RESUMO
Tuberculosis is a fairly common disease in the United States and around the world, newly infecting ten million people throughout the world per year. Despite the pervasiveness of tuberculosis, cutaneous tuberculosis (CTB) rarely manifests worldwide. Tuberculous infections of the skin arise in several distinct variants that can be classified as either multibacillary or paucibacillary; each subtype within these categories presents with its own morphological and histological findings. The diagnosis of CTB can prove clinically challenging as its variants mimic many conditions dermatologist encounter on a daily basis. Additionally, tissue confirmation is difficult. We report a case of CTB which evolved from a lupus vulgaris presentation to the metastatic tuberculous abscess variant.
Assuntos
Pele/patologia , Tuberculose Cutânea/diagnóstico , Idoso , Biópsia , Diagnóstico Diferencial , Progressão da Doença , Feminino , Humanos , Lúpus Vulgar/complicações , Linfoma não Hodgkin/complicações , Mycobacterium/isolamento & purificação , Tuberculose Cutânea/diagnóstico por imagem , Tuberculose Cutânea/patologiaRESUMO
Non-Langerhans cell histiocytosis (NLCH) is a histiocyte disorder comprised of dermal dendritic histiocytes with a characteristic staining pattern. Erdheim-Chester disease (ECD) is a subset of NLCH in which patients experience bone pain with corresponding changes on imaging. In addition, these patients show other evidence of systemic involvement, which can also be identified with imaging. This disease can occasionally present with cutaneous findings. We present a case of generalized eruptive histiocytosis (GEH), misdiagnosed as ECD, found to have an NTRK1 gene rearrangement. This is the first report of an NTRK1 kinase fusion with NLCH. The implication is unclear and further studies are warranted.
Assuntos
Histiocitose de Células não Langerhans/diagnóstico , Lamina Tipo A/genética , Receptor trkA/genética , Adulto , Dorso , Fusão Gênica/genética , Histiocitose de Células não Langerhans/genética , Histiocitose de Células não Langerhans/patologia , Humanos , MasculinoAssuntos
Crioterapia , Lipectomia/métodos , Gordura Subcutânea Abdominal/cirurgia , Testosterona/sangue , Adulto , Humanos , MasculinoRESUMO
Mycosis fungoides (MF) is a rare cutaneous T-cell lymphoma (CTCL) which can cause significant morbidity. During the disease course, it classically will progress through three clinical stages in the skin: patch-, plaque-, and tumor-stage. The early stages exhibit various histopathological mimics that often lead to misdiagnosis. It rarely affects the oral cavity. Oral MF is historically associated with poor prognosis. We present a rare case of MF afflicting the dorsal tongue and extremities of a 72-year-old male.