Detalhe da pesquisa
1.
Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase inhibitor.
Mol Pharmacol;
79(6): 910-20, 2011 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21372172
2.
JNJ-26070109 [(R)4-bromo-N-[1-(2,4-difluoro-phenyl)-ethyl]-2-(quinoxaline-5-sulfonylamino)-benzamide]: a novel, potent, and selective cholecystokinin 2 receptor antagonist with good oral bioavailability.
J Pharmacol Exp Ther;
338(1): 328-36, 2011 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21493750
3.
A one-step synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid esters from o-nitrobenzaldehydes.
J Org Chem;
75(10): 3488-91, 2010 May 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20420395
4.
Characterization of a robust enzymatic assay for inhibitors of 2-oxoglutarate-dependent hydroxylases.
J Biomol Screen;
14(6): 627-35, 2009 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19498081
5.
Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists I: discovery of CCKR1 selectivity in a previously CCKR2-selective lead series.
Bioorg Med Chem Lett;
19(22): 6373-5, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19811913
6.
Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists II: tuning of receptor selectivity and in vivo efficacy.
Bioorg Med Chem Lett;
19(22): 6376-8, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19815410
7.
Discovery of the first known small-molecule inhibitors of heme-regulated eukaryotic initiation factor 2alpha (HRI) kinase.
Bioorg Med Chem Lett;
19(23): 6548-51, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19854648
8.
Beyond Traditional Structure-Based Drug Design: The Role of Iron Complexation, Strain, and Water in the Binding of Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylase 2.
ACS Omega;
4(4): 6703-6708, 2019 Apr 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31179408
9.
Discovery of potent cholecystokinin-2 receptor antagonists: elucidation of key pharmacophore elements by X-ray crystallographic and NMR conformational analysis.
Bioorg Med Chem;
16(7): 3917-25, 2008 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18289861
10.
Synthesis and solid-phase purification of anthranilic sulfonamides as CCK-2 ligands.
Bioorg Med Chem Lett;
17(24): 6905-9, 2007 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18029172
11.
Identification and optimization of anthranilic sulfonamides as novel, selective cholecystokinin-2 receptor antagonists.
J Med Chem;
49(21): 6371-90, 2006 Oct 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17034143
12.
Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons.
Oncotarget;
7(37): 58876-58892, 2016 09 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27557499
13.
Substrate specificity and novel selective inhibitors of TNF-alpha converting enzyme (TACE) from two-dimensional substrate mapping.
Comb Chem High Throughput Screen;
8(4): 327-39, 2005 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16101009
14.
Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats.
Br J Pharmacol;
172(16): 4078-88, 2015 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25988595
15.
Physiological Control of Nitric Oxide in Neuronal BACE1 Translation by Heme-Regulated eIF2α Kinase HRI Induces Synaptogenesis.
Antioxid Redox Signal;
22(15): 1295-307, 2015 May 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25706765
16.
Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses.
J Med Chem;
56(23): 9369-402, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23977883
17.
Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues.
ACS Med Chem Lett;
1(9): 526-9, 2010 Dec 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24900242
18.
Hantzsch synthesis of pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridines: partial agonists of the calcitonin receptor.
J Org Chem;
70(13): 5331-4, 2005 Jun 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15960543