Development of active packaging films based on liquefied shrimp shell chitin and polyvinyl alcohol containing ß-cyclodextrin/cinnamaldehyde inclusion.

To maintain the freshness of fruits and to meet environmental and consumer needs, a biobased packaging film with long-lasting antimicrobial activity was developed in this article. Liquefied ball-milled shrimp shell chitin/polyvinyl alcohol (LBSC/PVA) blend films containing varying concentrations (0, 1, 2, 3, 4, 5 wt%) of the ß-cyclodextrin/cinnamaldehyde (ß-CD/CA) inclusion were prepared and characterized. The association between ß-CD and CA and the sustained release behavior of CA were explored. The physicochemical property, antimicrobial activity and food preservation performance of the films were investigated. Results showed that CA was successfully encapsulated into the cavity of CD by host-guest interactions, which greatly improved the sustained release of CA. The 3 wt% ß-CD/CA/LBSC/PVA blend film showed optimized mechanical properties with a tensile strength of 41.5 MPa and an elongation at break of 810 %. In addition, the incorporation of ß-CD/CA inclusion significantly enhanced the antimicrobial activity and food preservation performance of the blend films. Moreover, the 3 wt% ß-CD/CA/LBSC/PVA blend film exhibited evidently longer lasting antimicrobial activity and cherry tomato preservation performance than the 3 wt% CA/LBSC/PVA blend film, further demonstrating the critical role of ß-CD in delaying CA release. These novel ß-CD/CA/LBSC/PVA blend films may have a potential use in active food packaging.

Effect of sodium lauryl sulfate-mediated gelation on the suppressed dissolution of crystalline lurasidone hydrochloride and a strategy to mitigate the gelation.

In dissolution test, the surfactant sodium lauryl sulfate (SLS) is usually added to increase the dissolution of insoluble drugs and achieve the sink condition. However, the current study found that 0.1 % SLS would significantly decrease the dissolution of crystalline lurasidone hydrochloride (LH, a BCS Ⅱ drug). The aim of this study was to clarify the mechanism of this unexpected phenomenon and explore a strategy for mitigating the negative effect of SLS on the dissolution of LH. Sample characterizations (such as PLM, DSC, PXRD, IR and NMR) confirmed that the insoluble single-phase amorphous LH-SLS complex (with a single Tg at 35.2 °C) formed during dissolution in 0.1 % SLS aqueous solution via electrostatic interaction, tetrel bond interaction, and hydrophobic effect. Due to the plasticization effect of water, the transition of amorphous LH-SLS from its glassy state to viscous supercooled liquid state led to the gel formation, and suppressd the dissolution of LH. Meanwhile, the solubility curve of LH in SLS aqueous solution at various concentrations exhibited an unusual V-shaped feature, with the CMC value of SLS serving as the inflection point, since the gel degree was attenuated due to the micelle solubilization of SLS. Additionally, an innovative strategy was developed to alleviate the inhibiting effect of SLS on LH dissolution based on the potential competitive interactions. This study not only enriches the internal mechanism of surfactant-inhibited drug dissolution but also informs an effective strategy to mitigate the gelation.