Detalhe da pesquisa
1.
Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis.
Cell;
173(1): 260-274.e25, 2018 03 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29551266
2.
Bromodomain proteins regulate human cytomegalovirus latency and reactivation allowing epigenetic therapeutic intervention.
Proc Natl Acad Sci U S A;
118(9)2021 03 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33619107
3.
The Epigenetic Reader Protein SP140 Regulates Dendritic Cell Activation, Maturation and Tolerogenic Potential.
Curr Issues Mol Biol;
45(5): 4228-4245, 2023 May 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37232738
4.
In silico enhancer mining reveals SNS-032 and EHMT2 inhibitors as therapeutic candidates in high-grade serous ovarian cancer.
Br J Cancer;
129(1): 163-174, 2023 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37120667
5.
Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling.
Nat Immunol;
12(1): 29-36, 2011 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21131967
6.
Epigenetic Regulation of T Cell Memory: Recalling Therapeutic Implications.
Trends Immunol;
41(1): 29-45, 2020 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31813765
7.
IFN-γ Drives Human Monocyte Differentiation into Highly Proinflammatory Macrophages That Resemble a Phenotype Relevant to Psoriasis.
J Immunol;
207(2): 555-568, 2021 07 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34233910
8.
Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism.
Proc Natl Acad Sci U S A;
117(11): 6056-6066, 2020 03 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32123118
9.
Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140.
BMC Biol;
20(1): 182, 2022 08 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35986286
10.
Selective inhibitors of bromodomain BD1 and BD2 of BET proteins modulate radiation-induced profibrotic fibroblast responses.
Int J Cancer;
151(2): 275-286, 2022 07 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35239184
11.
Phase 1 and preclinical profiling of ESM-HDAC391, a myeloid-targeted histone deacetylase inhibitor, shows enhanced pharmacology and monocytopaenia.
Br J Clin Pharmacol;
88(12): 5238-5256, 2022 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35655123
12.
BET inhibitor resistance emerges from leukaemia stem cells.
Nature;
525(7570): 538-42, 2015 Sep 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26367796
13.
Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.
Mol Cell;
51(3): 310-25, 2013 Aug 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23932714
14.
Bromodomain inhibitor I-BET151 suppresses immune responses during fungal-immune interaction.
Eur J Immunol;
49(11): 2044-2050, 2019 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31206650
15.
Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells.
J Biol Chem;
293(7): 2422-2437, 2018 02 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29301935
16.
Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome.
PLoS Biol;
13(12): e1002316, 2015 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26646171
17.
Suppression of the antiviral response by an influenza histone mimic.
Nature;
483(7390): 428-33, 2012 Mar 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22419161
18.
Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells.
Proc Natl Acad Sci U S A;
112(32): E4448-57, 2015 Aug 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26216992
19.
Inhibition of BET Proteins Reduces Right Ventricle Hypertrophy and Pulmonary Hypertension Resulting from Combined Hypoxia and Pulmonary Inflammation.
Int J Mol Sci;
19(8)2018 Jul 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30061518
20.
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Nat Chem Biol;
11(3): 189-91, 2015 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25622091