Multidimensional Spectral Phasors of LAURDAN's Excitation-Emission Matrices: The Ultimate Sensor for Lipid Phases?

The impact of lipid diversity on the lateral organization of biological membranes remains a topic of debate. While the existence of domains in lamellar membranes is well-established, the nonlamellar phases occurring in biological systems are less explored due to technical constraints. Here, we present the measurement of the excitation-emission matrices (EEM) of LAURDAN in several lipid structures. LAURDAN is a fluorescence probe widely used for characterizing lipid assemblies. The EEMs were analyzed by multidimensional spectral phasors (MdSP), an approach that seizes information from both the excitation and emission spectra. We developed a computer algorithm to construct EEM data based on a model for LAURDAN's photophysics. The MdSP calculated from the simulated EEMs reveals that all feasible possibilities lie inside a universal triangle in the phasor's plot. We use this triangle to propose a ternary representation for the phasors, allowing a better assessment of LAURDAN's surroundings in terms of hydration, water mobility, and local electronic environment. Building upon this foundation, we constructed a theoretical "phase map" that can assess both lamellar and nonlamellar membranes. We thoroughly validated this theory using well-known lipid mixtures under different phase-state conditions and enzymatically generated systems. Our results confirm that the use of MdSP is a powerful tool for obtaining quantitative information on both lamellar and nonlamellar structures. This study not only advances our understanding of the impact of lipid diversity on membrane organization but also provides a robust and general framework for the assessment of fluorescence properties that can be further extended to other probes.

Ocular Surface Characteristics in Pugs with Pigmentary Keratitis in the Canary Islands, Spain.

This study investigated the prevalence of pigmentary keratitis (PK) in Pug-breed dogs and described the ocular surface characteristics associated with this disease. A total of 219 eyes from 110 dogs were examined, with 94.5% of them affected by PK. Age, previous ocular diseases, corneal vascularization, and corneal sensitivity were significantly associated with the presence of PF and the severity of corneal pigmentation. The study also found that low tear production and blinks incomplete with tear signs, as well as reduced corneal sensitivity, were linked to more severe forms of corneal pigmentation. The Tear Ferning Test (TFT) was identified as a valuable tool for evaluating tear quality in dogs, with worse test results indicating a higher risk of severe PK. A lower mean Tear Break-Up Time (TBUT) test was observed in dogs with PK. Additionally, the study observed a statistically significant difference in corneal thickness between the nasal and temporal zones, with the nasal zone being thicker. It was also suggested that sex and fertility status may influence the incidence of PK and the severity of corneal pigmentation. Overall, these findings provide insight into the underlying causes of PK in Pugs and can inform future treatment strategies for this breed.

Ethnoracial Disparities in Perinatal Outcomes Among Women Veterans.

Objective: Non-Hispanic Black women have increased rates of preterm birth and low infant birth weight. However, we do not know if these disparities replicate in women veterans, a population that may be at further risk for poor perinatal outcomes. This study sought to examine ethnoracial differences in preterm birth and low infant birth weight in veterans. Methods: A national sample of randomly chosen women veterans (i.e., oversampled for residency in high crime neighborhoods) reported information about all pregnancies they have had in their life, demographic characteristics, and history of childhood trauma exposures. The analytic sample was limited to individuals who identified as Hispanic/Latinx, Black, or White (n = 972). Mixed-effects regression models were used to examine ethnoracial differences in gestational age at delivery and infant birth weight, controlling for age at pregnancy, childhood trauma exposure, pregnancy during military service, income, and education. Results: Both Black and Hispanic/Latinx veterans were significantly more likely to have an infant born at lower gestational age (B = -1.04 and B = -1.11, respectively) and lower infant birth weight (B = -195.83 and B = -144.27, respectively) as compared with White veterans in covariate-adjusted models. Black (odds ratio = 3.24, confidence interval = 1.16, 9.09) veterans were more likely to meet the clinical definition of preterm birth as compared with White veterans. Conclusions: Results align with what is seen in the general population regarding ethnoracial disparities in gestational age at delivery and infant birth weight. Findings highlight the critical need for more research on mechanisms and prevention efforts for ethnoracial disparities in perinatal outcomes.

Cellular targets and lysine selectivity of the HERC5 ISG15 ligase.

