Detalhe da pesquisa
1.
Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: A multi-target compound with potential therapeutic applications.
Blood Cells Mol Dis;
106: 102827, 2024 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38301450
2.
Rutin improves glutamate uptake and inhibits glutamate excitotoxicity in rat brain slices.
Mol Biol Rep;
48(2): 1475-1483, 2021 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33492574
3.
Semi-synthetic sapogenin exerts neuroprotective effects by skewing the brain ischemia reperfusion transcriptome towards inflammatory resolution.
Brain Behav Immun;
64: 103-115, 2017 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28390980
4.
In Vitro Neuroprotective and Anti-Inflammatory Activities of Natural and Semi-Synthetic Spirosteroid Analogues.
Molecules;
21(8)2016 Jul 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27483221
5.
Carcinogenic effect of human tumor-derived cell-free filtrates in nude mice.
Front Mol Biosci;
11: 1361377, 2024.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38698774
6.
JM-20 potently prevents the onset of caffeine-induced anxiogenic phenotypes in zebrafish (Danio rerio).
Comp Biochem Physiol C Toxicol Pharmacol;
277: 109843, 2024 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38237841
7.
JM-20 affects GABA neurotransmission in Caenorhabditis elegans.
Neurotoxicology;
93: 37-44, 2022 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36029931
8.
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species.
Neurotox Res;
40(6): 2135-2147, 2022 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35997936
9.
The anti-cancer agent guttiferone-A permeabilizes mitochondrial membrane: ensuing energetic and oxidative stress implications.
Toxicol Appl Pharmacol;
253(3): 282-9, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21549140
10.
JM-20 Treatment After Mild Traumatic Brain Injury Reduces Glial Cell Pro-inflammatory Signaling and Behavioral and Cognitive Deficits by Increasing Neurotrophin Expression.
Mol Neurobiol;
58(9): 4615-4627, 2021 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34148214
11.
Novel arylidene malonate derivative, KM-34, showed neuroprotective effects on in vitro and in vivo models of ischemia/reperfusion.
Eur J Pharmacol;
899: 174025, 2021 May 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33722590
12.
JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson's disease: Mitochondrial protection and antioxidant properties.
Neurotoxicology;
82: 89-98, 2021 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33232743
13.
JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats.
Neurotoxicology;
87: 70-85, 2021 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34481871
14.
Molecular docking and in vitro evaluation of a new hybrid molecule (JM-20) on cholinesterase activity from different sources.
Biochimie;
168: 297-306, 2020 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31770565
15.
JM-20 Treatment After MCAO Reduced Astrocyte Reactivity and Neuronal Death on Peri-infarct Regions of the Rat Brain.
Mol Neurobiol;
56(1): 502-512, 2019 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29725905
16.
JM-20, a novel hybrid molecule, protects against rotenone-induced neurotoxicity in experimental model of Parkinson's disease.
Neurosci Lett;
690: 29-35, 2019 01 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30304707
17.
KM-34, a Novel Antioxidant Compound, Protects against 6-Hydroxydopamine-Induced Mitochondrial Damage and Neurotoxicity.
Neurotox Res;
36(2): 279-291, 2019 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29294239
18.
JM-20 protects memory acquisition and consolidation on scopolamine model of cognitive impairment.
Neurol Res;
41(5): 385-398, 2019 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30821663
19.
Multi-targeting effects of a new synthetic molecule (JM-20) in experimental models of cerebral ischemia.
Pharmacol Rep;
70(4): 699-704, 2018 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29933207
20.
Antioxidant and Neuroprotective Effects of KM-34, A Novel Synthetic Catechol, Against Oxidative Stress-Induced Neurotoxicity.
Drug Res (Stuttg);
68(5): 263-269, 2018 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29100263