Detalhe da pesquisa
1.
An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma.
Mol Cell;
82(16): 3030-3044.e8, 2022 08 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35764091
2.
P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage.
Cell;
158(6): 1324-1334, 2014 Sep 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25215490
3.
Cancer vulnerabilities unveiled by genomic loss.
Cell;
150(4): 842-54, 2012 Aug 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22901813
4.
ß-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis.
Cell;
151(7): 1457-73, 2012 Dec 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23245941
5.
A Medicinal Chemistry-Driven Approach Identified the Sterol Isomerase EBP as the Molecular Target of TASIN Colorectal Cancer Toxins.
J Am Chem Soc;
142(13): 6128-6138, 2020 04 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32163279
6.
The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α.
Nat Chem Biol;
12(7): 511-5, 2016 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27182663
7.
Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase.
Nat Chem Biol;
12(4): 218-25, 2016 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26829472
8.
Synthesis and Biological Evaluation of Kibdelone C and Its Simplified Derivatives.
J Am Chem Soc;
138(33): 10561-70, 2016 08 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27459345
9.
Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3.
Cell Chem Biol;
31(1): 139-149.e14, 2024 01 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37967558
10.
Thiophenyl Derivatives of Nicotinamide Are Metabolized by the NAD Salvage Pathway into Unnatural NAD Derivatives That Inhibit IMPDH and Are Toxic to Peripheral Nerve Cancers.
ACS Chem Biol;
2024 Jun 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38829020
11.
Discovery and Optimization of N-Arylated Tetracyclic Dicarboximides That Target Primary Glioma Stem-like Cells.
J Med Chem;
2024 May 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38804887
12.
Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production.
Cell Chem Biol;
30(2): 214-229.e18, 2023 02 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36758549
13.
Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules.
bioRxiv;
2023 Feb 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36865268
14.
Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex.
Nat Commun;
14(1): 3762, 2023 06 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37353483
15.
Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules.
Cell Chem Biol;
30(11): 1453-1467.e8, 2023 11 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37607550
16.
MIF is a 3' flap nuclease that facilitates DNA replication and promotes tumor growth.
Nat Commun;
12(1): 2954, 2021 05 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34012010
17.
Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models.
Sci Adv;
7(47): eabj5405, 2021 Nov 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34788094
18.
Target Discovery of Selective Non-Small-Cell Lung Cancer Toxins Reveals Inhibitors of Mitochondrial Complex I.
ACS Chem Biol;
15(1): 158-170, 2020 01 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31874028
19.
Tumor-Activated Benzothiazole Inhibitors of Stearoyl-CoA Desaturase.
J Med Chem;
63(17): 9773-9786, 2020 09 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32787093
20.
Exome Sequencing of Drug-Resistant Clones for Target Identification.
Methods Mol Biol;
1888: 175-187, 2019.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30519947