Frequency Effects on Anaphoric Pronoun Resolution: Evidence from Spanish.

High-frequency words are usually understood and produced faster than low-frequency words. Although the effect of word frequency is a reliable phenomenon in many domains of language processing, it remains unclear whether and how frequency affects pronominal anaphoric resolution. We evaluated this issue by means of two self-paced reading experiments. Native speakers of Spanish read sentences containing the anaphoric noun or pronoun at the subject syntactic position (Experiment 1) or at the object syntactic position (Experiment 2) while the antecedent of the anaphor was either a high-frequency or a low-frequency word. Results showed that nominal anaphors were read faster when referring to high-frequency than to low-frequency antecedents, and faster when referring to subjects than to objects. Critically, pronoun reading times were unaffected by the frequency and by the syntactic position of the antecedent. These results are congruent with theories assuming that syntactic information of the words is not frequency sensitive.

The Italian version of the Brain Injury Rehabilitation Trust (BIRT) personality questionnaires: five new measures of personality change after acquired brain injury.

The aim of this study was to describe the translation and adaptation of the BIRT personality questionnaires for the Italian population. This included the replication of validity testing and the collection of normative data. Following translation and adaptation according to cross-cultural guidelines, the questionnaires were administered as a pre-test to a sample of 20 healthy subjects and then to 10 patients. The questionnaires were then administered to 120 healthy subjects equally distributed by sex, education, and age, to collect normative data from an Italian population. The questionnaires were easily administered to both healthy subjects and patients. Statistical analysis on normative data was conducted to find the mean value for each questionnaire. This study lays the foundations for using a new instrument to assess behavioral changes after acquired brain injury on the Italian population.

First learned words are not forgotten: Age-of-acquisition effects in the tip-of-the-tongue experience.

A large body of evidence indicates that the age at which a word is acquired predicts the time required to retrieve that word during speech production. Here we explored whether age of acquisition also predicts the experience of being unable to produce a known word at a particular moment. Italian speakers named a sequence of pictures in Experiment 1 or retrieved a word as a response to a definition in Experiment 2. In both experiments, the participants were instructed to indicate when they were in a tip-of-the-tongue (TOT) state. Generalized mixed-effects models performed on the TOT and correct responses revealed that word frequency and age of acquisition predicted the TOT states. Specifically, low-frequency words elicited more TOTs than did high-frequency words, replicating previous findings. In addition, late-acquired words elicited more TOTs than did early-acquired words. Further analyses revealed that the age of acquisition was a better predictor of TOTs than was word frequency. The effects of age of acquisition were similar with subjective and objective measures of age of acquisition, and persisted when several psycholinguistic variables were taken into consideration as predictors in the generalized mixed-effects models. We explained these results in terms of weaker semantic-to-phonological connections in the speech production system for late-acquired words.

With or without semantic mediation: retrieval of lexical representations in sign production.

How are lexical representations retrieved during sign production? Similar to spoken languages, lexical representation in sign language must be accessed through semantics when naming pictures. However, it remains an open issue whether lexical representations in sign language can be accessed via routes that bypass semantics when retrieval is elicited by written words. Here we address this issue by exploring under which circumstances sign retrieval is sensitive to semantic context. To this end we replicate in sign language production the cumulative semantic cost: The observation that naming latencies increase monotonically with each additional within-category item that is named in a sequence of pictures. In the experiment reported here, deaf participants signed sequences of pictures or signed sequences of Italian written words using Italian Sign Language. The results showed a cumulative semantic cost in picture naming but, strikingly, not in word naming. This suggests that only picture naming required access to semantics, whereas deaf signers accessed the sign language lexicon directly (i.e., bypassing semantics) when naming written words. The implications of these findings for the architecture of the sign production system are discussed in the context of current models of lexical access in spoken language production.

Does Foreign-Accented Speech Affect Credibility? Evidence from the Illusory-Truth Paradigm.

In a pioneering study, Lev-Ari and Keysar (2010) observed that unknown statements are judged less credible when uttered with foreign accent compared to native accent. This finding was interpreted in terms of processing fluency; when intelligibility is reduced, the credibility of the message decreases. Here, we use the illusory truth paradigm to explore how accent affects credibility. In a between-participant design, participants were exposed to unknown statements uttered by native-accented or foreign-accented speakers. After a distractor task, the same statements were presented with new statements, and participants assessed their truthfulness. Truthfulness ratings were higher for repeated statements than for new statements, replicating the illusory truth effect. Contrary to the processing fluency hypothesis, the effect was similar in both the foreign-accented and native-accented speech groups. A new group of participants rated the speakers' voices on various social traits. A negative bias against foreign speakers was observed. However, this negative-bias did not affect truth ratings.The impact of foreign-accented speech on message credibility is discussed in the context of two factors, processing fluency and out-group stereotype activation.

Impact of sex on clinical and laboratory parameters in patients with heart failure: insights from the Colombian Heart Failure Registry (RECOLFACA).

