Detalhe da pesquisa
1.
The mitochondrion of Plasmodium falciparum is required for cellular acetyl-CoA metabolism and protein acetylation.
Proc Natl Acad Sci U S A;
120(17): e2210929120, 2023 04 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37068227
2.
Dephospho-CoA kinase, a nuclear-encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption.
EMBO J;
40(16): e107247, 2021 08 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34031901
3.
Metabolic changes accompanying the loss of fumarate hydratase and malate-quinone oxidoreductase in the asexual blood stage of Plasmodium falciparum.
J Biol Chem;
298(5): 101897, 2022 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35398098
4.
Metabolic responses in blood-stage malaria parasites associated with increased and decreased sensitivity to PfATP4 inhibitors.
Malar J;
22(1): 56, 2023 Feb 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36788578
5.
A Chemical Proteomic Strategy Reveals Inhibitors of Lipoate Salvage in Bacteria and Parasites.
Angew Chem Int Ed Engl;
62(31): e202304533, 2023 08 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37249408
6.
Screening the Pathogen Box for Inhibition of Plasmodium falciparum Sporozoite Motility Reveals a Critical Role for Kinases in Transmission Stages.
Antimicrob Agents Chemother;
66(9): e0041822, 2022 09 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35943271
7.
A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites.
PLoS Pathog;
16(2): e1008316, 2020 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32059044
8.
Development of a conditional localization approach to control apicoplast protein trafficking in malaria parasites.
Traffic;
20(8): 571-582, 2019 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31094037
9.
Metabolic Survival Adaptations of Plasmodium falciparum Exposed to Sublethal Doses of Fosmidomycin.
Antimicrob Agents Chemother;
65(4)2021 03 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33495219
10.
Inter-study and time-dependent variability of metabolite abundance in cultured red blood cells.
Malar J;
20(1): 299, 2021 Jul 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34215262
11.
Host biotin is required for liver stage development in malaria parasites.
Proc Natl Acad Sci U S A;
115(11): E2604-E2613, 2018 03 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29483266
12.
Metabolic alterations in the erythrocyte during blood-stage development of the malaria parasite.
Malar J;
19(1): 94, 2020 Feb 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32103749
13.
Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability.
Malar J;
18(1): 86, 2019 Mar 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30890151
14.
A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species.
Mol Microbiol;
106(3): 439-451, 2017 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28836704
15.
Crystal structure of lipoate-bound lipoate ligase 1, LipL1, from Plasmodium falciparum.
Proteins;
85(9): 1777-1783, 2017 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28543853
16.
Redox-dependent lipoylation of mitochondrial proteins in Plasmodium falciparum.
Mol Microbiol;
94(1): 156-71, 2014 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25116855
17.
The suf iron-sulfur cluster synthesis pathway is required for apicoplast maintenance in malaria parasites.
PLoS Pathog;
9(9): e1003655, 2013.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24086138
18.
A key role for lipoic acid synthesis during Plasmodium liver stage development.
Cell Microbiol;
15(9): 1585-604, 2013 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23490300
19.
The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target.
Bioorg Med Chem Lett;
24(3): 911-6, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24398298
20.
Progressive heterogeneity of enlarged and irregularly shaped apicoplasts in P. falciparum persister blood stages after drug treatment.
bioRxiv;
2024 Jan 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38410435