ISG15 is a type I interferon-induced ubiquitin-like modifier that functions in innate immune responses. The major human ISG15 ligase is hHERC5, a ribosome-associated HECT E3 that broadly ISGylates proteins cotranslationally. Here, we characterized the hHERC5-dependent ISGylome and identified over 2,000 modified lysines in over 1,100 proteins in IFN-ß-stimulated cells. In parallel, we compared the substrate selectivity hHERC5 to the major mouse ISG15 ligase, mHERC6, and analysis of sequences surrounding ISGylation sites revealed that hHERC5 and mHERC6 have distinct preferences for amino acid sequence context. Several features of the datasets were consistent with ISGylation of ribosome-tethered nascent chains, and mHERC6, like hHERC5, cotranslationally modified nascent polypeptides. The ISGylome datasets presented here represent the largest numbers of protein targets and modification sites attributable to a single Ub/Ubl ligase and the lysine selectivities of the hHERC5 and mHERC6 enzymes may have implications for the activities of HECT domain ligases, generally.

Prospectively assessed summer mood status in major depression, recurrent with seasonal pattern: Evidence for SAD's construct validity.

OBJECTIVE: Seasonal patterns are often undetectable in population-based depression studies, calling into question the existence of winter seasonal affective disorder (SAD). If SAD has construct validity, individuals with SAD should show spontaneous depression remission in the summer. Data are sparse on prospectively assessed summer mood status in confirmed SAD patients. METHOD: We conducted prospective summer followup of community adults who, the winter before, were diagnosed with Major Depression, Recurrent with Seasonal Pattern on the Structured Clinical Interview for DSM-IV Axis I Disorders, developed a current SAD episode on the Structured Interview Guide for the Hamilton Rating Scale for Depression-Seasonal Affective Disorder Version (SIGH-SAD), and enrolled in a clinical trial comparing group cognitive-behavioral therapy for SAD and light therapy. In July/August after treatment, 143/153 (93.5 %) participants provided data on the SIGH-SAD, the Beck Depression Inventory-Second Edition, and the Longitudinal Interval Followup Evaluation (LIFE). RESULTS: Summer mean depression scores were in the normal range, with the substantial majority in remission across different measures. On the LIFE, 113/143 (79.0 %) experienced complete summer remission, 19/143 (13.3 %) experienced partial summer remission, and 11/143 (7.7 %) had major depression in the summer. Depression scores were significantly lower at summer than post-treatment in both treatments, indicating incomplete treatment response. LIMITATIONS: This was a single-site study with a relatively homogeneous sample. CONCLUSIONS: Supporting construct validity for SAD, the substantial majority experienced complete summer remission, with a minority in partial remission and a very small minority in episode. Both treatments left residual symptoms at treatment endpoint compared to summer.

Membrane-targeted mechanism for amphiphilic vitamin C compounds as methicillin-resistant Staphylococcus aureus biofilm eradicating agents.

Staphylococcus aureus infections and its biofilm removal is an important concern in health care management. Methicillin-resistant S. aureus is responsible for severe morbidity and mortality worldwide. The extensive use of disinfectants against biofilms has led to negative environmental impacts. Developing new and more potent biofilm eradication agents with minimal detrimental effects on human and environmental health is currently on the agenda. The alkyl esters of L-ascorbic acid (ASCn) are antioxidant amphiphiles, which show antimicrobial capacity against methicillin-sensitive and resistant S. aureus strains. ASC12 and ASC14 formulations are able to kill the persister cells of the deepest layers of the biofilm. We tested the hypothesis that the antimicrobial and antibiofilm capacity found for the ASCn emerges from a combined effect of its amphiphilic and their redox capacity. This mechanism appears related to: I) a larger diffusion capacity of the ASC12 micelles than ASC14 and ASC16 microstructures; II) the neutralization of the ASCn acid hydroxyl when the amphiphile reaches the surface of an anionic surface, followed by a rapid insertion; III) the disruption of cell membrane by alteration of membrane tension and structure and IV) ASCn accumulation in the cell membrane or biofilm extracellular matrix surfaces, reducing functional chemical groups and affecting its biological function.

Effectiveness of Omega-3 Fatty Acid Supplementation in Improving the Metabolic and Inflammatory Profiles of Mexican Adults Hospitalized with COVID-19.

