Detalhe da pesquisa
1.
Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry.
PLoS Pathog;
17(2): e1009312, 2021 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33539432
2.
DNA Targeting as a Likely Mechanism Underlying the Antibacterial Activity of Synthetic Bis-Indole Antibiotics.
Antimicrob Agents Chemother;
60(12): 7067-7076, 2016 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27620482
3.
New small molecule entry inhibitors targeting hemagglutinin-mediated influenza a virus fusion.
J Virol;
88(3): 1447-60, 2014 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24198411
4.
Synthesis and antifungal evaluation of head-to-head and head-to-tail bisamidine compounds.
Bioorg Med Chem;
23(17): 5789-98, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26209266
5.
Synthesis and structure-activity relationships of novel phenoxyacetamide inhibitors of the Pseudomonas aeruginosa type III secretion system (T3SS).
Bioorg Med Chem;
23(5): 1027-43, 2015 Mar 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25638499
6.
Structure-activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors.
Bioorg Med Chem;
23(9): 2024-34, 2015 May 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25818767
7.
Characterization of a novel pyranopyridine inhibitor of the AcrAB efflux pump of Escherichia coli.
Antimicrob Agents Chemother;
58(2): 722-33, 2014.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24247144
8.
Human cytomegalovirus UL97 kinase is involved in the mechanism of action of methylenecyclopropane analogs with 6-ether and -thioether substitutions.
Antimicrob Agents Chemother;
58(1): 274-8, 2014.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24145545
9.
Mutations in the Pseudomonas aeruginosa needle protein gene pscF confer resistance to phenoxyacetamide inhibitors of the type III secretion system.
Antimicrob Agents Chemother;
58(4): 2211-20, 2014.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24468789
10.
Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.
Bioorg Med Chem Lett;
24(15): 3366-72, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24969013
11.
Small molecule inhibitors of anthrax lethal factor toxin.
Bioorg Med Chem;
22(1): 419-34, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24290062
12.
Diels-Alder reactions of five-membered heterocycles containing one heteroatom.
Tetrahedron Lett;
55(51): 7002-7006, 2014 Dec 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25838605
13.
Human herpesvirus 6 U69 kinase phosphorylates the methylenecyclopropane nucleosides cyclopropavir, MBX 2168, and MBX 1616 to their monophosphates.
Antimicrob Agents Chemother;
57(11): 5760-2, 2013 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23979753
14.
Synthesis and antiviral activities of methylenecyclopropane analogs with 6-alkoxy and 6-alkylthio substitutions that exhibit broad-spectrum antiviral activity against human herpesviruses.
Antimicrob Agents Chemother;
57(8): 3518-27, 2013 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23669381
15.
Optimization of a novel potent and selective bacterial DNA helicase inhibitor scaffold from a high throughput screening hit.
Bioorg Med Chem Lett;
23(12): 3481-6, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23664213
16.
Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090.
Bioorg Med Chem;
21(24): 7790-806, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24239389
17.
Solute restriction reveals an essential role for clag3-associated channels in malaria parasite nutrient acquisition.
Mol Pharmacol;
82(6): 1104-14, 2012 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22949525
18.
Identification of a small-molecule entry inhibitor for filoviruses.
J Virol;
85(7): 3106-19, 2011 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21270170
19.
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.
Bioorg Med Chem;
20(12): 3710-8, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22607883
20.
Synthesis, Optimization, and Structure-Activity Relationships of Imidazo[1,2-a]pyrimidines as Inhibitors of Group 2 Influenza A Viruses.
J Med Chem;
65(20): 14104-14120, 2022 10 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36260129