INTRODUCTION: Heart failure (HF) is one of the leading causes of morbidity and mortality worldwide. This study aimed to assess the impact of sex on sociodemographic, clinical, and laboratory parameters in patients with HF who were included in the Colombian Heart Failure Registry (RECOLFACA). METHODS: This was a cross-sectional analytical research. All 2528 patients included in RECOLFACA were analysed. The Mann-Whitney U test was used to compare median values as well as first and third quartiles (Q1-Q3). The age-related trend of NT-proBNP levels for both men and women groups was statistically evaluated. RESULTS: The study included 2528 patients with HF (1072 women and 1456 men). The echocardiographic evidence showed that men presented reduced left ventricular ejection fraction (LVEF) (79.63 vs. 69.75%, respectively; p < 0.001) more often than women, which had a significantly higher proportion of preserved LVEF (20.46 vs.11.24%, respectively; p < 0.001). Women displayed a higher value of systolic blood pressure (p < 0.001) and heart rate (p = 0.014) compared to men. Haemoglobin, creatinine, and sodium levels were significantly higher in men. Men had a considerably lower glomerular filtration rate value, with the median reaching a G3a value for chronic renal failure. According to age, the levels of NT-proBNP in each sex increased equivalently with age. CONCLUSION: Sex differences presented in this study are comparable to those discovered in other nations. However, certain variations show that these sex differences may differ by geographical area, which should encourage further investigations to describe them.

Eligibility of sodium-glucose cotransporter-2 inhibitors in heart failure with preserved ejection fraction: Insights from the Colombian heart failure registry (RECOLFACA).

Background: The value of Sodium-glucose cotransporter-2 inhibitors (SGLT-2 inhibitor) therapy in individuals with heart failure with preserved EF (HFpEF) was unknown until the EMPEROR-Preserved trial. We aimed to assess the proportion of patients with HFpEF that are eligible for empagliflozin therapy within the Colombian Heart Failure Registry (RECOLFACA). Methods: RECOLFACA enrolled adult patients with a HF diagnosis during 2017-2019 from 60 medical centers in Colombia. Criteria of the EMPEROR-Preserved Trial were used to recruit participants. The main outcome was individual eligibility with N-terminal pro-B-type natriuretic peptide (NT-proBNP) criteria, while the secondary outcome was eligibility without NT-proBNP data. Results: RECOLFACA had 799 patients with HFpEF (mean age70.7 ± 13.5; 50.7 % males). According to the major selection criteria of the EMPEROR Preserved Trial, 73.7 % patients would be eligible for empagliflozin therapy initiation when considering the NT-proBNP threshold. The NT-proBNP threshold represented the main determinant of ineligibility in patients with this biomarker measure (13.6 %; n = 16). In patients without NT-proBNP data, the main reasons for exclusion were the diagnosis of symptomatic hypotension or a systolic blood pressure below 100 mmHg (7.5 %), having an eGFR < 20 ml/min/1.73 m2 (4.3 %), and haemoglobin < 9 g/dl (3.1 %). Excluding NT-proBNP criteria increased empagliflozin eligibility to 80.6 %. Conclusion: Most patients with HFpEF from RECOLFACA are potential candidates for empagliflozin therapy initiation according to the EMPEROR-Preserved trial criteria. These findings favor the utilization of SGLT-2 inhibitor medications in daily medical practice, which may further decrease morbidity and mortality in HF patients, regardless of their EF classification.

Deep brain stimulation of the centromedian thalamic nucleus for the treatment of generalized and frontal epilepsies.

PURPOSE: Deep brain stimulation (DBS) of the thalamus is an emerging surgical option for people with medically refractory epilepsy that is not suitable for resective surgery, or in whom surgery has failed. Our main aim was to evaluate the efficacy of bilateral centromedian thalamic nucleus (CMN) DBS for seizure control in generalized epilepsy and frontal lobe epilepsy with a two-center, single-blind, controlled trial. METHODS: Participants were adults with refractory generalized or frontal lobe epilepsy. Seizure diaries were kept by patients/carers prospectively from enrollment. The baseline preimplantation period was followed by a control period consisting of a blind stimulation-OFF phase of at least 3 months, a 3-month blind stimulation-ON phase, and a 6-month unblinded stimulation-ON phase. The control period was followed by an unblinded long-term extension phase with stimulation-ON in those patients in whom stimulation was thought to be effective. KEY FINDINGS: Eleven patients were recruited at King's College Hospital (London, United Kingdom United Kingdom) and at University Hospital La Princesa (Madrid, Spain). Among the five patients with frontal lobe epilepsy, only one patient had >50% improvement in seizure frequency during the blind period. In the long-term extension phase, two patients with frontal lobe epilepsy had >50% improvement in seizure frequency. All six patients with generalized epilepsy had >50% improvement in seizure frequency during the blind period. In the long-term extension phase, five of the six patients showed >50% improvement in the frequency of major seizures (one became seizure free, one had >99% improvement, and three had 60-95% reduction in seizure frequency). Among patients with generalized epilepsy, the DBS implantation itself appears to be effective, as two patients remained seizure free during 12 and 50 months with DBS OFF, and the remaining four had 50-91% improvement in the initial 3 months with DBS OFF. SIGNIFICANCE: DBS implantation and stimulation of the CMN appears to be a safe and efficacious treatment, particularly in patients with refractory generalized epilepsy. CMN stimulation was not as effective in frontal lobe epilepsy, which requires further studies. DBS of the CMN should be considered as a treatment option, particularly in patients with refractory generalized epilepsy syndromes.