BACKGROUND AND OBJECTIVES: The development of severe COVID-19 is related to the preexistence of comorbidities and an inadequate nutritional status. The latter is a critical factor for the development of infection and the progression of the disease. Notably, optimal nutrition impacts immune system function, as malnutrition is related to high cytokine levels in the late phase of the disease, correlating with a poor prognosis. In this sense, omega-3 fatty acids (O3FAs) have anti-inflammatory properties that may reduce morbidity and mortality from COVID-19 infection. O3FAs are linked to a better prognosis in COVID-19 patients. MATERIALS AND METHODS: In this randomized, double-blind clinical trial, we evaluate the administration of O3FAs to unvaccinated Mexican patients for two weeks starting after the first two hours of hospitalization. RESULTS: The findings support the notion that O3FAs (in a dose high enough to satisfy human physiological requirements in a short time, one capsule of 1.4 g O3FAs daily) exert a comprehensive multi-systemic modulatory influence, affecting inflammatory and metabolic pathways. Significant perturbations in biomarkers, including absolute neutrophil count, hematocrit, and platelet indices, underscore the compound's anti-inflammatory effect. Concurrently, the intervention modulates pivotal metabolic and hepatic parameters, attenuating cardiovascular risk profiles and expediting patient convalescence. These multifarious effects are likely orchestrated through intricate biochemical mechanisms and are subject to individual variations predicated on metabolic factors. CONCLUSIONS: The results of this trial support the notion that O3FA supplementation has beneficial effects on COVID-19 patients with moderate presentation by regulating metabolism and limiting inflammation.

Reconciliación y salud mental colectiva. La reincorporación de los excombatientes de las FARC-EP en Colombia, 2020 / Reconciliation and Collective Mental Health. The Reincorporation of FARC-EP Ex-combatants in Colombia, 2020

Resumen Un desafío en Colombia, a partir de la firma del Acuerdo de Paz con las FARC-EP, es retejer los vínculos rotos entre excombatientes y sociedad, aspiración presente en propuestas de desarme, desmovilización y reincorporación; reconciliación y salud mental. Desde una investigación cualitativa con excombatientes, familiares y vecinos, se presentan aspectos relacionados con el ingreso, permanencia y reincorporación y las contradicciones del retorno a la vida civil. Incumplimientos, incertidumbre, ausencia de un relato de corresponsabilidad, estigma y reaprendizaje de los códigos de la vida social, entre otros, son examinados desde los encuentros cotidianos con comunidades receptoras en contextos rurales.

Abstract A challenge in Colombia, since the signing of the Peace Agreement with the FARCEP, is to reweave the broken links between ex-combatants and society, an aspiration present in proposals for disarmament, demobilization, and reincorporation; reconciliation and mental health. From qualitative research with ex-combatants, family members, and neighbors, aspects related to the entry, permanence, and reincorporation, and the contradictions of the return to civilian life are presented. Non-compliance, uncertainty, absence of a narrative of co-responsibility, stigma, and re-learning of the codes of social life, among others, are examined from daily encounters with receiving communities in rural contexts.

Multicenter epidemiological study of maxillofacial trauma: a one-year retrospective- descriptive assessment of 1356 cases in a colombian metropolitan region / Estudio epidemiológico multicéntrico de trauma maxilofacial: evaluación retrospectiva-descriptiva de un año, de 1356 casos en una región metropolitana de Colombia

Background: This retrospective study was conducted to identify the epidemiological profile and treatment modalities linked to the maxillofacial trauma (MFT) managed in the Maxillofacial Surgery Departments of seven hospital centers in Antioquia, Colombia. Material and Methods: Clinical records with specific attention to sociodemographic characteristics, mechanisms of injury, type of MFT, location of injuries, and treatment modalities of MFT were collected from January to December 2017. Descriptive analyses using Pearson's chi-square tests were performed. Results: A total of 1356 records were retrieved. Males were significantly more affected, with a male-to-female ratio of 3.85:1. The most susceptible age group involved was young adults (18 to 40 years). A low percentage of alcohol (9.3%) and drugs consumption (2.5%) was recorded. Most common causes of MFT were road traffic accidents (RTA), falls, and interpersonal violence (IPV). Most injuries involved both soft and hard tissues followed by hard tissues and isolated open soft tissue injuries. Among fractures, the middle third was the most commonly affected site and the utmost method of treatment was open reduction and internal fixation. Conclusion: Within the limitations of the evidence available, this study has demonstrated that the gender, age stratum, and etiological factors, such as RTA, falls, and IPV, but no alcohol and/or psychoactive substances consumption, may have a significant influence on the prevalence, patterns, and treatment modalities of MFT in this sample population.

