Correlations Between Personality and Brain Structure: A Crucial Role of Gender.

Previous studies have shown that males and females differ in personality and gender differences have also been reported in brain structure. However, effects of gender on this "personality-brain" relationship are yet unknown. We therefore investigated if the neural correlates of personality differ between males and females. Whole brain voxel-based morphometry was used to investigate the influence of gender on associations between NEO FFI personality traits and gray matter volume (GMV) in a matched sample of 182 males and 182 females. In order to assess associations independent of and dependent on gender, personality-GMV relationships were tested across the entire sample and separately for males and females. There were no significant correlations between any personality scale and GMV in the analyses across the entire sample. In contrast, significant associations with GMV were detected for neuroticism, extraversion, and conscientiousness only in males. Interestingly, GMV in left precuneus/parieto-occipital sulcus correlated with all 3 traits. Thus, our results indicate that brain structure-personality relationships are highly dependent on gender, which might be attributable to hormonal interplays or differences in brain organization between males and females. Our results thus provide possible neural substrates of personality-behavior relationships and underline the important role of gender in these associations.

Neuro-computational mechanisms and individual biases in action-outcome learning under moral conflict.

Learning to predict action outcomes in morally conflicting situations is essential for social decision-making but poorly understood. Here we tested which forms of Reinforcement Learning Theory capture how participants learn to choose between self-money and other-shocks, and how they adapt to changes in contingencies. We find choices were better described by a reinforcement learning model based on the current value of separately expected outcomes than by one based on the combined historical values of past outcomes. Participants track expected values of self-money and other-shocks separately, with the substantial individual difference in preference reflected in a valuation parameter balancing their relative weight. This valuation parameter also predicted choices in an independent costly helping task. The expectations of self-money and other-shocks were biased toward the favored outcome but fMRI revealed this bias to be reflected in the ventromedial prefrontal cortex while the pain-observation network represented pain prediction errors independently of individual preferences.

Age differences in predicting working memory performance from network-based functional connectivity.

Deterioration in working memory capacity (WMC) has been associated with normal aging, but it remains unknown how age affects the relationship between WMC and connectivity within functional brain networks. We therefore examined the predictability of WMC from fMRI-based resting-state functional connectivity (RSFC) within eight meta-analytically defined functional brain networks and the connectome in young and old adults using relevance vector machine in a robust cross-validation scheme. Particular brain networks have been associated with mental functions linked to WMC to a varying degree and are associated with age-related differences in performance. Comparing prediction performance between the young and old sample revealed age-specific effects: In young adults, we found a general unpredictability of WMC from RSFC in networks subserving WM, cognitive action control, vigilant attention, theory-of-mind cognition, and semantic memory, whereas in older adults each network significantly predicted WMC. Moreover, both WM-related and WM-unrelated networks were differently predictive in older adults with low versus high WMC. These results indicate that the within-network functional coupling during task-free states is specifically related to individual task performance in advanced age, suggesting neural-level reorganization. In particular, our findings support the notion of a decreased segregation of functional brain networks, deterioration of network integrity within different networks and/or compensation by reorganization as factors driving associations between individual WMC and within-network RSFC in older adults. Thus, using multivariate pattern regression provided novel insights into age-related brain reorganization by linking cognitive capacity to brain network integrity.

Predicting personality from network-based resting-state functional connectivity.

Personality is associated with variation in all kinds of mental faculties, including affective, social, executive, and memory functioning. The intrinsic dynamics of neural networks underlying these mental functions are reflected in their functional connectivity at rest (RSFC). We, therefore, aimed to probe whether connectivity in functional networks allows predicting individual scores of the five-factor personality model and potential gender differences thereof. We assessed nine meta-analytically derived functional networks, representing social, affective, executive, and mnemonic systems. RSFC of all networks was computed in a sample of 210 males and 210 well-matched females and in a replication sample of 155 males and 155 females. Personality scores were predicted using relevance vector machine in both samples. Cross-validation prediction accuracy was defined as the correlation between true and predicted scores. RSFC within networks representing social, affective, mnemonic, and executive systems significantly predicted self-reported levels of Extraversion, Neuroticism, Agreeableness, and Openness. RSFC patterns of most networks, however, predicted personality traits only either in males or in females. Personality traits can be predicted by patterns of RSFC in specific functional brain networks, providing new insights into the neurobiology of personality. However, as most associations were gender-specific, RSFC-personality relations should not be considered independently of gender.