Impact of Using Processed Urinary Bladder Submucosa and Hydrogel Fabricated from Tendon on Skin Healing Process in Rabbits.

This study was intended to evaluate the healing of skin injury by using decellularized urinary bladder submucosa scaffolds and tendon-derived hydrogel. Thirty-six adult local breeds of both sex rabbits, with an average weight of 2.0-2.5 kg, were divided randomly into three groups (12 animals for each group). All groups were subjected to an induced injury (2 cm) in diameter at the right side of the abdominal skin, the rabbits of the 1st group (A) were sutured without the application of any substance as a control group, the rabbits of the 2nd group (B) were sutured and treated with the application of decellularized urinary bladder submucosa scaffolds, and in the 3rd group (C), they were sutured and treated with the application of tendon-derived hydrogel. Postoperative care following had been done for all groups throughout the study period. Specimens from the injured skin were taken for the histopathological study on the postinjury day, 8th, 14th, 21st, and 24th. The study showed a clear effect of materials used in the treatment of wounds through a clear progression in the healing stages with a noticed superiority of the submucosa scaffold group.

Peak expiratory flow with or without a brief postinspiratory pause.

BACKGROUND: The duration of postinspiratory pause prior to forced expiration may significantly influence the peak expiratory flow (PEF) measured during maximal forceful expirations. In comparison with maneuvers without a postinspiratory pause, maneuvers with 4 to 6-s pause at total lung capacity (TLC) result in decreased PEF values. The extent to which brief pauses (< 2 s) similarly affect PEF values is unknown. METHODS: Thirty-six healthy volunteers (mean [+/-SD] age, 35 +/- 8 years; 18 men) performed a series of maximal forceful expirations with two different types of maneuvers. One maneuver (NP) included no inspiratory pause at TLC prior to forceful expiration, whereas the second (P) included a brief pause (< or = 2 s). The speed of inhalation to TLC was rapid and similar for both maneuvers. The highest PEF for each maneuver was used for analysis. RESULTS: The maximal PEF did not differ (p > 0.05) between the P and NP maneuvers (7.78 +/- 1.45 vs 7.83 +/- 1.45 L/s, respectively). Comparison of the intermaneuver differences showed a bias of 0.05 L/s and 95% confidence interval in the range of -0.9 to 1.0 L/s. CONCLUSIONS: Forceful expiratory maneuvers with or without postinspiratory pauses of < or = 2 s produce identical maximal PEF values and, therefore, can be used interchangeably for the spirometric measurement of PEF in healthy subjects.