Antecedentes: Este estudio retrospectivo se realizó para identificar el perfil epidemiológico y las modalidades de tratamiento vinculados al Trauma Maxilofacial (TMF) atendido en los Servicios de Cirugía Maxilofacial de siete centros hospitalarios de Antioquia, Colombia. Material y Métodos: Se recopilaron historias clínicas con atención específica a las características sociodemográficas, mecanismos de lesión, tipo de TMF, ubicación de las lesiones y modalidades de tratamiento de TMF de enero a diciembre de 2017. Análisis descriptivos utilizando el chi-cuadrado de Pearson fueron realizados. Resultados: Se recuperaron un total de 1356 registros. Los hombres se vieron significativamente más afectados, con una relación hombre-mujer de 3,85:1. El grupo de edad más susceptible involucrado fue el de los adultos jóvenes (18 a 40 años). Se registró un bajo porcentaje de consumo de alcohol (9,3%) y drogas (2,5%). Las causas más comunes de TMF fueron los accidentes de tránsito (ADT), las caídas y la violencia interpersonal (VIP). La mayoría de las lesiones involucraron tejidos blandos y duros, seguidas de tejidos duros y lesiones abiertas aisladas de tejidos blandos. Entre las fracturas, el tercio medio fue el sitio afectado con mayor frecuencia y el método de tratamiento más utilizado fue la reducción abierta y la fijación interna. Conclusion: Dentro de las limitaciones de la evidencia disponible, este estudio ha demostrado que el género, el estrato etario y los factores etiológicos, como ADT, caídas y VIP , pero no el consumo de alcohol y/o sustancias psicoactivas, pueden tener una influencia significativa en la la prevalencia, los patrones y las modalidades de tratamiento de TMF en esta poblaión muestral.

Estigmatización social en el ámbito escolar generada por un diagnóstico psicológico / Social stigmatization in the school field generated by a psychological diagnosis

La presente investigación surge de la pregunta por la estigmatización social en el ámbito escolar, generada por un diagnóstico psicológico. El contexto educativo es escenario de diversas dinámicas que influyen en el proceso de desarrollo de los estudiantes, allí se viven etapas de transición como el paso de primaria a bachillerato, en un período de la vida en el cual el adolescente está en plena construcción de su identidad. Es una etapa de adaptación al entorno, siendo éste un período de vulnerabilidad que puede ser afectado significativamente cuando además, el estudiante lleva consigo un diagnóstico psicológico que puede generar estigmatización social. Esta investigación se llevó a cabo a partir de un rastreo teórico y un estudio de caso único, en el cual se le realizó una entrevista a un estudiante con un diagnóstico psicológico establecido, otra a su madre, una a un docente y finalmente a dos psicólogos de la institución educativa. Se lograron identificar las categorías de diagnóstico, sujeto escolar e identidad en relación a la estigmatización; y a partir de un trabajo riguroso de rastreo y análisis, se concluyó que tener un diagnóstico psicológico sí está altamente relacionado con la estigmatización social y la rotulación por parte de otras personas, lo cual tiene implicaciones importantes en el desarrollo psicosocial de la persona estigmatizada, generando repercusiones negativas como baja autoestima, inseguridad, depresión, aislamiento, agresividad, estrés, temor social, timidez, sensación de incapacidad, entre otras afectaciones que pueden surgir a partir de procesos de estigmatización.

This research arises from the question of social stigmatization in the school field generated by a psychological diagnosis. The educational context is the scene of various dynamics that influence the process of student development, there are stages of transition such as the transition from elementary to high school, in a period of life in which the adolescent is in full construction of his identity. It is a stage of adaptation to the environment, this being a period of vulnerability that can be significantly affected when the students also carries with them a psychological diagnosis that can generate social stigma. This research was conducted on the basis of a theoretical trace and a unique case study, in which an interview was conducted with a student with an established diagnosis, another to its mother, a teacher and two psychologists of the educational institution. It was possible to identify the categories of diagnosis, school subject and identity in relation to stigmatization, and from rigorous work of tracking and analysis, it was concluded that having a psychological diagnosis is highly related to social stigma and labeling by other people, which has important implications for the psychosocial development of the stigmatized person, generating negative repercussions such as low self-esteem, insecurity, depression, isolation, aggressiveness, stress, social fear, shyness, feeling incapacity, among other impacts that can arise from stigmatization processes.