Verbal deception in picture naming.

Telling a lie requires several cognitive processes. We investigated three cognitive processes involved in verbal deception: the decision to deceive, the suppression of the true statement, and the construction of the false statement. In a standard picture-naming task, participants were instructed to commit true and false naming statements. Critically, participants could freely decide to name the picture (i.e., true naming events) or to commit a verbal deception and use a different name (i.e., false naming events). Different types of analysis were performed with the aim of exploring the influence of semantic, lexical, and phonological information of the target picture in the decision, suppression, and construction processes. The first type of analysis revealed that participants decided to lie more often when the target picture was less typical or less familiar. The second and third types of analysis focused on the false naming events. False naming latencies turned out to be faster when the name of the target picture was a highly frequent or an earlier-acquired name, suggesting an influence of lexical variables in the suppression of the true statement. The third analysis type explored the phonological relationship between the word that participants uttered in the false statements and the target picture name. No phonological influences emerged in this last analysis. These findings demonstrate that verbal deception is tied to semantic and lexical variables corresponding to true statements.

Linguistic identity as a modulator of gaze cueing of attention.

Eye-gaze stimuli can elicit orienting of attention in an observer, a phenomenon known as gaze cueing of attention. Here, we explored whether gaze cueing can be shaped by the linguistic identity of the cueing face. In two experiments, participants were first familiarized with different faces together with auditory sentences. Half of the sentences were associated with the native language of the participants (Italian) and the other half with an unknown language (Albanian and Basque, in Experiments 1 and 2, respectively). In a second phase, participants performed a gaze-cueing task. In a third recognition phase, the auditory sentences were presented again, and participants were required to decide which face uttered each sentence. Results indicated that participants were more likely to confuse faces from the same language category than from the other language category. Results of the gaze-cueing task revealed a greater gaze-cueing effect for faces associated with the native vs. unknown language. Critically, this difference emerged only in Experiment 1, which may reflect differences in social status between the two language groups. Our findings revealed the impact of language as a social cue on the gaze-cueing effect, suggesting that social attention is sensitive to the language of our interlocutors.

[Primary prophylaxis of early seizures after surgery of cerebral supratentorial tumors: Group for the Study of Functional-Sterotactic Neurosurgery of The Spain Society of Neurosurgery recommendations]. / Control de las crisis epilépticas durante el postoperatorio inmediato de los tumores cerebrales supratentoriales: recomendaciones del Grupo de Neurocirugía Funcional y Estereotáctica de la Sociedad Española de Neurocirugía.

Our review of the literature is basically focused on the primary prophylaxis of early seizures after surgery of cerebral supratentorial tumors, with the aim of suggesting several recommendations in medical antiepileptic treatment to avoid this kind of seizures which occur immediately after surgery. In conclusion, it is recommended to provide criteria for prophylaxis of early seizures after surgery of cerebral supratentorial tumors. It́s recommended a one week treatment with antiepileptic drugs in patients who didnt have seizures jet, starting immediately after the surgical treatment. If seizures appear during progress of the disease, a large period treatment will be needed. Preferred antiepileptic treatment is intravenous and with a low interactions profile. Levetiracetam, followed by valproic acid seem to be most appropriated drugs due to their properties and protective effects, particularly for our patients requirements. These recommendations are considered a general proposal to effective clinical management of early seizures after surgery, not taking into account the single circumstances of our patients. Always, clinical features of the patients could modify even significantly these guides in the benefit of each patient.

Exploring the ventral white matter language network in bimodal and unimodal bilinguals.

We used diffusion magnetic resonance imaging tractography to investigate the effect of language modality on the anatomy of the ventral white matter language network by comparing unimodal (Italian/English) and bimodal bilinguals (Italian/Italian Sign Language). We extracted the diffusion tractography measures of the Inferior Longitudinal fasciculus (ILF), Uncinate fasciculus (UF) and Inferior Fronto-Occipital fasciculus (IFOF) and we correlated them with the degree of bilingualism and the individual performance in fluency tasks. For both groups of bilinguals, the microstructural properties of the right ILF were correlated with individual level of proficiency in L2, confirming the involvement of this tract in bilingualism. In addition, we found that the degree of left lateralization of the ILF predicted the performance in semantic fluency in L1. The microstructural properties of the right UF correlated with performance in phonological fluency in L1, only for bimodal bilinguals. Overall, the pattern shows both similarities and differences between the two groups of bilinguals.