Detalhe da pesquisa
1.
Plant-made dengue virus-like particles produced by co-expression of structural and non-structural proteins induce a humoral immune response in mice.
Plant Biotechnol J;
19(4): 745-756, 2021 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33099859
2.
The structure of human GCN2 reveals a parallel, back-to-back kinase dimer with a plastic DFG activation loop motif.
Biochem J;
477(1): 275-284, 2020 01 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31868900
3.
A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding.
Biochem J;
477(22): 4443-4452, 2020 11 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33119085
4.
Introduction of a C-terminal hexa-lysine tag increases thermal stability of the LacDiNac binding adhesin (LabA) exodomain from Helicobacter pylori.
Protein Expr Purif;
163: 105446, 2019 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31271862
5.
Development of Specific, Irreversible Inhibitors for a Receptor Tyrosine Kinase EphB3.
J Am Chem Soc;
138(33): 10554-60, 2016 08 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27478969
6.
Quantitative investigation of the affinity of human respiratory syncytial virus phosphoprotein C-terminus binding to nucleocapsid protein.
Virol J;
11: 191, 2014 Nov 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25407889
7.
Engineered Cas9 extracellular vesicles as a novel gene editing tool.
J Extracell Vesicles;
11(5): e12225, 2022 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35585651
8.
Structural and binding characterization of the LacdiNAc-specific adhesin (LabA; HopD) exodomain from Helicobacter pylori.
Curr Res Struct Biol;
3: 19-29, 2021.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34235483
9.
Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy.
J Med Chem;
64(6): 3165-3184, 2021 03 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33683117
10.
Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors.
Sci Transl Med;
12(541)2020 04 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32350132
11.
Endosomal escape enhancing compounds facilitate functional delivery of extracellular vesicle cargo.
Nanomedicine (Lond);
14(21): 2799-2814, 2019 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31724479
12.
KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.
Nat Commun;
10(1): 2607, 2019 06 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31197133
13.
Rapid isolation and enrichment of extracellular vesicle preparations using anion exchange chromatography.
Sci Rep;
8(1): 5730, 2018 04 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29636530
14.
Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J Med Chem;
61(19): 8797-8810, 2018 10 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30204441
15.
A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases.
ACS Chem Biol;
12(6): 1499-1503, 2017 06 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28459525
16.
Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.
Nat Commun;
8: 16111, 2017 07 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28706291
17.
Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis.
Cancer Res;
76(3): 724-35, 2016 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26637668
18.
Structural basis of Lewis(b) antigen binding by the Helicobacter pylori adhesin BabA.
Sci Adv;
1(7): e1500315, 2015 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26601230
19.
Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation.
J Med Chem;
58(5): 2265-74, 2015 Mar 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25695162
20.
Completing the structural family portrait of the human EphB tyrosine kinase domains.
Protein Sci;
23(5): 627-38, 2014 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24677421