Resultados visuales en pacientes operados de queratoplastia lamelar anterior profunda versus queratoplastia penetrante en el queratocono / Visual results in patients operated of deep anterior lamellar keratoplasty versus penetrating keratoplasty in keratoconus

RESUMEN Objetivo: Comparar los resultados visuales de la queratoplastia lamelar anterior profunda versus la queratoplastia penetrante en el tratamiento quirúrgico del queratocono. Métodos: Se realizó un estudio analítico longitudinal prospectivo en 81 pacientes con queratocono, operados de queratoplastia penetrante y queratoplastia lamelar anterior profunda entre los años 2014 y 2018. Se evaluó la edad, el sexo, la agudeza visual corregida, la esfera, el cilindro y el equivalente esférico. Resultados: La media de edad en operados de queratoplastia lamelar anterior profunda fue 27,5 ± 10,0 años, y 33,2 ± 12,9 años en operados de queratoplastia penetrante. En ambos grupos predominó el sexo masculino: 62,5 por ciento en el grupo de queratoplastia lamelar anterior profunda y 63,3 por ciento en el de queratoplastia penetrante. La agudeza visual corregida poscirugía en operados de queratoplastia lamelar anterior profunda fue 0,8 ± 0,19; el cilindro refractivo -3,50 ± 1,50; el equivalente esférico -6,07 ± 3,61, SimK1 de 46,37 ± 2,47 dioptrías y SimK2, 43,05 ± 2,47 dioptrías. En la queratoplastia penetrante, la agudeza visual corregida fue 0,68 ± 0,19; el cilindro refractivo -2,77 ± 0,98 dioptrías; el equivalente esférico -3,68 ± 1,56 dioptrías, SimK1 y SimK2 de 44,58 ± 2,77 dioptrías y 41,40 ± 2,93 dioptrías respectivamente. Conclusiones: Los resultados refractivos son similares en ambas técnicas quirúrgicas(AU)

ABSTRACT Objective: Compare the visual results of deep anterior lamellar keratoplasty versus penetrating keratoplasty in the surgical treatment of keratoconus. Methods: A longitudinal analytical prospective study was carried out in 81 patients with keratoconus, operated of penetrating keratoplasty and deep anterior lamellar keratoplasty between the years 2014 and 2018. The variables analyzed were the age, the sex, the corrected visual sharpness, the sphere, the cylinder and the spherical equivalent. Results: The average of age in operated patients of deep anterior lamellar keratoplasty was 27,5 ± 10,0 years, and 33,2 ± 12,9 years in operated of penetrating keratoplasty. In both groups the masculine sex predominated: 62,5 percent in the group of deep anterior lamellar keratoplasty and 63,3 percent in penetrating keratoplasty. The corrected visual sharpness in operated of queratoplastia lamelar previous deep was 0,8 ± 0,19; the refractive cylinder -3,50 ± 1,50; the spherical equivalent -6,07 ± 3,61, SimK1 of 46,37 ± 2,47 dioptres and SimK2, 43,05 ± 2,47 dioptres. In the penetrating keratoplasty, the corrected visual sharpness was 0,68 ± 0,19; the refractive cylinder -2,77 ± 0,98 dioptres; the spherical equivalent -3,68 ± 1,56 dioptres, SimK1 and SimK2 of 44,58 ± 2,77 dioptres and 41,40 ± 2,93 dioptres respectively. Conclusions: The refractive results are similar in both surgical technicians(AU)

Pain intensity and immediate puerperal discomforts / Intensidade de dor e desconfortos puerperais imediatos

ABSTRACT BACKGROUND AND OBJECTIVES: The immediate puerperium extends until the 10th day after delivery, and this period is characterized by the return of the woman's body to the pre-pregnancy state. The aims of the study were to identify pain intensity and the major discomforts reported by women in the immediate puerperium period and to analyze the difference in puerperal discomfort according to parity and type of delivery. METHODS: The participants included 107 women attended in a public maternity ward. Pain and discomfort were assessed using the semi-structured physical therapy assessment form and pain intensity was measured using the visual analog scale (VAS). Mann-Whitney and Kruskal-Wallis tests were applied to identify differences in discomfort according to the type of parity and delivery. RESULTS: Colic pain related to breastfeeding with 4.81±2.52 intensity was reported by 55.14% of mothers in the puerperium, perineal pain with 4,06±2,09 intensity by 30.84%, low back pain with 4.38±2.09 intensity by 28.97%, breast pain with 4.76±2.63 intensity by 23.36% and cesarean related pain with 5.21±2.01 intensity was reported by 17.75% of mothers. No significant differences in pain intensity were found according to parity. However, significant differences were found for perineal pain intensity and cesarean section. CONCLUSION: Pain intensity evaluated by the visual analog scale was classified as moderate or light.

