Detalhe da pesquisa
1.
Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor.
Nature;
518(7538): 240-4, 2015 Feb 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25409150
2.
MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study.
Lancet Oncol;
14(3): 249-56, 2013 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23414587
3.
DJ-1, a novel regulator of the tumor suppressor PTEN.
Cancer Cell;
7(3): 263-73, 2005 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15766664
4.
Optimizing the Therapeutic Window of Targeted Drugs in Oncology: Potency-Guided First-in-Human Studies.
Clin Transl Sci;
14(2): 536-543, 2021 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33048459
5.
Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma.
Eur J Haematol;
80(6): 490-4, 2008 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18331598
6.
Preclinical Therapeutic Synergy of MEK1/2 and CDK4/6 Inhibition in Neuroblastoma.
Clin Cancer Res;
23(7): 1785-1796, 2017 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27729458
7.
Expression of epithelial cellular adhesion molecule (Ep-CAM) in chronic (necro-)inflammatory liver diseases and hepatocellular carcinoma.
Hepatol Res;
34(1): 50-6, 2006 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16364680
8.
Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies.
Clin Cancer Res;
22(7): 1592-602, 2016 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26673799
9.
A phase Ib dose-escalation study of the oral pan-PI3K inhibitor buparlisib (BKM120) in combination with the oral MEK1/2 inhibitor trametinib (GSK1120212) in patients with selected advanced solid tumors.
Clin Cancer Res;
21(4): 730-8, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25500057
10.
Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors.
Cancer Discov;
5(8): 850-9, 2015 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25971938
11.
Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.
J Clin Oncol;
30(3): 282-90, 2012 Jan 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22162589
12.
Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila.
Proc Natl Acad Sci U S A;
99(17): 11305-10, 2002 Aug 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12172011
13.
Selected bioethical issues in Japanese and German textbooks of biology for lower secondary schools.
J Moral Educ;
26(4): 473-89, 1997 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11656903