Assuntos
Anormalidades Múltiplas/genética , Aberrações Cromossômicas , Transtornos Cromossômicos , Cromossomos Humanos 13-15 , Cromossomos Humanos 16-18 , Cromossomos Humanos 21-22 e Y , Cromossomos Humanos 4-5 , Cromossomos Humanos 6-12 e X , Anormalidades Múltiplas/diagnóstico por imagem , Adolescente , Adulto , Criança , Pré-Escolar , Síndrome de Cri-du-Chat , Síndrome de Down , Feminino , Humanos , Lactente , Recém-Nascido , Síndrome de Klinefelter , Deformidades Congênitas dos Membros , Masculino , Ossos Pélvicos/anormalidades , Radiografia , Aberrações dos Cromossomos Sexuais , Crânio/anormalidades , Coluna Vertebral/anormalidades , Tórax/anormalidades , Trissomia , Síndrome de TurnerAssuntos
Arteriosclerose Obliterante , Circulação Colateral , Artéria Femoral , Angiografia , HumanosRESUMO
Insulin binding on circulating red cells has been studied in hypertriglyceridemic (HTG) patients before and after normalization of plasma TG levels by a low fat and low CHO diet, followed for 2 months. Under basal condition HTG patients showed lower insulin binding on red cells (B/T) than control subjects. The reduction in binding was due to a lower receptor number (binding capacity). After the diet and normalization of TG levels, insulin binding was identical in HTG patients and always lower than in controls. The fasting values of blood glucose, IRI, FFA, were also unchanged after TG reduction, suggesting, together with the low insulin binding, a state of insulin resistance. We conclude that our lean patients, affected by HTG, present a state of insulin resistance. Despite normalization of plasma TG, obtained with diet alone, insulin receptor binding on red cells in unchanged.
Assuntos
Carboidratos da Dieta/administração & dosagem , Gorduras na Dieta/administração & dosagem , Eritrócitos/metabolismo , Hiperlipidemias/sangue , Receptor de Insulina/sangue , Triglicerídeos/sangue , Colesterol/sangue , HDL-Colesterol/sangue , Ácidos Graxos não Esterificados/sangue , Humanos , Hiperlipidemias/dietoterapia , Insulina/sangue , Resistência à Insulina , MasculinoRESUMO
Serum lipoproteins were studied in active and sedentary young women. The groups were matched for age, body weight, and blood pressure. A quantitative and qualitative evaluation of the diet was performed. In spite of a higher intake of saturated fat and cholesterol, serum concentrations of triglyceride, total cholesterol, and low-density lipoprotein cholesterol in the active group were not significantly different from the controls. Nevertheless, high-density lipoprotein cholesterol (HDL-C) levels were significantly higher in the active subjects even after covariance adjustment for nutrient intake; therefore, the HDL-C increase seems to depend on physical activity "per se" rather than on differences in diet.