RESUMO JUSTIFICATIVA E OBJETIVOS: O puerpério imediato estende-se até o 10º dia após o parto, e este período é caracterizado pelo retorno do corpo da mulher ao estado pré-gravídico. Os objetivos deste estudo foram identificar a intensidade da dor e principais desconfortos relatados pelas mulheres no puerpério imediato e analisar a diferença dos desconfortos puerperais de acordo com a paridade e tipo de parto. MÉTODOS: Participaram deste estudo 107 puérperas assistidas em uma maternidade pública. A dor e os desconfortos foram avaliados por meio da ficha de avaliação fisioterapêutica semiestruturada, e a intensidade da dor foi mensurada com a escala analógica visual. Os testes de Mann-Whitney e Kruskal-Wallis foram aplicados para identificar diferenças no desconforto a partir do tipo de parto e paridade. RESULTADOS: Dor em cólica relacionada à amamentação de intensidade 4,81±2,52 foi referida por 55,14% das puérperas, dor perineal de intensidade 4,06±2,09 foi referida por 30,84%, lombalgia de intensidade 4,38±2,09 foi referida por 28,97%, dor nas mamas de intensidade 4,76±2,63 foi referida por 23,36% e dor relacionada a cesariana de intensidade 5,21±2,01 por 17,75%. Não foram encontradas diferenças significativas na intensidade da dor de acordo com a paridade. No entanto, foram encontradas diferenças significativas para intensidade da dor perineal e incisão da cesariana. CONCLUSÃO: A intensidade da dor avaliada pela escala analógica visual foi classificada como moderada ou leve.

Quiste dermoide verdadero en piso de boca / True dermoid cyst in the floor of the mouth

Los quistes dermoides son lesiones benignas de origen embrionario, con una incidencia del 0,01 por ciento de todos los quistes de la cavidad bucal. No presenta predicción por sexo y alrededor del 60 por ciento de los casos se desarrollan entre los 15 y 35 años de edad. El conocimiento de los hallazgos clínicos de este tipo lesiones es vital para un diagnóstico definitivo, sin embargo, este siempre debe ser corroborado mediante exámenes histopatológicos, especialmente, al realizar un diagnóstico diferencial entre los diferentes tipos de quiste dermoides u otras alteraciones a nivel oral con manifestaciones clínicas similares. El propósito de esta presentación reportar un caso clínico para ampliar conocimientos sobre el diagnóstico y tratamiento de este tipo de lesión debido a su infrecuencia en cavidad oral. La ubicación inusual de estos quistes en cavidad oral hace que, aún con una buena valoración clínica e imaginológica, el diagnóstico prequirúrgico preciso sea difícil. Es por esto que el tratamiento quirúrgico no sólo evita el riesgo de una complicación infecciosa y eventual malignización sino que permite obtener un diagnóstico definitivo mediante estudios histopatológicos(AU)

Dermoid cysts are benign lesions of embryonic origin, with an incidence of 0.01 percent of all cysts in the oral cavity. There is no prediction by sex and about 60 percent of cases develop at the age of 15 to 35 years old. Knowledge of the clinical findings of such injuries is vital for a definitive diagnosis; however, this should always be confirmed by histopathological examination, especially when making a differential diagnosis between different types of dermoid cyst or other pathologies with similar clinical manifestations. The purpose of this article is to expand knowledge about the diagnosis and treatment of this type of injury because of it is not frequent in the oral cavity. The unusual location of these cysts in the oral cavity makes hard the precise preoperative diagnosis, even with good clinical and radio-graphical assessment. The surgical treatment not only prevents the risk of infectious complications and possible malignancy but also, allows obtaining a definitive diagnosis by a histopathological study(AU)

Análisis de las causa de reintervención en el pie equinovaro congénito / Analysis of the causes of reintervention in congenital equinovarus talipes

El objetivo de la cirugía del pie equinovaro congénito es obtener una adecuada y permanente corrección del defecto en un solo tiempo quirúrgico mediante la liberación de los componentes de la deformidad y la restauración anatómica del retro y medio pie, para así lograr un desarrollo normal de las articulaciones. En este trabajo analizamos 86 pies de 65 pacientes tratados quirúrgicamente, de los cuales 29 requirieron reintervención por persistir diversos componentes de la deformidad; de éstas, la más común fue el aducto de antepié seguido del varo y posteriormente el equino. La causa más frecuente de reintervención fue una insuficiente liberación con la que se obtuvo una corrección incompleta, así como falla en la valoración radiográfica transoperatoria